601 research outputs found
Dentigerous Cyst
No full textDentigerous Cyst
Dental School Radiology Presentation : Dentigerous Cyst
Author : Tadinada, Aditya
Medical Subject : Dentigerous Cyst, Odontogenic Cysts
Clinical Presentation Description : Radiolucency arising from the CEJ of an unerupted tooth
Location of Abnormality : Posterior Mandible
Radiological Features : Radiolucency arising from the CEJ of an unerupted tooth
DDx Description : Dentigerous cyst, odontogenic keratocyst, ameloblastoma
Type of Image : Panoramic Radiograph
Digital Publisher : UCONN Health Center : Kilham, Jessica
Format : jpg
Date : 201
Induced pluripotent stem cell based modeling of gastrointestinal disease using human intestinal organoids
No full textThe human gastrointestinal (GI) epithelium performs major physiologic functions that are critical to survival, health, and homeostatic equilibrium. While model organisms and in vitro cell culture systems have been widely used to study both normal and disease states of the GI tract, these often fail to fully recapitulate critical features of in vivo intestinal tissue. In recent years, investigators have harnessed the ability to perform directed differentiation of human induced pluripotent stem cells (iPSCs) towards cell types originating from all three embryonic germ layers, most notably a wide variety of endodermal lineages, in an attempt to generate in vitro models that better recapitulate human physiology and key developmental milestones. These iPSC-derived cells contain the exact genetic background of a particular donor or patient and are easily amenable to gene-editing, making them particularly advantageous in comparison to non-human model organisms or in vitro cell culture systems often derived from malignant tissue. Here, we report the efficient generation of iPSC-derived mesenchyme-free human intestinal organoids (HIOs) that can be primed towards colonic or proximal intestinal lineages in serum-free defined conditions. By generating a novel CDX2-eGFP iPSC knock-in reporter line to track the emergence of hindgut progenitors, we follow the kinetics of CDX2 expression throughout directed differentiation, enabling the purification of intestinal progenitors. We employ these mesenchyme free HIOs to highlight cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction using cystic fibrosis (CF) patient-derived iPSC lines before and after correction of the CFTR mutation. We also demonstrate that these HIOs represent a powerful tool to model pathogen-mediated GI illness, characterizing the intestinal epithelial host response to infection by the coronavirus SARS-CoV-2 as well as two filoviruses, Ebola (EBOV) and Marburg (MARV). Finally, we report the generation of a clinically relevant library of iPSCs derived from patients with Crohn’s Disease (CD), including successful directed differentiation of these lines to a relevant immune cell type, as a proof of concept for their use in CD in vitro modeling. Taken together, our results provide a comprehensive and reductive iPSC-based model to study disease states of the intestinal epithelium, ranging from enteric viral infection to mendelian disorders such as CF and autoimmune conditions such as inflammatory bowel disease (IBD), highlighting the potential of organoids as a powerful tool for disease modeling and therapeutics development
Design, modeling and real-time monitoring of continuous powder mixing processes
No full textContinuous processing is an advantageous alternative for the current methods used in the pharmaceutical manufacturing. Important advantages that it offers include smaller equipment footprint, reduced efforts in the scale-up work, and the potential to utilize already continuous processes to make the entire manufacturing more efficient. In the current pharmaceutical manufacturing environment, powder mixing process is carried out in the batch mode. The necessary methods and guidelines to design an equivalent continuous process are not well established. The work presented in this dissertation focuses on the characterization, design and optimization of a continuous powder mixing process for pharmaceutical powders. A systematic study was performed of the effects of process and design variables, and material properties involved in the continuous powder mixing process. The bulk powder flow behavior was characterized using the residence time distribution (RTD) measurement approach. Impeller speed, material bulk density and impeller design greatly influenced the mean residence time. With increasing impeller speed, mechanical fluidization was observed, which significantly affected axial dispersion coefficients. Intermediate