24 research outputs found
La verità visibile nella natura e nella scrittura. Sul baco da seta di Khamis bar Qardahe (fine del XIII secolo)
No full textKhamis bar Qardaḥe was an East Syrian author active in the last decades of the 13th century, probably a representative member of the East-Syrian community at the court camp of the Il-Khans, and somehow connected with the town of Arbela. In the present article, his poetic work is presented in the broader context of the so-called ‘Syriac Renaissance’, as an example of late East-Syriac literature profoundly influenced by Persian poetry. The poem On the Silk-Worm is here critically edited and translated for the first time into a European language. Its complicated imagery turns out to be an interesting mélange of philosophical concepts, meta-literary reflection – poetry as a way to knowledge and salvation –, Christian themes – including the virginal conception of Mary –, and Persian, possibly Sufic, motifs. The monorhyme poem is rich with sound figures such as alliteration and etymological play
La verità visibile nella natura e nella scrittura: Sul baco da seta di Khamis bar Qardaḥe (fine del XIII secolo)
No full textKhamis bar Qardaḥe was an East Syrian author active in the last decades of the 13th century, probably a representative member of the East-Syrian community at the court camp of the Il-Khans, and somehow connected with the town of Arbela. In the present article, his poetic work is presented in the broader context of the so-called ‘Syriac Renaissance’, as an example of late East-Syriac literature profoundly influenced by Persian poetry. The poem On the Silk-Worm is here critically edited and translated for the first time into a European language. Its complicated imagery turns out to be an interesting mélange of philosophical concepts, meta-literary reflection – poetry as a way to knowledge and salvation –, Christian themes – including the virginal conception of Mary –, and Persian, possibly Sufic, motifs. The monorhyme poem is rich with sound figures such as alliteration and etymological play
Steroid therapy for a case of severe drug-induced cholestasis.
No full textOBJECTIVE: To report a severe case of cholestatic liver disease successfully treated with corticosteroids following combined therapy with clarithromycin and nimesulide.
CASE SUMMARY: A 15-year-old girl was admitted with cholestasis probably related to treatment with clarithromycin and nimesulide for an upper respiratory tract infection. Other causes of liver disease (infections, metabolic liver disorders, genetic cholestatic syndromes, autoimmune diseases, primary biliary tract disorders) were excluded. Liver biopsy showed a severe canalicular cholestasis with bile plugs in dilated bile canaliculi, giant cell transformation, and portal and lobular infiltrate. An objective causality assessment suggested that cholestasis was probably related to clarithromycin and/or nimesulide use. No benefit was derived from a course of ursodeoxycholic acid therapy. Since the patient experienced a progressive worsening in cholestasis, prednisone was started after 20 days. This therapy was promptly followed by improvement in clinical and laboratory test results. After 2 months of prednisone treatment, the patient became symptom-free with normal liver function tests.
DISCUSSION: The manifestations of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic hypertransaminemia to fulminant hepatic failure. No specific treatment for drug-induced hepatotoxicity exists. Early recognition and drug withdrawal are the keys to management of hepatotoxicity, but in some cases, liver disease may persist despite discontinuation of the drug. Possible advantages of corticosteroid therapy have not been well demonstrated.
CONCLUSIONS: Application of the Naranjo probability scale indicates a probable relationship between cholestasis and nimesulide plus clarithromycin use. This case draws attention to a possible therapeutic option for some cases of drug-induced hepatotoxicity that show a severe course without any sign of improvement
I&I - Cryptocurrency with Gian Volpicelli
No full textThis week is our April edition of Incentives and Instincts, a monthly series in which I speak with economist and friend, Bryce Ward, about some of the broader issues facing our society.
In this conversation we cover cryptocurrency: what is it and what do you need to know about it? To help answer these questions, we are joined by Gian Volpicelli, senior writer at WIRED and author of Cryptocurrency: How Digital Money Could Transform Finance.https://scholarworks.umt.edu/anewangle_podcasts/1240/thumbnail.jp
Correction to: Patients in intensive care unit for COVID-19 pneumonia: the lung ultrasound patterns at admission and discharge. An observational pilot study (The Ultrasound Journal, (2021), 13, 1, (10), 10.1186/s13089-021-00213-x)
No full textFollowing publication of the original article [1], we were notified that the first and last author names have been swapped. The original article has been corrected
Ruta graveolens L. Induces Death of Glioblastoma Cells and Neural Progenitors, but Not of Neurons, via ERK 1/2 and AKT Activation
