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    “Determinación de antibióticos en leche cruda bovina en el centro de acopio de la parroquia Ludo, cantón Sígsig”.

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    Introducción. La leche es un líquido biológico rico en nutrientes, segregado por las glándulas mamarias de las vacas, contiene proteínas, carbohidratos, lípidos, vitaminas, enzimas y hormonas que benefician el desarrollo de niños y adultos. Para garantizar su calidad, la leche debe cumplir ciertos requisitos establecidos en la NTE INEN 9, estos parámetros se evalúan mediante análisis sensoriales, propiedades fisicoquímicas y pruebas microbiológicas para garantizar su seguridad y pureza antes de llegar a las plantas procesadoras lácteas antes de ser consumida en diversas formas y derivados. Objetivo. Detectar residuos de antibióticos betalactámicos, tetraciclinas, sulfonamidas en el centro de acopio de Ludo, Ecuador, para establecer la calidad de la leche cruda bovina que se entrega en las industrias lácteas. Metodología. Se recolectaron muestras de cada proveedor, de tres rutas diferentes, en días aleatorios y mediante el empleo del Kit Test Rapid de Bioeasy se determinó la ausencia o presencia de residuos de antibióticos. Resultados. En el análisis de residuos de antibióticos se obtuvo dos casos positivos de 116 muestras recolectadas, una para betalactámicos y otra para sulfonamidas, las mismas que son utilizadas para tratar distintas patologías que afectan al ganado, por lo que es crucial llevar un registro de los animales tratados y cumplir con los tiempos de retiro de la leche. Conclusión. La presencia de residuos de antibióticos en la leche cruda bovina es preocupante debido a los efectos negativos que pueden ocasionar en la salud humana, como alergias, disbacteriosis, resistencia antimicrobiana y toxicidad, además pueden llevar al rechazo del producto.Introduction. Milk is a biological liquid with high nutrient content produced by the mammary glands of cows; it contains proteins, carbohydrates, lipids, vitamins, enzymes, and hormones that benefit the development of children and adults. To ensure its quality, milk must meet specific requirements established in the Ecuadorian Technical Standard - National Institute of Neoplastic Diseases 9 (NTE INEN by its Spanish acronym). These parameters are evaluated through sensory analysis, physicochemical properties, and microbiological tests to ensure their safety and purity before being processed in dairy plants and consumed in various forms and derivatives. Objective. To detect residues of beta-lactam antibiotics, tetracyclines, and sulfonamides in the cooperative center of Ludo, Ecuador, to establish the quality of raw bovine milk supplied to dairy industries. Methodology. Samples were collected from various suppliers, employing three different routes on random days. Absence or presence of antibiotic residues was determined using the Bioeasy Rapid Test Kit. Results. The analysis of antibiotic residues revealed two positive cases among the 116 collected samples. One case tested positive for beta-lactams, while the other exhibited sulfonamides residues. These substances are used to treat various cattle-related pathologies. Hence, keeping a record of treated animals and complying with milk withdrawal times is crucial. Conclusion. The presence of antibiotic residues in raw bovine milk is concerning due to the adverse effects on human health, including allergies, dysbacteriosis, antimicrobial resistance, and toxicity. It can also lead to the rejection of the product.Trabajo de investigació

    Implementación de un sistema informático controlab para el control de inventario del laboratorio clínico y toxicológico de la facultad de bioquímica y farmacia de la Universidad Católica de Cuenca