rotation rates exerted maximum strain on the material, which leads to maximum homogenization. The strain measurements correlated well with the properties of tablets including content uniformity and tablet hardness. Mixing performance was largely dominated by the material properties of the mixture, and the blend uniformity measurement was affected by the sample size analyzed. An experimental protocol was developed to measure the blend uniformity in the in-line mode, and a methodology was further built to quantitatively relate the in-line NIR measurements with the off-line wet chemistry measurements. Considering the shear limitations of the continuous bladed mixer, alternative blending strategies, suitable for blending of cohesive materials were also demonstrated. A combination of a high-shear mixing followed by a low-shear mixing process provided the optimal mixing performance. The predictive understanding of the continuous powder mixing process developed in this dissertation can assist towards the design and development of a fully controlled continuous manufacturing process.Ph. D.Includes bibliographical referencesIncludes vitaby Aditya U. Vanaras
Crystal Dynamics and Anharmonic Properties of Bi-Pb-Tl Alloys
No full textTitle: Crystal Dynamics and Anharmonic Properties of Bi-Pb-Tl Alloys, Author: Aditya P. Roy, Location: ThodeThe crystal dynamics and anharmonic properties have
been investigated in disordered alloys of Bi-Pb-Tl using slow
neutron spectrometry. Damping of phonons caused by phonon-phonon
interaction and the effect of the force constant
disorder on the lifetime of the phonons have been studied in
the alloys. Measurements of the coefficients of thermal
expansion are reported. An experimental method of determining
the lattice frequency spectra by coherent inelastic scattering
of neutrons from polycrystalline materials is described.ThesisDoctor of Philosophy (PhD
On the two-potential constitutive modelling of rubber viscoelastic materials
No full textU of I Only Restriction Lifted for Item 93166 on 2018-07-08T09:15:36Z."This work lays out the specialization of the two-potential constitutive framework --- also known as the ""generalized standard materials'' framework --- to rubber viscoelasticity. Inter alia, it is shown that a number of popular rubber viscoelasticity formulations, introduced over the years following different approaches, are special cases of this framework. As a first application of practical relevance, the framework is utilized to put forth a new objective and thermodynamically consistent rubber viscoelastic model for incompressible isotropic elastomers. The model accounts for the non-Gaussian elasticity of elastomers, as well as for the deformation-enhanced shear thinning of their viscous dissipation governed by reptation dynamics. The descriptive and predictive capabilities of the model are illustrated via comparisons with experimental data available from the literature for two commercially significant elastomers."Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-05-01The student, Aditya Kumar, accepted the attached license on 2016-04-21 at 16:42.The student, Aditya Kumar, submitted this Thesis for approval on 2016-04-21 at 17:40.This Thesis was approved for publication on 2016-04-25 at 13:53.DSpace SAF Submission Ingestion Package generated from Vireo submission #9421 on 2016-07-07 at 13:50:34Made available in DSpace on 2016-07-07T20:27:55Z (GMT). No. of bitstreams: 2
KUMAR-THESIS-2016.pdf: 837141 bytes, checksum: 4cd6a13625dabb966b6db0afa249edcc (MD5)
LICENSE.txt: 4209 bytes, checksum: 0e09e0cd09aa5811ed8246d9f3eb6e6d (MD5)
Previous issue date: 2016-04-25Embargo set by: Seth Robbins for item 93166
Lift date: 2018-07-07T20:28:14Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 93166
Lift date: 2018-07-07T20:35:34Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD syste
Stitches: Blending landscape fabric through the golden threads of spatial identity in San Riku coastline, Otsuchi, Iwate, Japan
