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Disease activity measures in adult patients with JIA : a systematic review
No full textTrabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2023A Artrite Idiopática Juvenil (AIJ) é um termo que engloba várias doenças reumáticas crónicas de causa desconhecida e que, no seu conjunto, são as doenças reumáticas crónicas mais comuns na criança que, com frequência, se mantêm ativas na idade adulta. Contudo, não existem critérios específicos validados para medir a atividade da doença em adultos com AIJ, nem recomendações para o tratamento em idade adulta, o que pode ter um impacto negativo importante na transição de cuidados destes doentes para os serviços de adultos. Estudos prévios e revisões sistemáticas, de intervenções terapêuticas focaram-se na idade pediátrica, incluindo na seleção e medição de outcomes.
O nosso objetivo é perceber quais são as escalas mais usadas para medir a atividade da doença, em doentes adultos com AIJ, ao longo do tempo.
Realizámos uma revisão sistemática da literatura reportada de acordo com os critérios PRISMA. A pesquisa foi realizada via MEDLINE e Web of Science para estudos originais em inglês, na população com AIJ e mais de 18 anos, publicados depois dos anos 2000.
69 artigos cumpriram os critérios de inclusão. 53,6% mediram a atividade da doença com um único método, enquanto 46,4% utilizaram mais que um. 56,5% utilizaram Physician’s Global Assessement nesta medição. As escalas mais usadas foram: 43,9% American College of Rheumatology Pediatric criteria (ACR), 27,3% Juvenile Arthritis Disease Activity (JADAS), 15,2% Disease Activity Score (DAS28), 10,6% Wallace Criteria, 1,5% 11- point Numeric Pain Rating Scale (NRS-0-10) e 1,5% Six-point Composite Disease Activity Index (mJPsADA). Entre 2022-2009 a proporção foi semelhante, enquanto antes de 2009 a única escala usada foi o ACR. 65,5% utilizaram o ACR em associação com outra escala, sendo as mais comuns o PGA e o JADAS. 83,3% utilizaram o JADAS em associação com outro método, sendo neste caso, os mais comuns o PGA e ACR. A versão do JADAS mais utilizada foi JADAS71 e JADAS27 (27,8% cada). A avaliação da atividade da doença na AIJ Oligoarticular, Poliarticular e Sistémica teve uma utilização de escalas semelhante. Relativamente às restantes categorias de AIJ, o número de
2
Marta Croca Morais
estudos foi limitativo para uma generalização. Um dos artigos concluiu que o JADAS27 é mais fidedigno que o DAS28 na avaliação da atividade da doença e outro artigo defendeu que o JADAS10 é um melhor parâmetro a refletir doença ativa que o DAS28 em doentes adultos com AIJ.
Assim, a evidência suporta que, apesar de o ACR ser, globalmente, o método mais utilizado, o JADAS teve um crescimento exponencial depois de 2009. A generalização da utilização do JADAS, juntamente com alguma evidência que lhe atribui melhor desempenho que outras ferramentas, torna-o o melhor candidato para ser validada na AIJ em idade adulta.Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in children with an unknown cause, which, frequently, continues active into adulthood. However, there is no specific criteria to measure disease activity and there is an absence of specific treatment recommendations in patients over 18 years old which can have a negative impact in the transition of these patients to adult care.
Previous studies and systematic reviews focused on paediatric population, therefore, our aim is to understand which are the scales used to measure disease activity in adult patients with JIA throughout times.
We conducted a systematic review in accordance with PRISMA. The electronic database search was MEDLINE and Web of Science focused on original studies in English, with JIA patients over 18 years old, published after the year of 2000.
69 articles met the inclusion criteria for review. 53,6% assessed disease activity based on a single method, while 46,4% used more than one. 56,5% utilized Physician’s Global Assessment to evaluate disease activity. The most used scales were 43,9% American College of Rheumatology Pediatric criteria (ACR), 27,3% Juvenile Arthritis Disease Activity (JADAS), 15,2% Disease Activity Score (DAS28), 10,6% Wallace Criteria, 1,5% 11-point Numeric Pain Rating Scale (NRS-0-10) and 1,5% Six-point Composite Disease Activity Index (mJPsADA). Between 2022-2009 the proportion was similar, whereas prior to 2009 the only scale utilized was ACR. 65,5% used ACR in association with another scale, being the most used PGA and JADAS. 83,3% used JADAS in association with another method, most frequently PGA and ACR. The most used version of JADAS was JADAS71 and JADAS27 (27,8% each). Oligoarticular, Polyarticular and Systemic JIA followed a similar utilization of scales to measure disease activity, the others categories of JIA did not have a significant number of studies attributed for a generalization. One of the articles concluded that JADAS27 was more accurate than DAS28 in measuring disease activity in adult population and another one that JADAS10 was a better reflector of active disease than DAS28.
