1,722,428 research outputs found

    Gynecological minimally invasive approach and medical therapy

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    Minimally invasive surgery (MIS) has numerous benefits including shorter length of hospital stay, faster return to normal activity, reduced rate of surgical site infections, less postoperative pain, less blood loss, and reduced incidence of venous thromboembolus, sepsis, and postoperative ileus, especially in women with high BMI (body mass index). In this moment, with COVID-19 infection hitting the world, reducing hospitalization has represented a great advantage.1-3 Minimally invasive surgery can be associated with longer operative times and longer operating room (OR) times.4 MIS has been shown to decrease overall complications when compared with open surgery:5 this is especially true for women with higher body mass index (BMI), which is independently associated with significantly higher rates of venous thromboembolus and wound infection in women who had laparotomy.2 Based on the well-documented advantages over abdominal hysterectomy, the American College of Obstetricians and Gynecologists recommends that minimally invasive approaches (vaginal or laparoscopic, including robot-assisted), should be performed anyway, whenever feasible.6 In this special issue of Minerva Obstetrics and Gynecology, the contributions dealing with the topics of urogynecology, with reference to minimally invasive cancer surgery, underlined that MIS and medical treatment must be preferred in patients when possible. In particular, Monti et al.7-9 dealt with the topic of urinary incontinence and the possible treatments for CIN; D’Oria et al.10 addressed the issue of non-invasive treatment of vulvovaginal atrophy in menopause; Bogani et al.11 approached the subject of minimally invasive surgery in cervical cancer; Casarin et al.12 dealt with minilaparoscopy in gynecology; D’Alterio et al.13 discussed the role of microbiome in the pathogenesis of endometriosis; Muzii et al.14 addressed the topic of endometriosisassociated infertility; and Milliken et al.15 dealt with the issue of surgery in vulval cancer. Our hope is that this special issue will improve clinical practice and help clinicians in their clinical activity in this pandemic period

    Gamete and embryo-fetal origins of adult diseases

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    By putting together the most advanced evidences supporting the 'gamete and embryo-fetal origins of adult diseases' the two editors, Prof. He-Feng Huang and Prof. Jian-Zhong Sheng (Hangzhou, People’s Republic of China) did a great workk....

    Perinatal Stem Cells - Biology, Manufacturing and Translational Medicine

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    This book focuses on a new category of stem cells derived from perinatal tissue, including amniotic fluid, fetal membranes, umbilical cord, and placental tissue...

    Cell Migration - Methods and Protocols

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    As the title suggests, this book presents several techniques to study cells migration in vivo, in vitro, ex vivo and with different model systems to dissect many of the biochemical and biophysical properties (at both molecular and cellular levels) involved in the dynamics of migration and cell-to-cell communication..

    I manoscritti sul "chiuso" e le "arie" (1795-1799). A cura di Maria Teresa Monti. in L. Spallanzani, Edizione Nazionale delle Opere, parte VI (Manoscritti), vol. II, tomo I (-IV).

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    Il secondo volume dei “Manoscritti” (in Edizione Nazionale) di Lazzaro Spallanzani presenta in quattro tomi (2017-2019) l’intero corpus delle carte (protocolli, bozze e “ristretti”) che l’autore compose in occasione della sua seconda indagine sul “chiuso” e le “arie”, cioè sulla respirazione animale e vegetale e sulla chimica dei gas. La presente edizione, critica e annotata, mantiene di quell’inchiesta l’intreccio tematico costitutivo, ricostruendo però l’ordine cronologico dei documenti e assicurandone la miglior leggibilità. Nessuna delle numerose ricerche che impegnarono Spallanzani fu concentrata in un lasso di tempo così breve (6 gennaio 1795-4 febbraio 1799) per una produzione così imponente di appunti, riassunti e prove di scrittura narrativa. In nessun altro caso i risultati conseguiti andarono tanto oltre il livello raggiunto dalla comunità intellettuale coeva e furono tanto intriganti ed intricati al punto da bloccare (molto più della morte) la compilazione e la pubblicazione del grande trattato promesso. Lo scienziato avanzò infatti la sede della respirazione dai polmoni alla cute dell’animale vivo, dall’animale morto all’organo espiantato, dal pezzo intatto alla parte cotta o trattata, dal tessuto integro alle fibre in decomposizione. In caccia frenetica del limite (e alle prese con dati riottosi alla regolarità di ogni legge), Spallanzani fu lavoisieriano e post-lavoisieriano. La scoperta della respirazione tissutale proiettò la sua fisiologia nella biochimica di un corpo disorganizzato, dove è lo scambio gassoso a identificare per organo ‘respiratorio’ il luogo in cui esso avviene. La funzione della respirazione, tradizionalmente legata alla vita e a una struttura anatomica specifica, perse l’uno e l’altro riferimento, proseguendo oltre la vita e largamente oltre l’organizzazione del corpo. Fu troppo anche per un intellettuale spregiudicato come Spallanzani, che infatti non riuscì a chiudere la partita

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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