3,386 research outputs found
Including Social Nash Equilibria in Abstract Economies
No full textWe consider quasi-variational problems (variational problems having constraint sets depending on their own solutions) which appear in concrete economic models such as social and economic networks, financial derivative models, transportation network congestion and traffic equilibrium. First, using an extension of the classical Minty lemma, we show that new upper stability results can be obtained for parametric quasi-variational and linearized quasi-variational problems, while lower stability, which plays a fundamental role in the investigation of hierarchical problems, cannot be achieved in general, even on very restrictive conditions. Then, regularized problems are considered allowing to introduce approximate solutions for the above problems and to investigate their lower and upper stability properties. We stress that the class of quasi-variational problems include social Nash equilibrium problems in abstract economies, so results about approximate Nash equilibria can be easily deduced.quasi-variational, social Nash equilibria, approximate solution, closed map, lower semicontinuous map, upper stability, lower stability
Patients entered into MRC AML trials are biologically representative of the totality of the disease in the UK
No full textDesign of a new Faculty of Architecture - Investigation and design of Media Facades
No full textGraduation Project [G.J. Smit] for both Architecture & Building Technology. [architecture] : design of a new Faculty of Architecture [building technology] : investigation and design of Media FacadesStrategic Architectural Design DevelopmentArchitecture & Building TechnologyArchitectur
Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemia
No full textIt is generally considered that most cancers arise following the accumulation of several genetic events and that as a consequence its incidence increases with age. We report a cytogenetic subgroup of acute myeloid leukaemia whose incidence is independent of age. This observation indicates that acute myeloid leukaemia can develop via multiple pathways, and underlines the importance of cytogenetics in understanding this disease
Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
No full textCytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies
Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities
No full textAcute myeloid leukaemia (AML) cases with different chromosomal abnormalities may reflect different aetiologies. Benzene exposure, from a number of sources including smoking, is one risk factor for AML. Individual susceptibility to benzene may depend on differences in expression of metabolizing enzymes. We tested the hypothesis that smoking as well as genetic polymorphisms in the microsomal epoxide hydrolase gene (HYL1), an enzyme involved in benzene metabolism, could be risk factors for AML with defined chromosomal abnormalities. Twenty-six AML cases with ?7/del(7q) and 24 cases with t(8;21), as well as 43 cases with normal karyotype and 155 age-, sex- and residence-matched controls, were drawn from a large case–control study on adult acute leukaemia. Current smoking was significantly associated with the cytogenetic abnormalities t(8;21) or ?7/del(7q) (OR = 4·9; 95%CI = 2·1–11·5) but not with a normal karyotype, relative to individuals who were not current smokers. A putative high activity HYL1 phenotype [exon 3, residue 113 (Tyr/Tyr) and exon 4, residue 139 (His/Arg or Arg/Arg)] was associated with a significantly increased AML risk in men with ?7/del(7q) or t(8;21) (OR = 4·4; 95%CI 1·1–17·0) but not with a normal karyotype. This suggests that AML cases with defined chromosomal abnormalities could be related to specific carcinogen exposures and, furthermore, suggests that smoking and genetic polymorphisms in HYL1 could be risk factors for AML with ?7/del(7q) or t(8;21)
Watertovenaars: Delftse ideeën voor nog 200 jaar Rijkswaterstaat
No full textEen bundel artikelen met inspiratie voor Rijkswaterstaat voor de ontwikkeling in de volgende 200 jaar. Watertovenaar of tovenaarsleerling? (K. d'Angremond, P. Huisman en G.I. Schiereek) De oudste deltawerken: dammen en duikers uit het begin van de jaartelling (T. de Ridder) Een erfenis uit de Bataafse periode (W.M. de Jong) Wat eerst: wonen, water, wegen of welvaart? (T.M. de Jong) Een nieuwe rol voor de waterstaatsingenieur (F.M. Sanders) De terugkeer van de stedenbouwkundige discipline (V.J. Meyer Water (P. Huisman, K. d'Angremond en G.J. Schiereek) Dynamische buffers in autosnelwegen (D. Westland en P.H.L. Bovy) Op de automatische piloot door de Randstad? (R. van der Heijden, V. Marchau, E. Molin en K. van Wees) Niet bruggen bouwen, maar zelf brug zijn (B. Enserink, M.P.M. van der Ploeg, WAH. Thissen en G.J. de Vreede) Nederland als vervoersemplacement? (M.P.C. Weijnen, W.A.H. Thissen en E.F. ten Heuvelhof) Immobilisatie van gevaarlijk afval (Ch.F.Hendriks) Dubbel verduurzamen van wegconstructies (A.A.A. Molenaar) Innovatie van de geometrische infrastructuur (P.J.G.Teunissen) Radarhoogtemetingen en de (voorname) rol van Delft (M. Naeije) Een hoog(water)standje (T. Rientjes, C. van den Akker en P. van der Veer) Naar één beslismodel voor de veiligheid (J.K. Vrijling en J. Stoop) De betrouwbaarheid van dijken (A. Verruijt) Windgolven, een fascinerend fenomeen (L.H. Holthuijsen en J.A. Battjes) Mijn droom: het railvaartuig (B. Boon) Een waterfilm in plaats van wielen (A. van Beek) Uren worden minuten (E.A.H. Vollebregt, H. Jansen en M.R.T. Roest) Een kwestie van schuiven (R.Brouwer, A.Hof en J. Schuurmans) Energie door vergisting van slib (M.S.M. letten en M.C.M. van Loosdrecht) Nóg een poldermodel: hoge-sterkte beton (J.C. Walraven) Atollen voor de Noordzeekust (J. Kristinsson) Van maker naar regisseur (H.A.J. de Ridder
Mountell (Birth, 1884-10-26)
No full textAddress: Concord & Morgan - Walnut Hills2974/Pg. 77/1884/F W/U.S./U.S./G.J. Frederick, M.D.Original record filed in drawer labeled 'MORLEY-MUELLER'
Sustainable Chemical Processes and Products. New Design Methodology and Design Tools
No full textThe current chemical industry is not sustainable, which leads to the fact that innovation of chemical processes and products is too often hazardous for society in general and the environment in particular. It really is a challenge to implement sustainability considerations in the design activities of chemical engineers. Therefore, the main question of this thesis is: how can a trained chemical engineer develop a conceptual design of a chemical process or a chemical product in such a way that the final result clearly contributes to sustainable development? This question is answered after a profound discussion about the current chemical engineering practice and its relation to the sustainability debate. This dissertation claims that sustainable development of chemical engineering practices requires a general design methodology accompanied by a set of design tools. Such a combination of methodology and tools does not exist in the chemical engineering field. The author developed a new design methodology and seven new design tools that enable the incorporation of sustainability issues into the design practice of the chemical engineering field. The application and validity of the methodology and its tools are shown in seven, mainly industrial, case studies.Applied Science
Free-lagrange simulations of shock/bubble interaction in shock wave lithotripsy
No full textA Free-Lagrange CFD code is used to model the near-field interactions between a lithotripter shock wave and a single spherical air bubble in water in axisymmetric form. The shock wave interaction causes the bubble to collapse and undergo jetting which consequently generates a blast wave into the surrounding water due to a liquid-liquid impact. Following impact, the bubble attains a toroidal shape and undergoes subsequent expansion and collapse. A detailed description of the shock/bubble interaction event is given, which includes both primary and secondary collapse. Near-field pressure-time histories are presented
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