346 research outputs found
Genetic Testing in Periodontitis: A Narrative Review on Current Applications, Limitations, and Future Perspectives
No full textBackground: Periodontitis is a multifactorial inflammatory disease with a complex interplay
between microbial, environmental, and host-related factors. Among host factors, genetic
susceptibility plays a significant role in influencing both disease onset and progression.
Over the past two decades, a wide range of genetic tests, ranging from single-nucleotide
polymorphism (SNP) analysis to genome-wide association studies (GWAS), have been
explored to assess individual risk profiles and potential treatment responses. However,
despite initial enthusiasm, the clinical integration of genetic testing in periodontics remains
limited. This narrative review aims to critically examine the current landscape of genetic
testing in periodontitis, including commercially available tests, their scientific validity, and
their clinical utility. Methods: Most relevant studies which were published in recent years
were identified by using the major scientific search engines, including PubMed, Scopus, and
Web of Science. Articles discussing genetic susceptibility, key gene polymorphisms, and
emerging technologies were included in this narrative review. Results: Polymorphisms in
genes coding for IL-1, IL-6, TNF-α, and in others involved in immune modulation and bone
metabolism, are associated with periodontitis. Nevertheless, there are limitations related
to heterogeneity in study design, population stratification, and gene–environment interactions.
Moreover, emerging technologies, including polygenic risk scoring and machine
learning approaches, may enhance the predictive value of genetic tools in periodontology.
Conclusions: A deeper understanding of genetic susceptibility could pave the way for
precision dentistry and personalized periodontal care, but significant hurdles remain before
genetic testing can become a routine component of periodontal diagnostics
Syndromic and Non-Syndromic Primary Failure of Tooth Eruption: A Genetic Overview
No full textPrimary failure of tooth eruption (PFE) is a rare genetic disorder characterized by the failure of teeth to erupt in the absence of obvious physical obstructions, often resulting in a progressive open bite that is resistant to orthodontic treatment. While PFE can
be caused by genetic or systemic factors (such as cysts, tumors, and endocrine imbalances), the non-syndromic causes are primarily genetic, with an autosomal dominant inheritance pattern with variable expressivity. Several genes have been closely associated
with the non-syndromic PFE form. The PTH1R (parathyroid hormone 1 receptor) is the
most commonly PFE-associated gene. Additional genes associated with minor frequency
are Transmembrane protein 119 (TMEM119), which reduces the glycolytic efficiency of
bone cells, limiting their mineralization capacity and causing bone fragility; Periostin
(POSTN), which regulates the extracellular matrix and the bone’s response to mechanical
stress; and Lysine (K)-specific methyltransferase 2C (KMT2C), which establishes histone
methylation near the Wnt Family Member 5A (WNT5A) gene involved in dental development (odontogenesis). Syndromic forms of PFE are typically associated with complex multisystem disorders, where dental eruption failure is one of the clinical features of the
spectrum. These syndromes are often linked to genetic variants that affect ectodermal development, craniofacial patterning, and skeletal growth, leading to abnormal tooth development and eruption patterns. Notable syndromes include GAPO syndrome, ectodermal dysplasia, and cleidocranial dysplasia, each contributing to PFE through distinct molecular mechanisms, such as disruptions in dental structure development, cranial abnormalities, or systemic developmental delays. The main aim of this review is to provide a comprehensive overview of the genetic basis underlying both syndromic and non-syndromic
forms of PFE to facilitate precision diagnosis, foster the development of personalized therapeutic strategies, and offer new insights into managing this complex dental anomal
Dataset supporting the University of Southampton Doctoral thesis "Self-states, attachment and dissociation: relationships and measurement".
No full textDataset supporting the University of Southampton Doctoral thesis "Self-states, attachment and dissociation: relationships and measurement" by Clarissa Lord.
