1,720,978 research outputs found
The Future of Cancer Diagnosis and Treatment: Unlocking the Power of Biomarkers and Personalized Molecular-Targeted Therapies
No full textCancer remains a leading global health challenge, with conventional diagnostic and treatment methods often lacking precision and adaptability. This review explores transformative advancements that are reshaping oncology by addressing these limitations. It begins with an overview of cancer’s complexity, emphasizing the shortcomings of conventional tools such as imaging and chemotherapy, which frequently fail to deliver targeted care. The discussion then shifts to biomarkers, which represent a groundbreaking frontier in early detection, enabling the identification of unique biological signatures that signal the presence of cancer with heightened sensitivity. Building on this foundation, the review examines personalized molecular therapies, which target the specific genetic and molecular vulnerabilities of tumors. These therapies not only enhance treatment efficacy but also minimize adverse effects, offering patients improved outcomes and quality of life. By integrating biomarker-driven diagnostics with tailored therapeutic strategies, a new paradigm of precision oncology emerges, bridging the gap between early detection and effective intervention. Real-world case studies highlight both successes, such as significantly improved survival rates, and persistent challenges, including accessibility and cost barriers. Looking ahead, the review outlines pathways by which to scale these innovations, emphasizing the critical need for robust infrastructure, sustained research investment, and equitable healthcare policies. It concludes by envisioning a future where biomarkers and personalized therapies converge to redefine cancer care, offering earlier detection, precise interventions, and better patient experiences. This work underscores the urgency of adopting cutting-edge approaches to overcome cancer’s persistent threats, paving the way for a more effective and humane era in oncology
Study on Major Reproductive Health Problems in Indigenous and Cross Breed Cows in and Around Bedelle, South West Ethiopia
No full textRevolutionizing Personalized Medicine: Synergy with Multi-Omics Data Generation, Main Hurdles, and Future Perspectives
No full textThe field of personalized medicine is undergoing a transformative shift through the integration of multi-omics data, which mainly encompasses genomics, transcriptomics, proteomics, and metabolomics. This synergy allows for a comprehensive understanding of individual health by analyzing genetic, molecular, and biochemical profiles. The generation and integration of multi-omics data enable more precise and tailored therapeutic strategies, improving the efficacy of treatments and reducing adverse effects. However, several challenges hinder the full realization of personalized medicine. Key hurdles include the complexity of data integration across different omics layers, the need for advanced computational tools, and the high cost of comprehensive data generation. Additionally, issues related to data privacy, standardization, and the need for robust validation in diverse populations remain significant obstacles. Looking ahead, the future of personalized medicine promises advancements in technology and methodologies that will address these challenges. Emerging innovations in data analytics, machine learning, and high-throughput sequencing are expected to enhance the integration of multi-omics data, making personalized medicine more accessible and effective. Collaborative efforts among researchers, clinicians, and industry stakeholders are crucial to overcoming these hurdles and fully harnessing the potential of multi-omics for individualized healthcare
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Serological survey of African horse sickness in selected districts of Jimma zone, Southwestern Ethiopia
No full textA cross-sectional serological survey was undertaken in selected districts of different agro-ecology of
Jimma zone (Dedo, Yebu, Seka, Serbo, and Jimma town)
from November 2009 to February 2010 to determine the
seroprevalence of African horse sickness virus and associated risk factors of the disease. Two hundred seventy-four
equids (189 horses, 43 mules, and 47 donkeys) with a
history of non-vaccination for at least 2 years were selected
randomly from the above areas. Sera samples were
collected and assayed for the presence of specific antibody
against African horse sickness virus using blocking
ELISA. An overall seroprevalence of 89 (32.5%) was
found and it was 24 (51.1%) for donkeys, 13 (30.2%) for
mules, and 52(28.3%) for horses. Seroprevalence was
significantly (X2
=11.05, P<0.05) different among the
different species of equids. Seroprevalence was also
significantly (X2
=11.43, P<0.05) different among the
different agro-ecological areas being higher in highlands
47 (40.5%) followed by midland 30 (34.5%) and lowland
12 (16.9%). Age and sex were not significantly (X2
=3.15,
P>0.05 and X2
=3.38, P>0.05, respectively) associated
with seroprevalence of AHSV. The present study showed
that African horse sickness (AHS) is highly prevalent
disease for the horses followed by mules and then donkeys
in Jimma zone explained by lower seroconversion rate.
Therefore, control strategy against AHS should target at
high risk species of all age and sex in their locality in the
initial stage for better containment of the disease
Prevalence of bovine trypanosomosis in selected areas of Jabi Tehenan district, West Gojam of Amhara regional state, Northwestern Ethiopia
No full textCross sectional study was conducted in Jabi Tehenan district of West Gojjam administrative zone from
October 2008 to April 2009 to determine the current prevalence rate of bovine trypanosomosis. In the
parasitological survey, blood samples of 300 cattle were examined using a buffy coat technique. The
PCV value of each animal was also measured using hematocrit reader. The overall prevalence of
trypanosomosis was found to be 11.7% and it consists of 16, 10 and 9% in Regeb Kebero Meda,
Weyenema Workema and around Finote Selam peasant associations respectively. The most positive
cases were due to Trypanosoma congolense (54.3%) followed by Trypanosoma vivax (45.7%). The mean
PCV value (%) of parasitaemic and aparasitaemic animals during the study period were 20.3±4.1 SD and
25.29±4.67 SD with a significance difference (p < 0.05). The study also demonstrated variations
prevalent among different age groups and between both sexes which were statistically insignificant (p >
0.05). Infection rate in poor body condition animals were significantly higher than good body condition
animals (p < 0.05). The present prevalent study generated valuable information on the epidemiology of
bovine trypanosomosis in the study area and revealed that trypanosomosis is an important disease in
the study are
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