27,112 research outputs found
In situ analysis of pH gradients in mosquito larvae using non-invasive, self-referencing, pH-sensitive microelectrodes
No full textThe alkaline environment, pH approximately 11, in the anterior midgut lumen of mosquito larvae is essential for normal nutrition and development. The mechanism of alkalization is, however, unknown. Although evidence from immunohistochemistry, electron microscopy and electrophysiology suggests that a V-ATPase is present in the basal membranes of the epithelial cells, its physiological role in the alkalization process has not been demonstrated. To investigate a possible role of the V-ATPase in lumen alkalization, pH gradients emanating from the hemolymph side of the midgut in semi-intact mosquito larvae were measured using non-invasive, self-referencing, ion-selective microelectrodes (SERIS). Large H+ concentration gradients, with highest concentrations close to the basal membrane (outward [H+] gradients), were found in the anterior midgut, whereas much smaller gradients, with concentrations lowest close to this membrane (inward [H+] gradients), were found in the gastric caeca and posterior midgut. Similar region-specific pH gradients, with consistent anterior-to-posterior profiles, were observed in individuals of two Aedes species, Aedes aegypti from semi-tropical Florida and Aedes canadensis from north-temperate Massachusetts. The gradients remained in a steady state for up to 6 h, the maximum duration of the recordings. Bafilomycin A1 (10(-5), 10(-7 )mol x l(-1)) on the hemolymph side greatly diminished the [H+] gradients in the anterior midgut but had no effect on the gradients in the gastric caecum and posterior midgut. These physiological data are consistent with the previous findings noted above. Together, they support the hypothesis that a basal, electrogenic H+ V-ATPase energizes luminal alkalization in the anterior midgut of larval mosquitoes
Groundstate asymptotics for a class of singularly perturbed p-Laplacian problems in RN
No full textWe study the asymptotic behaviour of positive groundstate solutions to the quasilinear elliptic equation [Figure not available: see fulltext.]where 1 < p< N, p< q< l< + ∞ and ε> 0 is a small parameter. For ε→ 0 , we give a characterization of asymptotic regimes as a function of the parameters q, l and N. In particular, we show that the behaviour of the groundstates is sensitive to whether q is less than, equal to, or greater than the critical Sobolev exponent p∗:=pNN-p
New copper(II) 1D polymer containing dimethyl(phenylsulfonyl)amidophosphate: Synthesis, crystal structure and magnetic properties
No full textThe reaction of sodium dimethyl(phenylsulfonyl)amidophosphate NaL (HL=C(6)H(5)SO(2)NHP(O)(OCH(3))(2)) with Cu(NO(3))(2) center dot 6H(2)O and o-bpe (1,2-bis(pyridine-2-yl)ethane) in appropriate ratios, afford the formation of 1D coordination polymer [Cu(L)(2) center dot o-bpe](n) in good yield. The crystal structures of HL (1) and [Cu(L)(2) center dot o-bpe](n) (2) are reported. In the crystal package the molecules of 1 are linked by intermolecular hydrogen bonds formed by the phosphoryl oxygen atoms which serve as acceptors and nitrogen atoms of amide groups as donors. The crystal structure of 2 indicates the presence of unsaturated Cu(L)(2) unit bridged by o-bpe ligand in the one-dimensional polymeric chain. The Cu(II) atoms have distorted 4 + 2 octahedral CuO(4)N(2) environment formed by the oxygen atoms belonging to the sulfonyl and phosphoryl groups of two deprotonated chelate ligands and nitrogen atoms of the bridging o-bpe ligands. The magnetic study of 2 has revealed the presence of a weak intrachain antiferromagnetic exchange interaction between copper ions. (C) 2009 Elsevier Ltd. All rights reserved.Fundamental Researches State Fund of Ukraine [F25/193 - 2008
Sustained High-dose Thiamine Supplementation in High-risk Cardiac Patients Undergoing Cardiopulmonary Bypass: A Pilot Feasibility Study (The APPLY trial)