This data includes an excel file of collected data created by the author as part of their research. </span
Richardson, Barbauld, and the construction of an early modern fan club
No full textMPhilMuch has been written about the life and long works of the eighteenth century epistolary novelist, Samuel Richardson, but the prospect of his position as the first celebrity novelist – responsible for courting his own fame as well as initiating his own fan club – has largely been ignored. The body of manuscripts housed at the National Art Library in the Victoria and Albert Museum in London provides the modern scholar with evidence of the skeletal beginnings of an early fan club. This thesis aims to show how these manuscripts were turned into a saleable commodity by the publisher and entrepreneur Richard Phillips, while under the guiding hand of another, slightly later, literary celebrity, Anna Laetitia Barbauld. In order to restore Richardson’s reputation amongst a new nineteenth century audience, Barbauld was required to construct her own idea of him as an eighteenth century celebrity author, and in doing so the insecurities of a self-professed, apparently diffident man, are revealed. Barbauld’s capacious, but heavily edited selection of letters is analyzed in this thesis, providing ample evidence that Richardson’s correspondents were more than just eager letter writers. By using Barbauld’s biography of Richardson this thesis aims to show how she manipulates the genre of life writing in her construction of him.
This thesis offers an alternative reading of how the Richardson manuscripts are viewed, redefining them as not simply a collection of letters, but as a collective entity, deliberately selected and archived as evidence of an early modern fan club, and its celebrity managing director
Genetic Aspects of Tooth Agenesis
No full textTooth agenesis is among the most prevalent congenital anomalies affecting human
dentition, characterized by the developmental absence of one or more teeth. This condition
may be present in either syndromic or non-syndromic forms, with significant implications
for oral function, aesthetics, and craniofacial development. This narrative review aims to
provide a comprehensive overview of tooth agenesis, defining its classification, genetic
underpinnings, epidemiological aspects, phenotypic features, and therapeutic approaches.
Recent advances in genetic research have identified numerous causative genes, notably
EDA, MSX1, WNT10A, and PAX9, each associated with specific patterns of missing teeth
and involved in isolated and/or syndromic forms. Additionally, genes such as TSPEAR,
LRP6, PITX2, and GREM2 contribute to varying degrees of severity and tooth distribution,
often blurring the lines between syndromic and isolated cases. The genotype-phenotype
correlations underscore the complexity of the underlying molecular pathways involved in
odontogenesis. From a therapeutic perspective, the management of tooth agenesis requires
a multidisciplinary approach, often involving orthodontic, prosthetic, and surgical interventions tailored to the severity of tooth loss and patient age. Early diagnosis represents
a crucial role in treatment planning, facilitating timely intervention during growth and
enhancing long-term outcomes. In conclusion, tooth agenesis remains a complex clinical
condition with a strong genetic basis. A patient-centered and interdisciplinary strategy is
essential to address both functional and psychosocial needs
The History Behind "Surviving Sarasota"
No full textAuthor Clarissa Thomasson discusses the history of Sarasota County, which she based her fiction novel "Surviving Sarasota" on
Clarissa against the critics: Text, author, and interpretive communities
No full textClarissa was very popular when it was published in 1747-48 but has been neglected until recently. Stanley Fish\u27s theory of interpretive communities, which attempts to account for the disciplined disagreement among readers\u27 values and expectations over time, place, and social groups, provides insight into the dynamics of the audience\u27s changing attitude toward the novel over the years. Popular, at first, for its sentiment and didacticism, Clarissa was neglected from the late-eighteenth century until the mid-twentieth century because these qualities were then associated with emotionalism and hypocrisy. The novel has had a rebirth of popularity among contemporary academics who use its complex and detailed descriptions of relationships and mental consciousness as examples for their literary and cultural studies
A Fine Toothed Comb
No full textThe publication includes: essays by Lubaina Himid, Lauren Elkin, author of Art Monsters: Unruly Bodies in Feminist Art, Flaneuse: Women Walk the City in Paris, New York, Tokyo, Venice and London, and Clarissa Corfe.
Edited by Beth Hughes. Designed by Pony Ltd, London.
A Fine Toothed Comb was an exhibition curated by Turner Prize-winning artist Lubaina Himid. Bringing together new commissions by Himid as well as artists Magda Stawarska, Rebecca Chesney and Tracy Hill, the exhibition focussed on unearthing hidden layers within the city of Manchester.
Through four unique installations spanning painting on found objects, multi-screen moving image, site-specific drawing and sound compositions, the artists’ work uncovered invisible geological, historical, environmental and political layers of the city. From hidden waterways and disappearing wildlife, to lost music and communities hidden in plain sight, A Fine Toothed Comb invited us to look closer at what surrounds us. This is the first time all four artists’ work was presented together, following many years of discussion and collaboration.
