1,721,027 research outputs found
Supplementary_File_1 – Supplemental material for The cluster randomized crossover trial: The effects of attrition in the AB/BA design and how to account for it in sample size calculations
No full textSupplemental material, Supplementary_File_1 for The cluster randomized crossover trial: The effects of attrition in the AB/BA design and how to account for it in sample size calculations by Mirjam Moerbeek in Clinical Trials</p
Supplementary_File_2 – Supplemental material for The cluster randomized crossover trial: The effects of attrition in the AB/BA design and how to account for it in sample size calculations
No full textSupplemental material, Supplementary_File_2 for The cluster randomized crossover trial: The effects of attrition in the AB/BA design and how to account for it in sample size calculations by Mirjam Moerbeek in Clinical Trials</p
sj-docx-1-smm-10.1177_09622802211037066 - Supplemental material for Optimal allocation to treatments in a sequential multiple assignment randomized trial
No full textSupplemental material, sj-docx-1-smm-10.1177_09622802211037066 for Optimal allocation to treatments in a sequential multiple assignment randomized trial by Andrea Morciano and Mirjam Moerbeek in Statistical Methods in Medical Research</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Optimal allocation of clusters in stepped wedge designs with a decaying correlation structure
No full textThe cluster randomized stepped wedge design is a multi-period uni-directional switch design in which all clusters start in the control condition and at the beginning of each new period a random sample of clusters crosses over to the intervention condition. Such designs often use uniform allocation, with an equal number of clusters at each treatment switch. However, the uniform allocation is not necessarily the most efficient. This study derives the optimal allocation of clusters to treatment sequences in the cluster randomized stepped wedge design, for both cohort and cross-sectional designs. The correlation structure is exponential decay, meaning the correlation decreases with the time lag between two measurements. The optimal allocation is shown to depend on the intraclass correlation coefficient, the number of subjects per cluster-period and the cluster and (in the case of a cohort design) individual autocorrelation coefficients. For small to medium values of these autocorrelations those sequences that have their treatment switch earlier or later in the study are allocated a larger proportion of clusters than those clusters that have their treatment switch halfway the study. When the autocorrelation coefficients increase, the clusters become more equally distributed across the treatment sequences. For the cohort design, the optimal allocation is almost equal to the uniform allocation when both autocorrelations approach the value 1. For almost all scenarios that were studied, the efficiency of the uniform allocation is 0.8 or higher. R code to derive the optimal allocation is available online
Optimal placebo-treatment comparisons in trials with an incomplete within-subject design and heterogeneous costs and variances.
No full textThe aim of a clinical trial is to compare placebo to one or more treatments. The within-subject design is known to be more efficient than the between-subject design. However, in some trials that implement a within-subject design it is not possible to evaluate the placebo and all treatments within each subject. The design then becomes an incomplete within-subject design. An important question is how many subjects should be allocated to each combination of placebo and treatments. This paper studies optimal allocations of subjects in trials with a placebo and two treatments under heterogenous costs and variances. Two optimality criteria that consider the placebo-treatment contrasts simultaneously are considered, and the design is derived under a budgetary constraint. More subjects are allocated to those combinations with higher variances and lower costs. The optimal allocation is compared to the uniform allocation, which allocates equal number of subjects to each placebo and treatment combination, and to the complete within-subject design, where placebo and all treatments are available in each subject. The methodology is illustrated on the basis of an example on consultation time in primary care. A Shiny app is available to facilitate use of the methodology
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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