No full textObjective: To test the feasibility and investigate possible cardiovascular effects of a sustained high-dose intravenous thiamine protocol in patients undergoing combined valvular and coronary artery bypass graft surgery. Design: Randomized, placebo-controlled, pilot feasibility trial. Setting: Cardiac surgery department of a tertiary hospital. Participants: Forty patients undergoing combined valvular and coronary artery bypass surgery. Interventions: Intravenous thiamine (600 mg on the day of surgery, and 400 mg/day on postoperative days 1, 2, and 3) or placebo. Measurements and Main Results: The primary feasibility endpoints were recruitment rate and protocol compliance. Secondary endpoints included markers of possible biological and physiological effects. The mean recruitment rate was 8 patients per month and protocol compliance was 97.5%. There were no differences in median peak postoperative lactate (2.7 mmol/L [interquartile range [IQR] 1.4-4.6] for thiamine v 2.5 mmol/L [IQR 1.4-3.6] for placebo; p = 0.53), median peak postoperative creatinine (104 μmol/L [IQR 92.5-129] for thiamine v 99 μmol/L [IQR 86.5-109.5] for placebo; p = 0.53), median nadir postoperative cardiac index (1.8 L/min/m2 [IQR 1.5-2.1] for thiamine v 2.2 L/min/m2 [IQR 1.5-2.5] for placebo; p = 0.25), or the number of patients on vasopressor/inotropic agents (thiamine, 12 [63%]; placebo, 12 [60%]; p = 0.80), or in the total inotrope/vasopressor dose 0.14 μg/kg for thiamine v 0.12 μg/kg for placebo; p = 0.88). Conclusions: A double-blind trial of sustained high-dose intravenous thiamine supplementation in higher-risk cardiac surgery patients was feasible and appeared to be safe. However, such treatment did not demonstrate evidence of biological or physiological effects
Availability Assessment of a Cloud Server System: Comparing Markov and Semi-Markov Models
No full textO. Ivanchenko, V. Kharchenko, B. Moroz, Y. Ponochovnyi and L. Degtyareva, "Availability Assessment of a Cloud Server System: Comparing Markov and Semi-Markov Models," 2021 11th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications (IDAACS), 2021, pp. 1-6, doi: 10.1109/IDAACS53288.2021.9661052, , O. Ivanchenko, V. Kharchenko, B. Moroz, Y. Ponochovnyi, L. Degtyareva, "Availability Assessment of a Cloud Server System: Comparing Markov and Semi-Markov Models," 2021 11th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications (IDAACS), Crakow, Poland, 2021, pp. 1157-1162.Nowadays Markov Modelling Processes (MMP) found widely use into realm pertaining to availability assessments of diverse complex. technical systems and devices. In this regard, Cloud Server Systems (CSSs) are no exception. However, in order to leverage MMPs for the availability evaluation of CSSs the researchers should take into account that this assessmet procedure based on the utilization of just one distributio that is exponential distribution of times to failure, times 10
repair et prelit events and impacts. In that regard, that some groups of researchers into realm pertaining to CSSs availability are increasingly trying to leverage approaches based on Sem Markov Modelling Processes (SMMPs). Using SMMPs the researchers can consider more number of parametric characteristics and have a realistic picture as regards of availability level for the server system addition, seeking to improve overall availability of CSSs, the results for SMMPs in the so-called borders’ states, when Non-Markovian Process transforms at Markovian Process
Availability Assessment of a Cloud Server System: Comparing Markov and Semi-Markov Models
No full textO. Ivanchenko, V. Kharchenko, B. Moroz, Y. Ponochovnyi and L. Degtyareva, "Availability Assessment of a Cloud Server System: Comparing Markov and Semi-Markov Models," 2021 11th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications (IDAACS), 2021, pp. 1-6, doi: 10.1109/IDAACS53288.2021.9661052, , O. Ivanchenko, V. Kharchenko, B. Moroz, Y. Ponochovnyi, L. Degtyareva, "Availability Assessment of a Cloud Server System: Comparing Markov and Semi-Markov Models," 2021 11th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications (IDAACS), Crakow, Poland, 2021, pp. 1157-1162.Nowadays Markov Modelling Processes (MMP) found widely use into realm pertaining to availability assessments of diverse complex. technical systems and devices. In this regard, Cloud Server Systems (CSSs) are no exception. However, in order to leverage MMPs for the availability evaluation of CSSs the researchers should take into account that this assessmet procedure based on the utilization of just one distributio that is exponential distribution of times to failure, times 10