Therefore, evidence supports that even though ACR is globally the most used method to measure disease activity, JADAS had an exponential increase after 2009. The generalization of JADAS, and the scientific evidence that demonstrates its better performance, makes it the better candidate to validate in adult population with JIA
Disease activity measures in adult patients with JIA : a systematic review
No full textTrabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2023A Artrite Idiopática Juvenil (AIJ) é um termo que engloba várias doenças reumáticas crónicas de causa desconhecida e que, no seu conjunto, são as doenças reumáticas crónicas mais comuns na criança que, com frequência, se mantêm ativas na idade adulta. Contudo, não existem critérios específicos validados para medir a atividade da doença em adultos com AIJ, nem recomendações para o tratamento em idade adulta, o que pode ter um impacto negativo importante na transição de cuidados destes doentes para os serviços de adultos. Estudos prévios e revisões sistemáticas, de intervenções terapêuticas focaram-se na idade pediátrica, incluindo na seleção e medição de outcomes.
O nosso objetivo é perceber quais são as escalas mais usadas para medir a atividade da doença, em doentes adultos com AIJ, ao longo do tempo.
Realizámos uma revisão sistemática da literatura reportada de acordo com os critérios PRISMA. A pesquisa foi realizada via MEDLINE e Web of Science para estudos originais em inglês, na população com AIJ e mais de 18 anos, publicados depois dos anos 2000.
69 artigos cumpriram os critérios de inclusão. 53,6% mediram a atividade da doença com um único método, enquanto 46,4% utilizaram mais que um. 56,5% utilizaram Physician’s Global Assessement nesta medição. As escalas mais usadas foram: 43,9% American College of Rheumatology Pediatric criteria (ACR), 27,3% Juvenile Arthritis Disease Activity (JADAS), 15,2% Disease Activity Score (DAS28), 10,6% Wallace Criteria, 1,5% 11- point Numeric Pain Rating Scale (NRS-0-10) e 1,5% Six-point Composite Disease Activity Index (mJPsADA). Entre 2022-2009 a proporção foi semelhante, enquanto antes de 2009 a única escala usada foi o ACR. 65,5% utilizaram o ACR em associação com outra escala, sendo as mais comuns o PGA e o JADAS. 83,3% utilizaram o JADAS em associação com outro método, sendo neste caso, os mais comuns o PGA e ACR. A versão do JADAS mais utilizada foi JADAS71 e JADAS27 (27,8% cada). A avaliação da atividade da doença na AIJ Oligoarticular, Poliarticular e Sistémica teve uma utilização de escalas semelhante. Relativamente às restantes categorias de AIJ, o número de
2
Marta Croca Morais
estudos foi limitativo para uma generalização. Um dos artigos concluiu que o JADAS27 é mais fidedigno que o DAS28 na avaliação da atividade da doença e outro artigo defendeu que o JADAS10 é um melhor parâmetro a refletir doença ativa que o DAS28 em doentes adultos com AIJ.
Assim, a evidência suporta que, apesar de o ACR ser, globalmente, o método mais utilizado, o JADAS teve um crescimento exponencial depois de 2009. A generalização da utilização do JADAS, juntamente com alguma evidência que lhe atribui melhor desempenho que outras ferramentas, torna-o o melhor candidato para ser validada na AIJ em idade adulta.Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in children with an unknown cause, which, frequently, continues active into adulthood. However, there is no specific criteria to measure disease activity and there is an absence of specific treatment recommendations in patients over 18 years old which can have a negative impact in the transition of these patients to adult care.
Previous studies and systematic reviews focused on paediatric population, therefore, our aim is to understand which are the scales used to measure disease activity in adult patients with JIA throughout times.
We conducted a systematic review in accordance with PRISMA. The electronic database search was MEDLINE and Web of Science focused on original studies in English, with JIA patients over 18 years old, published after the year of 2000.
69 articles met the inclusion criteria for review. 53,6% assessed disease activity based on a single method, while 46,4% used more than one. 56,5% utilized Physician’s Global Assessment to evaluate disease activity. The most used scales were 43,9% American College of Rheumatology Pediatric criteria (ACR), 27,3% Juvenile Arthritis Disease Activity (JADAS), 15,2% Disease Activity Score (DAS28), 10,6% Wallace Criteria, 1,5% 11-point Numeric Pain Rating Scale (NRS-0-10) and 1,5% Six-point Composite Disease Activity Index (mJPsADA). Between 2022-2009 the proportion was similar, whereas prior to 2009 the only scale utilized was ACR. 65,5% used ACR in association with another scale, being the most used PGA and JADAS. 83,3% used JADAS in association with another method, most frequently PGA and ACR. The most used version of JADAS was JADAS71 and JADAS27 (27,8% each). Oligoarticular, Polyarticular and Systemic JIA followed a similar utilization of scales to measure disease activity, the others categories of JIA did not have a significant number of studies attributed for a generalization. One of the articles concluded that JADAS27 was more accurate than DAS28 in measuring disease activity in adult population and another one that JADAS10 was a better reflector of active disease than DAS28.
Therefore, evidence supports that even though ACR is globally the most used method to measure disease activity, JADAS had an exponential increase after 2009. The generalization of JADAS, and the scientific evidence that demonstrates its better performance, makes it the better candidate to validate in adult population with JIA
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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