148 research outputs found
Fractal Analysis of Elastographic Images for Automatic Detection of Diffuse Diseases of Salivary Glands: Preliminary Results
No full textThe geometry of some medical images of tissues, obtained by elastography and ultrasonography, is characterized in terms of
complexity parameters such as the fractal dimension (FD). It iswell known that in any image there are very subtle details that are not
easily detectable by the human eye. However, in many cases like medical imaging diagnosis, these details are very important since
they might contain some hidden information about the possible existence of certain pathological lesions like tissue degeneration,
inflammation, or tumors. Therefore, an automatic method of analysis could be an expedient tool for physicians to give a faultless
diagnosis. The fractal analysis is of great importance in relation to a quantitative evaluation of “real-time” elastography, a procedure
considered to be operator dependent in the current clinical practice.Mathematical analysis reveals significant discrepancies among
normal and pathological image patterns. The main objective of our work is to demonstrate the clinical utility of this procedure on
an ultrasound image corresponding to a submandibular diffuse pathology
Design and evaluation of neuroregenerative properties of 4D hydrogel scaffolds
No full textUnderstanding and controlling the interactions that occur between cells and engineered materials (i.e. attachment-detachment, or that influence cell development, function or fate) are central challenges towards progress in the development of biomedical devices and regenerative medicine therapies. A particularly complex system to translate in vitro is that of the dorsal root ganglion (DRG), an interesting research target due to its relevance in peripheral nerve repair, and to its connection to the non-regenerative central nervous system (CNS). Severe peripheral nerve injuries have a limited regenerative capacity, with interventions typically not leading to full functional recovery. Ways to improve functional recovery include engineering devices that connect to both injured sides, having both cell growth guiding properties and a gradient contour to control the extent of cell-scaffold interactions. Direct ink writing (DIW) is prominent among fabrication techniques relevant to tissue engineering due to its versatility in terms of the range of materials that can be used and the limitless geometries that are easily programmed. This thesis describes three different in vitro systems, representing increasing functionality towards next generation 4D scaffolds for nerve reconstruction in vitro or nerve regeneration in vivo. The first takes advantage of cell-extracellular matrix interactions and presents an extracellular matrix (ECM)-mimetic surface treatment which, combined with DIW scaffolds of a wide range of geometries and a “blank-slate” hydrogel (pHEMA), leads to a means to exert control on the degree of cell-scaffold interactions, and manipulate cell culture development in 4D. The second explores a different class of scaffolds, compressively buckled mesostructures, which can be used as high-strain cellular frameworks leading to interesting cell behavior depending on scaffold strain and geometric aspect ratio. Further, this approach allows for the incorporation of increased functionality into these mesostructures, as they can function as electronic scaffolds for stimulation and recording of action potentials from DRG cells. Finally, the third approach combines efforts of the first two projects, building upon the ink and surface chemistries explored in the first, and the geometries explored in the second, adding a bioactive inorganic composite to create selectively growth compliant scaffolds that generate a hierarchal reorganization of DRG cells in culture mimicking that of a nerve. With the possibility of extending the complexity of these scaffolds by including controlled degradation, this last approach provides important guidelines to developing effective 4D scaffolds for nerve regeneration.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01The student, Adina Badea, accepted the attached license on 2017-12-04 at 16:17.The student, Adina Badea, submitted this Dissertation for approval on 2017-12-04 at 16:38.This Dissertation was approved for publication on 2017-12-08 at 12:29.DSpace SAF Submission Ingestion Package generated from Vireo submission #11838 on 2019-08-22 at 16:17:41Made available in DSpace on 2019-08-23T20:44:17Z (GMT). No. of bitstreams: 6
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B.1 Programming mechanical and physicochemical properties of 3D hydrogel cellular microcultures via direct ink writing.pdf: 7230067 bytes, checksum: 0d564f61b0ffc65a1ee5ba0500c6a4eb (MD5)
B.2 Quantitative reflection imaging for the morphology and dynamics of live Aplysia californica pedal ganglion neurons cultured on nanostructured plasmonic crystals.pdf: 1232215 bytes, checksum: 42fd3a0f4b98ccc9affdea3e7bd18bc8 (MD5)
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Previous issue date: 2017-12-08Embargo set by: Seth Robbins for item 112232
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 112232
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La traduction n’est pas qu’une traduction. Quelques propos sur la traduction d’une écriture fragmentaire bilingue: <i>Cuvântul nisiparniţă</i> (<i>Le Mot sablier</i>) de Dumitru Tsepeneag
No full textAbstract
Translation is not mere translation. A few remarks on the translation of a fragmentary bilingual text: Cuvântul nisiparniță (Le Mot sablier/The Hourglass Word) by Dumitru Tsepeneag
The present paper will focus on the translation of a fragmentary bilingual writing. Interested both in his own monolingualism and in the monolingualism of the other (see Derrida 1996, and here mainly the monolingualism of the French reader who should constitute a kind of pseudo-source-audience3), Dumitru Tsepeneag turns his own bilingualism into a topic in his book Cuvîntul nisiparniță (published first in translation as Le Mot sablier in 1984). “This (im)possible appropriation becomes the generating reason of the creation and in the creation, then in the self-translation”; a “writing experience” where the writer cultivates his bilingualism and his biculturalism, and sheds light on the process of translation from a perspective that is at least double: that of the translated42 and self-translated writer, but also that of the translator-writer” (Lungu-Badea 2008, 20). What translation strategy would be appropriate for a book that begins in Romanian and ends in French? We could claim that its destiny is to show how one language replaces another and, consequently, renders translation useless for bilingual users. If this is but an argument for the counter-translation, the French translation, published by the P.O.L. publishing house, does not challenge it. It could respect neither “the psychological intention of the author” (Ladmiral 2006, 140), nor the “semantic intention of the text” (Ladmiral and Lipiansky 1995, 53).</jats:p