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    Los inventarios han sido de gran importancia para el control y monitoreo de productos; así como también rigiéndose a las normativas INEN en el Ecuador; el cual, tiene como requisito la implementación de un sistema de inventario con la finalidad de llevar un mejor orden dentro de cualquier establecimiento. Por ello, se ha visto la necesidad de implementar un sistema de control de inventarios denominado ControLab en el laboratorio de Análisis Clínico y Toxicológico en la facultad de Bioquímica y farmacia de la Universidad Católica de Cuenca, para obtener información del estado actual de los equipos, materiales y reactivos del laboratorio; se hizo uso de inventarios anteriores, modelos de ítems en Excel y físicos, procedimientos para el control de inventario y uso de códigos de barra. El diseño transversal descriptivo permite realizar el estudio sin la manipulación de las variables siendo estas de carácter cualitativo. OBJETIVO: El objetivo de esta investigación fue implementar un sistema informático denominado ControLab para el control de inventario del laboratorio 215 de análisis clínico y toxicológico a través de un lector de códigos de barra. MATERIALES Y MÉTODOS: Materiales utilizados para el desarrollo fue el Software de control de inventario; y la metodología aplicada fue de tipo cualitativo, descriptivo, investigativo y longitudinal. RESULTADOS: Se pudo demostrar que el sistema de control de inventario es fiable y cumple con los requerimientos en el laboratorio, donde se pudo observar que, hay una mayor eficiencia en la gestión de inventarios, reducción de costos, mejora en la toma de decisiones y no existe resistencia al cambio por parte del personal encargado. CONCLUSIÓN: Los resultados obtenidos han confirmado la eficacia y eficiencia de los nuevos procesos, brindando una gestión más ordenada y optimizada de los recursos del laboratorio. Se ha logrado mejorar la trazabilidad de los equipos y suministros, asegurando un mejor control y disponibilidad de los mismos.Inventories are of great importance for the control and monitoring of products, as well as being compliant with the Ecuadorian Institute for Standardization (INEN by its acronym in Spanish), which requires implementing an inventory system to have a better order in any establishment. Therefore, it has been necessary to implement an inventory control system called ControLab at the Clinical and Toxicological Analysis Laboratory in the Faculty of Biochemistry and Pharmacy of the Catholic University of Cuenca. OBJECTIVE: This research aimed to implement a computer system called ControLab for inventory control of laboratory 215 of clinical and toxicological analysis through a barcode reader. MATERIALS AND METHODS: Materials used for the implementation were the inventory control software, and the methodology applied was qualitative, descriptive, investigative, and longitudinal. RESULTS: It was possible to demonstrate that the inventory control system is reliable and meets the requirements in the laboratory, where it was observed that there is greater efficiency in inventory management, cost reduction, improvement in decision making, and there is no resistance to change by the personnel in charge. CONCLUSION: The results obtained have confirmed the effectiveness and efficiency of the new processes, providing more orderly and optimized management of the laboratory's resources. The traceability of equipment and supplies has been improved, ensuring better control and availability.Trabajo de investigació

    Implementación de sistema para el control de inventario del laboratorio de tecnología farmaceútica de la facultad de bioquímica y farmacia de la Universidad Católica de Cuenca

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    INTRODUCCIÓN: En Ecuador los inventarios son fundamentales para satisfacer las operaciones y obtener mayores beneficios, mejor gestión y planificación. Por esta razón se tiene por objeto implementar un sistema de control de inventario en el laboratorio de tecnología farmacéutica. Surge la necesidad de realizar esta investigación porque el manejo manual del inventario impendía su correcto control y la realización de las actividades. OBJETIVO: Implementar un sistema de control de inventario en el laboratorio de tecnología farmacéutica de la facultad de Bioquímica y farmacia de la Universidad Católica de Cuenca. MATERIALES Y MÉTODOS: El diseño de esta investigación será de forma cualitativa. Se basa en un método descriptivo, la información que se utilizará para el desarrollo a partir de un inventario manual con el que contaba en personal de laboratorio. RESULTADOS: El sistema de control de inventario es de gran utilidad para la automatización del stock lo que ayudará analizar oportunamente los procedimientos y normativas a seguir para obtener mejoras. CONCLUSIÓN: La implementación de un sistema de control de inventario es un paso esencial para optimizar los procesos y mejorar el entorno del laboratorio, es mediante el seguimiento y la gestión que se puede garantizar la disponibilidad oportuna de los recursosINTRODUCTION: In Ecuador, inventories are fundamental to satisfy operations and to obtain higher profits, better management, and planning. For this reason, this study aims to implement an inventory control system in the pharmaceutical technology laboratory because the manual handling of the inventory prevented its correct control and the development of other activities. OBJECTIVE: To implement an inventory control system in the pharmaceutical technology laboratory of the Faculty of Pharmacy and Biochemistry of the Catholic University of Cuenca. MATERIALS AND METHODS: The design of this research is qualitative. The descriptive method was used; the information utilized for the development is based on a manual inventory of the laboratory staff. RESULTS: The inventory control system is beneficial for the automation of the stock, which will help to analyze the procedures and regulations to be followed to obtain improvements. CONCLUSION: Implementing f an inventory control system is an essential step to optimize processes and improve the laboratory environment; it is through monitoring and management that the timely availability of resources can be ensured.Trabajo de investigació

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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