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Reply to letter by McIntyre et al.
No full textThe comments by McIntyre et al.1 are interesting and
certainly provide insights into additional mechanisms whereby
inhibitors of the vascular endothelial growth factor (VEGF)/
VEGF receptor system impact cardiovascular disease. With
respect to hypertension, experimental and clinical evidence
indicates that the blood pressureeelevating effect of VEGF
inhibitors (VEGFIs) is rapid, occurring within 1-2 days after
starting treatment. This suggests that physiological processes
regulating acute blood pressure responses are activated. From
a vascular viewpoint, such phenomena involve acute vasodilation
and reduced vasomotor tone, processes regulated primarily
by activation of endothelial nitric oxide synthase and
release of nitric oxide (NO), a potent vasodilator. In addition,
activation of the sympathetic nervous system plays a fundamental
role in acute changes in blood pressure. Although there
is extensive experimental evidence demonstrating a role for
NO in VEGFI-mediated hypertension, less is known about
the role of the nervous system. However, there is some indication
that activation or dysregulation of the nervous system
by VEGF inhibition may impact blood pressure regulation,
with studies showing impaired autonomic regulation of
resistance arteries in mice with low levels of VEGF.2 Some
studies have also shown that VEGFIs are neurotoxic and as
such could influence neural control of blood pressure.3
However, other studies failed to demonstrate any significant
effect of VEGFIs on the sympathetic nervous system, because
plasma catecholamine levels were unchanged in sunitinibtreated
mice with severe hypertension.4 The prospective pilot
study by McIntyre et al.1 is certainly timely and should
shed light on a potential relationship between bevacizumab
and autonomic nervous system function in humans. Thepreliminary data,1 although certainly interesting, unfortunately
do not reveal anything about the effects on blood
pressure. It would be important to know whether heart rate
changes observed in the McIntyre et al. study parallel blood
pressure responses. Hopefully, future studies by these researchers
will address this important aspect so that a better
understanding of the putative role of the autonomic system in
VEGFI-induced hypertension can be unraveled
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Assessment and pathophysiology of microvascular disease: recent progress and clinical implications
Get PDFThe development of novel, non-invasive techniques and standardization of protocols to assess microvascular dysfunction have elucidated the key role of microvascular changes in the evolution of cardiovascular (CV) damage, and their capacity to predict an increased risk of adverse events. These technical advances parallel with the development of novel biological assays that enabled the ex vivo identification of pathways promoting microvascular dysfunction, providing novel potential treatment targets for preventing cerebral-CV disease. In this article, we provide an update of diagnostic testing strategies to detect and characterize microvascular dysfunction and suggestions on how to standardize and maximize the information obtained from each microvascular assay. We examine emerging data highlighting the significance of microvascular dysfunction in the development CV disease manifestations. Finally, we summarize the pathophysiology of microvascular dysfunction emphasizing the role of oxidative stress and its regulation by epigenetic mechanisms, which might represent potential targets for novel interventions beyond conventional approaches, representing a new frontier in CV disease reduction
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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