repair et prelit events and impacts. In that regard, that some groups of researchers into realm pertaining to CSSs availability are increasingly trying to leverage approaches based on Sem Markov Modelling Processes (SMMPs). Using SMMPs the researchers can consider more number of parametric characteristics and have a realistic picture as regards of availability level for the server system addition, seeking to improve overall availability of CSSs, the results for SMMPs in the so-called borders’ states, when Non-Markovian Process transforms at Markovian Process
Fig. 1 in Submicroscopic Changes In The Hepatopancreas Of Freshwater Mollusks Infected With Parthenites Of Trematodes Echinoparyphium Aconiatum (Echinostomida) And Plagiorchis Elegans (Plagiorchiida)
No full textFig. 1. Acinus of L. stagnalis hepatopancreas: A: Cells of L. stagnalis hepatopancreas acinus: 1 — hepatic cell; 2 — lime cell. (Electronogram ×4800); B: Hepatic and lime cells of a L. stagnalis hepatopancreas fragment undamaged by trematode parthenitis: 1 — hepatic cell; 2 — nucleus; 3 — heterochromatin; 4 — pore in the nuclear envelope; 5 — perinuclear space; 6 — the lumen of the acinus; 7 — lime cell; 8 — the nucleus of the lime cell. (Electronogram ×13000).Published as part of Zhytova, O., Kot, T., Huralska, S., Andreieva, O. & Moroz, V., 2021, Submicroscopic Changes In The Hepatopancreas Of Freshwater Mollusks Infected With Parthenites Of Trematodes Echinoparyphium Aconiatum (Echinostomida) And Plagiorchis Elegans (Plagiorchiida), pp. 431-438 in Zoodiversity 55 (5) on page 433, DOI: 10.15407/zoo2021.05.431, http://zenodo.org/record/645610
Spectral features of 21 Lutetia, target of Rosetta mission
No full textThe International Rosetta Mission, successfully
launched on March 2nd 2004, will encounter
comet 67P/Churyumov-
Gerasimenko, the principal target of the
mission, in 2014. During its long journey
Rosetta will fly-by also two asteroids: 2867
Steins (September 2008) at a distance of
about 1700 km and at a relatively low speed
of about 9 kilometers per second and 21 Lutetia
(July 2010) at about 3000 km at a speed
of 15 kilometers per second.
Rosetta will try to answer to the main questions
related to the origin and evolution of the
Solar System as minor bodies contains the
record of the chemical, physical and dynamical
primordial processes of the formation of
our planetary system.
In this work we present the analysis of two
visible spectra of Lutetia taken at NTT-ESO,
Chile, in order to confirm the presence of
absorption bands previously determined on
other spectra of the asteroid (Lazzarin et al.,
A&A, 2004).In particular, we investigated the spectral region
where these bands were detected by using
a higher spectral resolution. We confirm
a broad complex feature between 0.45
and 0.55 micron and two narrower features
around 0.47 and 0.52 micron which possible
origin will be discussed.
A more precise knowledge of the surface
composition of Lutetia is particularly
important for the definition of the observational
strategy of the Rosetta mission
Principles of Enterprise Potential Management in The Coordinates System of Organizational Development
No full textKniaz S., Sopilnyk L., Shchebel A, Moroz S., Kalashnyk O., Skrynkovskyy R., Kramar M., Spitsyna A., Gnylianska L., Lakiza V. (2020) Principles of Enterprise Potential Management in The Coordinates System of Organizational Development. Proceedings of the 36th Conference: November 2020, Granada, Spain, p 7192-7201
Principles of Enterprise Potential Management in The Coordinates System of Organizational Development
No full textKniaz S., Sopilnyk L., Shchebel A, Moroz S., Kalashnyk O., Skrynkovskyy R., Kramar M., Spitsyna A., Gnylianska L., Lakiza V. (2020) Principles of Enterprise Potential Management in The Coordinates System of Organizational Development. Proceedings of the 36th Conference: November 2020, Granada, Spain, p 7192-7201
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