186,382 research outputs found
Performance improvement of pulse width-amplitude modulation-based quasi-Z-source inverters: Analysis and implementation
No full textPulse width-amplitude modulation (PWAM) have been widely used in recent years to mitigate switching losses as well as reducing passive components' size. This paper precisely investigates this modulation approach in quasi-Z-source inverters (qZSI). It will be concluded that the existence of capacitive paths from load to source in such converters causes two undesired behaviors while utilizing PWAM, which increases total harmonic distortion and semiconductor stresses. Bypassing the capacitive paths is proposed in this paper to alleviate these issues. In order to implement this approach, a bidirectional quasi-Z-source inverter is studied. A design procedure is presented to achieve a fast dynamic response for tracking reference voltage. The operation of both conventional and bidirectional qZSI under different loads including resistive and resistive–inductive loads is investigated in the simulation and experiment. According to experimental results, by utilizing bidirectional qZSI, THD is improved from 12.34% to 3.51% for a lag load. Moreover, the voltage stress of the semiconductor no longer exists
Estimate US counties woody biomass availability and transportation cost
No full textBash and Python scripts to collect US counties biomass data from FIA database and computing cost of transportation from counties’ centroid to other counties and coal burning power plants.Repository:https://gitlab.com/ashki23/rc-county-biomass Publication:Picciano P, Aguilar FX, Burtraw D, Mirzaee A. Environmental and Socio-Economic Implications of Woody Biomass Co-firing at Coal-Fired Power Plants. Resource and Energy Economics. 2022 Feb 8:101296. https://doi.org/10.1016/j.reseneeco.2022.101296 </div
The role of 5'-nucleotidases and deoxynucleoside kinases in responses to nucleoside analogues
No full textThe efficacy of nucleoside analogues (NAs) in treating several hematological malignancies, solid tumors and viral infections is limited primarily by side-effects and the development of drug resistance. The aims of the present thesis were to elucidate mechanism(s) involved in tissue-specific toxicity associated with NA therapy, as well as the mechanisms underlying resistance to these drugs.The mRNA levels and activities of different cytosolic and mitochondrial deoxynucleoside kinases (dNKs) and 5'-nucleotidases (5'- NTs) exhibit a distinct pattern for each of a variety of mouse tissues. Heart and skeletal muscle, as well as adipose tissue demonstrate low levels of both the anabolic and catabolic enzymes, which may explain at least some of the adverse side-effects of NA treatment.A novel approach based on high-performance liquid chromatography (HPLC) revealed that each of 14 different mouse and rat tissues exhibits a unique profile of dNK and 5'NT activities, with 2-3-fold species differences for certain of these tissues. These observations have important implications for the choice of an animal model for characterization of NA toxicity.The cytotoxicity of gemcitabine (a cytidine-containing NA employed clinically to treat patients with cancer) towards human leukemia and melanoma cell lines rendered deficient in either deoxycytidine kinase (dCK) or deoxyguanosine kinase (dGK) with siRNA was compared to the corresponding toxicity towards cells that express these enzymes. Both types of deficient cells were more sensitive to gemcitabine, suggesting that, at least in this system, the toxicity of this drug is not correlated to the levels of activating enzymes.The activites of various 5'-NTs in peripheral blood cells isolated from CLL patients show considreble inter-individual variation. Degradation of the phosphorylated forms of cladribine and fludarabine, two important anti-leukemic NAs, was characterized in these cells. Significant correlations between the rate of cladribine monophosphate degradation and the activity of cytosolic 5'-nucleotidase 1 (CN1), as well as between the rate of fludarabine monophosphate degradation and the activity of cytosolic 5'-nucleotidase 2 (CN2) were observed.This investigation provides new insights regarding the patterns of expression of anabolic and catabolic enzymes that hopefully can be used to improve NA therapy in the future.List of scientific papersI. Rylova SN, Mirzaee S, Albertioni F, Eriksson S (2007). "Expression of deoxynucleoside kinases and 5-nucleotidases in mouse tissues: implications for mitochondrial toxicity." Biochem Pharmacol 74(1): 169-75. Epub 2007 Apr 12 https://pubmed.ncbi.nlm.nih.gov/17493587II. Mirzaee S, Eriksson S, Albertioni F (2010). "Differences in cytosolic and mitochondrial 5-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: implication for the toxicity of nucleoside analogs in animal models." Toxicology 267(1-3): 159-64. Epub 2009 Nov 12 https://pubmed.ncbi.nlm.nih.gov/19913594III. Fyrberg A, Mirzaee S, Albertioni F, Lotfi K (2010). "RNA interference targeting nucleoside analog activating enzymes in leukemic and solid malignancies enhances the effect of gemcitabine." (Submitted)IV. Mirzaee S, Wang X, Bayat N, Fyrberg, Lotfi K, Karlsson K, Juliusson G, Eriksson S (2010). "Freidoun Albertioni. Activity profiles of 5-nucleotidases in blood cells from untreated patients with B-cell chronic lymphocytic leukemia and in phytohemag-glutinin stimulated cells from healthy subjects: correlation to nucleoside analogues therapy." (Manuscript)</p
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Amino-silane co-functionalized h-BN nanofibers with anti-corrosive function for epoxy coating
No full textIn this research, hexagonal boron nitride nanofibers co-functionalized with polydopamine and (3-aminopropyl) triethoxysilane (Fh-BNNFs) are used for developing anti-corrosion solvent-based nanocomposite epoxy coatings. The h-BNNFs are successfully synthesized by utilizing inexpensive precursors of melamine and boric acid. The prepared nanomaterials are characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, thermal gravimetric analysis, field emission scanning electron microscopy, and N2 adsorption/desorption isotherms. The corrosion resistance of the pure and nanocomposite epoxy coatings is investigated by electrochemical impedance spectroscopy, Potentiodynamic polarization tests, salt spray, and pull-off adhesion measurements. The results indicate that the epoxy nanocomposite coatings containing optimum amount of the Fh-BNNFs show superior corrosion resistance. Moreover, density functional theory (DFT) method is applied to investigate the energetics and interaction mechanisms at each interface within the epoxy matrix
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Edward P. Wimberly, ITC, July 2011
No full textThis video is a conversation with Dr. Edward P. Wimberly. Dr. Wimberly talks about his book, "No Shame in Wesley's Gospel: A Twenty-First Century Pastoral Gospel". Brad Ost, AUC Woodruff Library, is the interviewer
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