1,720,976 research outputs found
Opioid epidemic spread from northern and eastern europe to mediterranean area
No full textThe addiction to illicit opioid and the misuse of prescription synthetic opioids pain relievers and fentanyl analogs generated an opioid epidemic in North America over the last two decades that affected public health with a constantly rising number of overdoses deaths. This health treat moved to Europe with a significant increase starting from 2015 involving mainly norther and eastern countries and finally also the Mediterranean area. The "lock down" isolation and economic recession caused by COVID-19 pandemic showed a resurgence in opioid use and harms
Improvement of hair testing for Ethylglucuronide by supported liquid extraction and ultra-high performance liquid chromatography tandem mass spectrometry
No full textTo improve the reproducibility, suitability and speed of hair testing for Ethylglucuronide (EtG), an ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated together with a supported liquid extraction (SLE) EtG from the keratin matrix. EtG was analyzed using reversed phase chromatography with gradient elution and detection with tandem mass spectrometry operated in multiple reaction monitoring (MRM) mode via negative electrospray ionization (ESI). The method showed good linearity from limit of quantification (LOQ) to 100 pg/mg hair (r2 0.996 ± 0.004). Recovery of the analyte was always higher than 80%, whereas intra- and inter-assay precision were always better than 15%. The developed method was applied to the analysis of more than 200 samples with medico-legal and epidemiological purposes ranging from non-detection of the analyte to 88.1 pg/mg and its robustness was proved by reanalysis of six different proficiency testing samples from the Society of hair testing obtaining a Z-score always less than 2
The issue of psychotropic drug monitoring in sexual assault victims
No full textDrug-facilitated sexual assault (DFSA) is a sexual act in which the victim is unable to give or deny consent due unconsciousness caused by intoxication with alcohol and/or psychoactive drugs that have been self-administered (opportunistic DFSA) or surreptitiously administered by the offender (predatory DFSA). . The characteristics of drugs used in DFSA include: being tasteless and odourless and readily soluble in beverages of any type; ability to cause sedation and/or anterograde amnesia; rapidly absorbable after oral administration, and with a most possible rapid clearance from the body (e.g. within 24 h). In DFSA, the victim is unconscious, unable to reject the abuser and unable to clearly remember the circumstances surrounding the intercourse. The consequence is the delay in requiring and carrying out toxicological analysis on the biological matrices of the victim or even the reluctance of the victim to disclose the crime. Moreover, since the so-called “date rape drugs” are often consumed with ethanol and show similar toxicodynamic effects, the diagnosis can be wrongly considered as classical ethanol intoxication
Phenomenic aspects of the school maladjustment in preadolescence.
No full textThe Authors present the data relative to the administration of the Children's Depression Inventory (CDI - Italian version) and the Sociometic Questionnaire to a random sample of 52 preadolescent students (10-12.6 years old). Successively the students of the sample who showed a risk for affective and social disorders and a poor school achievement were evaluated with Rorschach test
Aspetti fenomenici del disadattamento scolastico nella preadolescenza.
No full textThe Authors present the data relative to the administration of the Children's Depression Inventory (CDI - Italian version) and the Sociometic Questionnaire to a random sample of 52 preadolescent students (10-12.6 years old). Successively the students of the sample who showed a risk for affective and social disorders and a poor school achievement were evaluated with Rorschach test
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Hair testing of propofol by liquid chromatography-tandem mass spectrometry and azo-coupling derivatization
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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