1,352 research outputs found
A study of the behaviour and interactions of the novel FERM protein Willin
No full textWillin is a novel member of the Four-point-one Ezrin Radixin Moesin
(FERM) protein superfamily, containing an N-terminal FERM domain most like the
Ezrin-Radixin-Moesin (ERM) family but also the closely related protein Merlin.
Willin was initially discovered as a yeast two-hybrid binding partner of
neurofascin155, and this interaction has now been confirmed by both co-localisation
studies and the use of two different biochemical methods. Like neurofascin155,
Willin also localises to detergent resistant membranes, and like the ERM family, it is
able to bind to phospholipids. The expression of Willin appears to be toxic as the
production of cell-lines stably expressing Willin proved to be not possible and this
appears to be because it induces apoptosis in cultured cells. This is a proliferation
control function consistent with the suggestion that Willin is the human homologue of the Drosophila tumour suppressor ‘Expanded’. Three antibodies to Willin were also characterised and a novel splice variant, Willin2, subcloned into a GFP-tagged
plasmid for comparison with the original form
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Letter to Philippe-Antoine Merlin, 1802 November 12.
No full textLetter to Philippe-Antoine Merlin, concerning a conflict involving charges of plagarism between the author and C. Laucuouque, dated "21 brumaire, an 11." The author's signature is not entirely legible. Accompanying enveloped shows traces of red wax seal
Molière .· Stage and Study, Essays in honour of W. G. Moore, Edited by W. D. Howarth and Merlin Thomas
No full textVenesoen Constant. Molière .· Stage and Study, Essays in honour of W. G. Moore, Edited by W. D. Howarth and Merlin Thomas. In: Revue belge de philologie et d'histoire, tome 54, fasc. 2, 1976. Histoire (depuis l'Antiquité) — Geschiedenis (sedert de Oudheid) pp. 655-659
Molière .· Stage and Study, Essays in honour of W. G. Moore, Edited by W. D. Howarth and Merlin Thomas
No full textVenesoen Constant. Molière .· Stage and Study, Essays in honour of W. G. Moore, Edited by W. D. Howarth and Merlin Thomas. In: Revue belge de philologie et d'histoire, tome 54, fasc. 2, 1976. Histoire (depuis l'Antiquité) — Geschiedenis (sedert de Oudheid) pp. 655-659
The RUTI trial: a feasibility study exploring Chinese herbal medicine for the treatment of Recurrent Urinary Tract Infections
No full textEthnopharmacological relevanceChinese herbal medicine (CHM) is a widely used traditional intervention that may have a role to play in addressing the global problem of antimicrobial resistance in conditions such as recurrent urinary tract infections (RUTIs). Aim of the studyTo evaluate the feasibility of administering standardised and individualised formulations of CHM for RUTIs as a Clinical Trial of an Investigational Medicinal Product (CTIMP) within primary care of the UKs National Health Service (NHS).Materials and methodsRegulatory approval was applied for a placebo controlled, double blinded randomised controlled feasibility trial comparing a) standardised CHM vs placebo administered via General practitioners, and b) individualised CHM vs placebo administered by an experienced CHM practitioner. Primary feasibility outcomes included: gaining regulatory approval, recruitment, randomisation, retention, safety and the relevance of outcomes measures. ResultsRegulatory approval for testing CHM as a CTIMP was successfully obtained. Recruitment to the trial was slow and non-NHS self-help networks were required to find participants for the individualised arm (n=31). Retention and data collection in the standardised arm (n= 30) were problematic, but these were acceptable in the individualised arm. The use of a daily symptom diary was not a suitable outcome measure for women with continuous infection. Other measures showed promising preliminary data for the individualised arm on improvement in symptoms, and reduction in antibiotic use during and after the trial.ConclusionCHM can fulfil the demanding requirements of a CTIMP study but it may not be feasible at this point in time to recruit and treat via NHS primary care. However acceptable rates of recruitment and retention via self-help groups and promising preliminary results in the individualised arm suggest it would be worth testing this approach in a full trial.<br/
Nurturing Biophilia: Merlin and Sanderling
No full textThe author develops a narrative of Merlin predation to illustrate the growth of biophilia. Initially descriptive, the story evolves by following an iterative process of questioning and relationship building, which leads to an informed and purposeful application of biophilia
The Beginning of Arthur and Merlin
No full textxiii, 34 p.The author explains the origin and literary inspiration for an original story of Arthur and Merlin for young readers
Entangled Lives: How Fungi Make Our Worlds, Change Our Minds, and Shape Our Futures
No full textMerlin Sheldrake, Biologist, speaker, and New York Times best-selling author. - Thinking about fungi makes the world look different. Most fungi live out of sight, yet make up a massively diverse kingdom of organisms that support and sustain nearly all living systems. Fungi throw our concepts of individuality and even intelligence into question. They can change our minds, heal our bodies, and help remediate environmental disaster. In this talk, Merlin will discuss the ways these extraordinary organisms – and our relationships with them – change our understanding of the planet on which we live, and the ways that we think, feel, and behave.https://scholarworks.boisestate.edu/ideas_of_nature_gallery/1041/thumbnail.jp
Merlin and Nimiane : the unifying force for the national unity of Britain at the waning of the Middle Ages as depicted by an anonymous author of the fifteenth-century "Prose Merlin"
No full textThe article analyses a special portrayal of the relationship between Merlin and Nimiane in the English fifteenth-century Prose Merlin. The power couple escapes from their previously distinct and usually dubious renditions to perform a new function that serves the nation-building of a reviving civilization. The political and religious inclinations of the anonymous author are visible in their almost impeccable conduct towards their sovereigns, God, and themselves. The article analyses the unique presentation of the two in the light of the political and social circumstances of the waning of the Middle Ages in Britain and contrasts them with a short analysis of other medieval portrayals of the couple
Some observations on 'relatio' and 'demonstratio' in the Middle Ages: A Metalinguistic Glance at a few Texts od Ockham.
No full textThe present contribution deals with some meanings and uses of the terms relatio and demonstratio during the Middle Ages, in a very particular and narrow perspective. Two essential steps for the discussion are proposed: the first part summarises the grammatical observations contained in the Greek and Latin treatises on grammar written between the 2nd and 6th century, whereas the second part discusses two texts and a selection of a few quotations of one particular author, interestingly linked to both the concepts and terms of relatio and demonstratio, relativus and demonstrativus, from different points of view: William of Ockham (henceforth simply Ockham, as he is traditionally called), philosopher, theologian and Franciscan friar, born in 1285 in Ockham and dying in Munich in 1347. The reading of the selected texts, involving some discussion on demonstrative and relative pronouns, seems to suggest that at least two traditions are involved: on the one hand, the philosophical (logical and theological) perspective, mostly based on a long-standing tradition coming from Aristotle, and on the other, the grammatical and metalinguistic heritage, derived from the work of ancient grammarians of the Hellenistic era. This second approach is the focus of the analysis and comments
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