No full textDisaster prevention and coastal protection of Otsuchi have affected the livelihood and the daily pattern of lifestyle of the regular Otsuchian. This work represents the alternative to a typical top down prefectural level demand for a line based infrastructural solution to disaster prevention and creates the required importance of livelihood, culture and identity of a place over the protection structure. While in the design of such critical areas it is important to place protection of the citizens at a high level, it is also a necessity to understand the situation of each city as different from each other. In this way, the genius loci of a place is founded. Along the San Riku coastline where the tsunami and earthquake hit the hardest due to the landscape features and the proximity to the epicenter the government has set a list of top down governed structures that have impacted the urban fabric of the city, This document looks at one of these towns “Otsuchi” and how alternate solutions based on the historical and landscape features of the district can help create landscapes of livelihood for the citizens. Otsuchi among many other Japanese cities faces the issue of a shrinking population due to a lack of economy, a lack of education in the rural areas and a lack of opportunities. The design document also looks at how Identity crisis in a Rias coastline/ Aditya Athreya Rao/ TU Delft 1 landscape can create a set of cyclical opportunities for the people to develop their town responsibly and sustain-ably as they see fit. Landscape design seeks to provide opportunity to the stakeholders to further create, it provides the platform for this creation and the thesis looks at ideas and solutions on ways this can be done. Keywords: Landscape Infrastructure, Identity, Contextual Design Genius Loci, Landscape Design, New landscapesFlowscapesArchitecture, Urbanism and Building Sciences | Landscape Architectur
Navigating the Second Victim Experience in Gastrointestinal Endoscopy and Colonoscopy.
No full textThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,
provided the original work is properly cited.
© 2025 The Author(s). JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and
John Wiley & Sons Australia, Ltd
Evaluating model free policy optimization strategies for non linear systems
No full textThe Iterative Linear Quadratic Regulator (ILQR), a variant of Differential Dynamic Programming (DDP) is a tool for optimizing both open-loop trajectories and guiding feedback controllers using dynamics information that can be inferred from data. This technique assumes linear dynamics and quadratic cost functions and improves the control policy iteratively until convergence. We demonstrate the capabilities of this framework in designing controllers for regulating both natural and custom behavior on a simple pendulum, the primitive non linear system. The method's assumptions limit its validity to smaller regions of the state space. Direct Policy Search methods use Reinforcement Learning to develop controllers for such scenarios. Nevertheless, these methods require numerous samples to generate an optimal policy and often converge to poor local optima. Guided Policy Search (GPS) is a new technique that optimizes complex non-linear policies, such as those represented through deep neural networks, without computing policy gradients in high dimensional parameter space. It trains the policy in a "supervised" fashion using numerous locally valid controllers produced by ILQR. GPS provides appealing improvement and convergence guarantees in simple convex and linear settings and bounds the error in a non-linear setting. We apply Guided Policy Search to generate control policies for locomotion of a tensegrity robot, producing closed-loop motion that could not be achieved with previous methods.M.S.Includes bibliographical referencesby Aditya H. Chukk
Web based process mining and visualization tool
No full textProcess mining has received huge attention by researchers in the last couple of decades. Business processes leave execution logs in various forms which can be examined and analyzed to formalize the process execution. Process mining techniques help analysts to extract knowledge from event logs and traces. Due to ever increasing amount of data and need of mobility and platform independence it is becoming harder to provide a visualization for analysis without overwhelming the user. Informal processes leave behind event logs that cannot be analyzed by plain old algorithms. The information and properties regarding a process highly depends upon the domain and hence a variety of conformance models needs to be analyzed. The existing process mining and visualization tools (Prom, EventFlow, RapidMiner) provide sophisticated visualization at the cost of mobility and platform independence. Therefore, in this thesis we propose a web based mobile and platform independent approach extending Trace Alignment [1][2] based approach to provide a feasible solution to the problem.M.S.Includes bibliographical referencesby Aditya Shukl
Aktivitet: Author of Book Chapter on "Asset Performance Measurement"
No full textAuthor of Book Chapter on "Asset Performance Measurement" in Asset Management- The state of the art in Europe, published by Springer</p
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