3,325 research outputs found
The North is another country. by Nicolas Rothwell
No full texttag=1 data=The North is another country. by Nicolas Rothwell
tag=2 data=Rothwell, Nicolas
tag=3 data=Australian Magazine,
tag=6 data=16/17 November 1996
tag=7 data=20-33.
tag=8 data=NT%TOURISM
tag=10 data=Worse, better, stranger, wilder, but above all different from the rest of the country. Continuing his journey of discovery across Australia's Top half the author stops over in Darwin to hear all the truths and whispers about the North.
tag=11 data=1996/2/8
tag=12 data=96/0316
tag=13 data=CABWorse, better, stranger, wilder, but above all different from the rest of the country. Continuing his journey of discovery across Australia's Top half the author stops over in Darwin to hear all the truths and whispers about the North
IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis
No full textAbstract Studies in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, have shown that B cells markedly influence the course of the disease, although whether their effects are protective or pathological is a matter of debate. EndoS hydrolysis of the IgG glycan has profound effects on IgG effector functions, such as complement activation and Fc receptor binding, suggesting that the enzyme could be used as an immunomodulatory therapeutic agent against IgG-mediated diseases. We demonstrate here that EndoS has a protective effect in myelin oligodendrocyte glycoprotein peptide amino acid 35–55 (MOG35-55)-induced EAE, a chronic neuroinflammatory demyelinating disorder of the central nervous system (CNS) in which humoral immune responses are thought to play only a minor role. EndoS treatment in chronic MOG35-55-EAE did not impair encephalitogenic T cell priming and recruitment into the CNS of mice, consistent with a primary role of EndoS in controlling IgG effector functions. In contrast, reduced EAE severity coincided with poor serum complement activation and deposition within the spinal cord, suggesting that EndoS treatment impairs B cell effector function. These results identify EndoS as a potential therapeutic agent against antibody-mediated CNS autoimmune disorders.</p
Grace S. Fong, Herself an Author : Gender, Agency, and Writing in Late Imperial China, 2008
No full textZufferey Nicolas. Grace S. Fong, Herself an Author : Gender, Agency, and Writing in Late Imperial China, 2008. In: Études chinoises, n°28, 2009. Numéro spécial sur le droit chinois. pp. 243-247
New Necklaces: 400 Designs in Contemporary Jewellery
No full textAfter the successful New Rings and New Earrings, New Necklaces is the third book curated by jeweller and author Nicolas Estrada, from classic forms and materials to the most daring, experimental and surprising ideas, each of the 500 necklaces included in this book has something that makes it unique and relates strongly to today's social, cultural and artistic reality. With prefaces by German jeweller Julia Wild and Leo Caballero, owner of the Barcelona gallery Klimt 02, specialised in contemporary jewellers
Transforming growth factor-beta 1-producing regulatory B cells limit the induction phase of autoimmune neuroinflammation
No full textHow Did I Get to Princess Margaret? (And How Did I Get Her to the World Wide Web?)
No full textThe paper explores the growing use of
tools from the arts and humanities for investigation
and dissemination of social science research.
Emerging spaces for knowledge transfer, such as
the World Wide Web, are explored as outlets for
"performative social science". Questions of ethnics
and questions of evaluation which emerge from
performative social science and the use of new
technologies are discussed. Contemporary thinking
in aesthetics is explored to answer questions
of evaluation. The use of the Internet for productions
is proposed as supporting the collective
elaboration of meaning supported by Relational
Aesthetics.
One solution to the ethical problem of performing
the narrations of others is the use of the writer's
own story as autoethnography. The author queries
autoethnography's tendency to tell "sad" stories and
proposes an amusing story, exemplified by "The
One about Princess Margaret" (see Appendix).
The conclusion is reached that the free and open
environment of the Internet sidelines the usual
tediousness of academic publishing and begins to
explore new answers to questions posed about
the evaluation and ethics of performative social
science
Identification of author profiles through social networks
No full textThe aim of this paper is to compile dictionaries of slang words, abbreviations, contractions, and emoticons to help the pre-processing of texts published in social networks. The use of these dictionaries is intended to improve the results of the tasks related to data obtained from these platforms. Therefore, a hypothesis was evaluated in the task of identifying author profiles (author profiling).Silva, JesúsMaria Santodomingo, Nicolas EliasRomero, LigiaJorge, MarisolHerrera, MaritzaPineda Lezama, Omar Bonerg
Stimulated T cells generate microparticles, which mimic cellular contact activation of human monocytes: differential regulation of pro- and anti-inflammatory cytokine production by high-density lipoproteins.
No full textImbalance in cytokine homeostasis plays an important part in the pathogenesis of chronic inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. We demonstrated that T cells might exert a pathological effect through direct cellular contact with human monocytes/macrophages, inducing a massive up-regulation of the prototypical proinflammatory cytokines IL-1beta and TNF. This mechanism that might be implicated in chronic inflammation is specifically inhibited by high-density lipoproteins (HDL). Like many other stimuli, besides proinflammatory cytokines, the contact-mediated activation of monocytes induces the production of cytokine inhibitors such as the secreted form of the IL-1 receptor antagonist (sIL-1Ra). The present study demonstrates that stimulated T cells generate microparticles (MP) that induce the production of TNF, IL-1beta, and sIL-1Ra in human monocytes; the production of TNF and IL-1beta but not that of sIL-1Ra is inhibited in the presence of HDL. The results were similar when monocytes were stimulated by whole membranes of T cells or soluble extracts of the latter. This suggests that MP carry similar monocyte-activating factors to cells from which they originate. Thus, by releasing MP, T cells might convey surface molecules similar to those involved in the activation of monocytes by cellular contact. By extension, MP might affect the activity of cells, which are usually not in direct contact with T cells at the inflammatory site. Furthermore, this study demonstrates that HDL exert an anti-inflammatory effect in nonseptic activation of human monocytes, not only by inhibiting the production of IL-1beta and TNF but also, by leaving sIL-1Ra production unchanged
Nikolski de Nicolas Dickner. - américanité, archéologie, intertextualité
No full textAuthor treats different dimensions of space in Nicolas Dickner's novel Nikolski. He analyses the way in which the novel ties links between space and family and, furthermore, outlines the role stratification plays in the novel
SCAD-zbMATH-01 Open Access Data Set for Author Name Disambiguation (AND) (Enhanced Version)
No full text<p>This data set contains disambiguated publication data from zbMATH (www.zbmath.org) for use in author name disambiguation (AND). It covers 28321 publications with 33810 authorship records, authored by 2946 distinct authors. Authorship records have been manually annotated with author identifiers.</p>
<p>This download includes additional data sets for advanced, selective disambiguation.</p>
<p>For details, see "Mark-Christoph Müller, Florian Reitz, and Nicolas Roy (2017): Data Sets for Author Name Disambiguation: An Empirical Analysis and a New Resource", Scientometrics, doi:10.1007/s11192-017-2363-5.</p>
<p> </p
- …