Author Correction: WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton
No full textAn amendment to this paper has been published and can be accessed via a link at the top of the paper
Antimicrobial thin films based on ayurvedic plants extracts embedded in a bioactive glass matrix
No full textAyurvedic medicine is one of the oldest medical systems. It is an example of a coherent traditional system which has a time-tested and precise algorithm for medicinal plant selection, based on several ethnopharmacophore descriptors which knowledge endows the user to adequately choose the optimal plant for the treatment of certain pathology. This work aims for linking traditional knowledge with biomedical science by using traditional ayurvedic plants extracts with antimicrobial effect in form of thin films for implant protection. We report on the transfer of novel composites from bioactive glass mixed with antimicrobial plants extracts and polymer by matrix-assisted pulsed laser evaporation into uniform thin layers onto stainless steel implant-like surfaces. The comprehensive characterization of the deposited films was performed by complementary analyses: Fourier transformed infrared spectroscopy, glow discharge optical emission spectroscopy, scanning electron microscopy, atomic force microscopy, electrochemical impedance spectroscopy, UV-VIS absorption spectroscopy and antimicrobial tests. The results emphasize upon the multifunctionality of these coatings which allow to halt the leakage of metal and metal oxides into the biological fluids and eventually to inner organs (by polymer use), to speed up the osseointegration (due to the bioactive glass use), to exert antimicrobial effects (by ayurvedic plants extracts use) and to decrease the implant price (by cheaper stainless steel use)
Refinement operators can be (weakly) perfect
No full textOur aim is to construct a perfect (i.e. minimal and optimal) ILP renement operator for hypotheses spaces bounded below by a most specific clause and subject to syntactical restrictions in the form of input /output variable declarations (like in Progol). Since unfortunately no such optimal refinement operators exist, we settle for a weaker form of optimality and introduce an associated weaker form of subsumption which exactly captures a first incompleteness of Progol's renement operator. We argue that this sort of incompleteness is not a drawback, as it is justified by the examples and the MDL heuristic. A second type of incompleteness of Progol (due to subtle interactions between the requirements of non-redundancy, completeness and the variable dependencies) is more problematic, since it may sometimes lead to unpredictable results. We remove this incompleteness by constructing a sequence of increasingly more complex refinement operators which eventually produces the first (weakly) perfect refinement operator for a Progol-like ILP system
Gamification: Improving Supervisory Control Performance in Highly Automated Air Traffic Control
No full textThe use of automated conflict detection and resolution tools for air traffic control seems inevitable. Air traffic controllers will then take the role of automation supervisors, a role which is generally unsuitable for humans. Gamification, the use of game elements in non-gaming contexts, shows promising results in mitigating the effects of boredom. This project presents and experimentally tests a proposed implementation of gamification within an air traffic control work environment. Fictional aircraft are superimposed among automatically controlled real traffic, thus creating fictional conflicts that need resolving. System supervisors are given the task of supervising the behaviour of a fully automated conflict detection and resolution system while routing fictional aircraft safely and efficiently through the sector, avoiding conflicts with other aircraft (both real and fictional). Experiment results show that the presence of fictional aircraft increased reported concentration levels among participants, as well as improved supervisory control performance.Aerospace Engineerin
The effect of silica fume on early hydration of white Portland cement via fast field cycling-NMR relaxometry
No full textConflict Prevention, Detection, and Resolution in Constrained Very Low-Level Urban Airspace
No full textThe interest for using small aircraft for missions in urban airspace is growing for applications like parcel deliveries. Research shows that conventional airspace structure and conflict detection and resolution techniques are not suitable for main- taining a high level of safety in constrained urban environments, especially when aircraft are restricted to flying within the limits of the road network. The problem at hand becomes even more complex when factoring in cities with topologically organic street networks, thus increasing the probability of crossing and merging traffic flows. Preliminary results show that such networks induce the detection of false-positive conflicts when using classical state- based conflict detection, decreasing the effectiveness of conflict resolution. Velocity-obstacle based conflict resolution methods were able to improve airspace safety, but require further de- velopment in order to handle conflicts in such an unpredictable and constrained environment. Thus, the doctoral project at hand seeks to develop and research improved methods for conflict prevention, detection and resolution in constrained, urban, very low-level urban airspace.Control & Simulatio
Classic and modern methods for detection of serotonin
No full textThe detection of serotonin and other neurotransmitters from different biological
samples (serum, plasma, platelets, urine, saliva, cerebrospinal liquid) are very important in
clinical diagnosis. For this reason, several classic and modern methods for detection of
serotonin were presented in this paper. The advantages and disadvantages of classic methods
(colorimetric, fluorometric, chromatographic methods and immunoassay) were presented.
The new methods (sensors, biosensors, imaging techniques - PET) are also indicated. Electrochemical detection of serotonin is indicated in the scientific literature, using different types of electrodes (glassy carbon electrode, screen printed electrode)
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