No full textGlioblastoma multiforme is a highly aggressive brain tumor whose prognosis is very poor. Due to early invasion of brain parenchyma, its complete surgical removal is nearly impossible, and even after aggressive combined treatment (association of surgery and chemo- and radio-therapy) five-year survival is only about 10%. Natural products are sources of novel compounds endowed with therapeutic properties in many human diseases, including cancer. Here, we report that the water extract of Ruta graveolens L., commonly known as rue, induces death in different glioblastoma cell lines (U87MG, C6 and U138) widely used to test novel drugs in preclinical studies. Ruta graveolens' effect was mediated by ERK1/2 and AKT activation, and the inhibition of these pathways, via PD98058 and wortmannin, reverted its antiproliferative activity. Rue extract also affects survival of neural precursor cells (A1) obtained from embryonic mouse CNS. As in the case of glioma cells, rue stimulates the activation of ERK1/2 and AKT in A1 cells, whereas their blockade by pharmacological inhibitors prevents cell death. Interestingly, upon induction of differentiation and cell cycle exit, A1 cells become resistant to rue's noxious effects but not to those of temozolomide and cisplatin, two alkylating agents widely used in glioblastoma therapy. Finally, rutin, a major component of the Ruta graveolens water extract, failed to cause cell death, suggesting that rutin by itself is not responsible for the observed effects. In conclusion, we report that rue extracts induce glioma cell death, discriminating between proliferating/undifferentiated and non-proliferating/differentiated neurons. Thus, it can be a promising tool to isolate novel drugs and also to discover targets for therapeutic intervention
Pedagogisti e educatori tra scuola e università
No full textDue to his firm belief in the value of a close cooperation between school and university, and also in the commitment to the creation of a form of emancipatory and democratic education, the author collected profiles and accounts relating to his personal meeting with educationalists (as well as philosophers who were interested in the topic of education) and scholars fighting together to create a liberating school accessible to everyone. Therefore, the pages on Raffaele Resta, Giovanni Calò, Franco Lombardi and Luigi Volpicelli (both former teachers of the author), Dina Bertoni Jovine, Remo Cantoni, Marco Olivetti, Angelo Broccoli, Dina Tomasi, Santoni Rugiu, Remo Fornaca are joined by those on the school principals Virgilio Zangrilli, Giacomo Santucci, Giustino Broccolini (who then became associate professor). All of these are generous people, engaged in wide prospects and constructive, educational and civil programs, without falling victim to the narrow technical specializations or lack of horizons
A Comparison of the Effects of the Opioid Antagonists Naltrexone, Naltrindole, and β-Funaltrexamine on Ethanol Consumption in the Rat
No full text静脩 Vol. 3 No. 6 (1967.2) [全文]
No full text京都大学附属図書館報学生時代の思い出 / 堀江保蔵パリ大学法経学部図書館を利用して / 藤田久一VOLPICELLIについてヨーロッパの大学図書館 - 講演 -医学図書館のContents Service本学雑誌目録出来る - 京都大学学術雑誌総合目録:人文科学欧文篇資料紹介:U.S.Library of Congress: A catalog of books represented by Library of Congress printed cards, issued to July 31, 1942. 167 v. 1942 - 46資料紹介:U.S.Library of Congress: Supplement; ･･･ cards issued Aug. 1, 1042 - Dec. 31, 1947. 42 v. 1960資料紹介:U.S.Library of Congress: Author catalog; a cumulative list of works represented by Library of Congress printed cards, 1948 - 1952. 24 v. 1960資料紹介:U.S.Library of Congress: The national union catalog; a cumulative author list representing Library of Congress printed cards and titles reported by other American libraries, 1953 - 1957. 28 v. 1961資料紹介:U.S.Library of Congress: The national union catalog; a cumulative author list representing Library of Congress printed cards and titles reported by other American libraries, 1958 - 1962. 54 v. 1963経済学部図書室あとが
Chaperone proteins as ameliorators of alpha-synuclein-induced synaptic pathologies: Insights into Parkinson's disease
No full text© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Banks, S. M. L., Medeiros, A. T., Sousa, R., Lafer, E. M., & Morgan, J. R. Chaperone proteins as ameliorators of alpha-synuclein-induced synaptic pathologies: Insights into Parkinson's disease. Neural Regeneration Research, 16(6), (2021): 1198-1199, doi:10.4103/1673-5374.300431.α-Synuclein accumulation causes synaptic vesicle trafficking defects and may underlie neurodegenerative disorders: Neurodegenerative disorders, such as Parkinson’s disease (PD) and other synucleinopathies, impact the lives of millions of patients and their caregivers. Synucleinopathies include PD, dementia with Lewy Bodies (DLB), multiple system atrophy, and several Alzheimer’s Disease variants. They are clinically characterized by intracellular inclusions called Lewy Bodies, which are rich in atypical aggregates of the protein α-synuclein. While dopaminergic neurons in the substantia nigra are particularly susceptible to α-synuclein-induced aggregation and neurodegeneration, glutamatergic neurons in other brain regions (e.g. cortex) are also frequently affected in PD and other synucleinopathies (Schulz-Schaeffer 2010). Several point mutations in the α-synuclein gene (SNCA), as well as duplication/triplication of SNCA, are linked to familial Parkinson’s disease. In animal models, these genetic alterations lead to overexpression and aberrant accumulation of α-synuclein within neurons, and eventually to neurodegeneration. Interestingly, in both animal models and human patients, α-synuclein aggregation often occurs at neuronal synapses and within axons prior to the appearance of larger aggregates (i.e. Lewy bodies) and other signs of neurodegeneration (Schulz-Schaeffer 2010; Volpicelli-Daley et al., 2011). The level of synaptic aggregation of α-synuclein is highly correlated with greater cognitive deficits in PD and DLB patients (Schulz-Schaeffer 2010). Thus, it is essential to understand how excess α-synuclein impacts synapses, as this may represent an early stage in the neurodegenerative disease progression and thus a viable target for therapeutic intervention, particularly with respect to cognitive impairment.The present work was supported by a grant from the National Institutes of Health National Institute of Neurological Disorders and Stroke/National Institute on Aging (NIH NINDS/NIA R01NS078165 to JRM) and National Institute of General Medical Sciences (NIH/NIGMS Grant R01GM118933 to EML and RS)