The publication includes: essays by Lubaina Himid, Lauren Elkin, author of Art Monsters: Unruly Bodies in Feminist Art, Flaneuse: Women Walk the City in Paris, New York, Tokyo, Venice and London, and Clarissa Corfe
The Power...to Alter and Amend : Textual Production and Editorial Actions in Samuel Richardson\u27s Clarissa .
No full textThis dissertation is a study of texts, focusing on how texts are constructed (through both words as well as physical attributes) and how they are edited after their initial composition. The scope of this dissertation is limited to Samuel Richardson (1689-1761) and his rare 1750 third edition of Clarissa and to the characters in Clarissa and their familiar letters. I argue that the altering of a text is a negotiation of power between the editor and the author, and that editors advance their personal agendas by undermining the intentions of the author. In Chapter 1, I explain the relevancy of textual studies to literary criticism. In Chapter 2, I examine how Richardson, master printer as well as author, constructs Clarissa as a material text, meaning that he builds plot, characterization, and his didactic message through the text\u27s linguistic as well as physical features. In Chapter 3, I address the familiar letters constructed by characters within Clarissa. Although the material details of these fictional letters--including handwriting and seals--cannot be seen by readers of the novel, they can still be conceptualized in the mind and interpreted for their visual meaning. In Chapter 4, as a transition to the editing of texts, I summarize the eighteenth- and twentieth-century editorial theories most relevant to Clarissa. In Chapter 5, I evaluate Richardson\u27s role as editor of Clarissa, focusing on the textual apparatus he constructs around his novel. Richardson exploits the editorial role in a manner not seen in other eighteenth-century novels, using the apparatus to control readers\u27 interpretations. In Chapter 6, I discuss the characters in Clarissa as editors, showing how they frequently alter and even forge/rewrite letters after their initial composition. These editorial actions, which I refer to as fictional editing, expand the narrative beyond the initial act of writing and complicate the issues of characterization, gender, and subjectivity inherent in the familiar letter. In Chapter 7, I conclude by suggesting additional concerns for textual/literary critics, including the implications of lost physical details in electronic texts
Poetics and economy of communication in Samuel Richardson's Clarissa
No full textLe problème de la communication, et pas seulement du danger des liaisons, est au cœur du roman épistolaire de manière générale et de Clarissa de Samuel Richardson en particulier. Sans cesse menacée d'interruption, la communication représentée dans la diégèse du deuxième roman de Richardson influe également sur le sens et relève à ce titre de ce que Janet Altman a appelé l'épistolarité. Cette étude se concentre sur le code de la communication représentée dans l'œuvre et saisit la lettre dans l’économie de l’information toute particulière dont elle participe, à la croisée d'une communication interne entre ses personnages et des exigences d'une communication externe qui voit le matériau épistolaire affluer vers le Lecteur. Elle s'efforce de souligner à quel point le scénario romanesque est informé par la nature des communications au travers desquelles il s’exprime ainsi qu'à travers les communications auxquelles il donne lieu (Clarissa étant l'objet d'âpres négociations entre son auteur et ses lecteurs), tout comme il informe à son tour la nature de ces communications. L'examen de la communication dans et autour du roman de Richardson met en évidence l'existence d'une poétique qui est aussi une économie. L'histoire de Clarissa n'est pas tant l'histoire de ses lettres que celle de ses communications.The problem of communication, and not only that of the danger of the liaisons, is at the heart of the epistolary novel in general and of Samuel Richardson's Clarissa in particular. Constantly threatened with interruption, the communication represented in the diegesis of Richardson's second novel also informs meaning and thus belongs to what Janet Altman called epistolarity. This study concentrates on the code of communication represented in the work and endeavors to grasp the letter in its particular economy of communication, at the crossroads of internal communication between its characters and the demands of an external communication that requires that the epistolary material be oriented towards the reader. This study strives to underline to what extent the novelistic scenario is informed by the nature of the communications through which it expresses itself as well as by the communications it produces among its readers in the shape of letters to the author. The examination of communication in and around Richardson's novel bears witness to the existence of a poetics that is also an economy. The history of Clarissa is not so much that of its letters as that of its communications
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