1,720,977 research outputs found

    Attività fisica adattata e dipendenza da alcol: strategie di intervento

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    L'abuso di alcol è un grave problema sociale e il paziente richiede un intervento terapeutico e riabilitativo appropriato. Le persone con patologie alcol-correlate dimostrano frequentemente difficoltà psicomotorie e hanno un basso livello di fitness. La presenza di un adeguato programma di attività motorie appare perciò importante nel progetto riabilitivo di queste patologie, per affrontare aspetti specifici dell'intossicazione alcolica e per educare il paziente alla modificazione del suo stile di vita

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Double-blind, controlled study of tauroursodeoxycholic acid in elderly patients with hepatitis C virus-related cirrhosis.

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    Abstract: To date no effective drug has been available for the treatment of hepatitis C virus (HCV)-related cirrhosis in elderly patients. A randomized, double-blind, placebo-controlled study of tauroursodeoxycholic acid (TUDCA) was conducted in elderly patients with HCV-related cirrhosis. Forty patients (14 men and 26 women; mean age, 70 years; age range, 65 to 79 years) were randomly allocated to receive either TUDCA 500 mg/d or placebo for 6 months. At baseline, the 2 groups were comparable in terms of the frequency of the major clinical symptoms of fatigue and dyspepsia; however, pruritus was significantly more severe in the TUDCA treatment group (P < 0.05). The following assessments were made at baseline and after 3 and 6 months of treatment: a complete clinical examination and determination of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase (GGT), alkaline phosphatase, total cholesterol, triglycerides, fractioned bilirubin, prothrombin time, and serum albumin. Liver ultrasonography was performed at baseline and at the end of treatment. Each clinical symptom was assessed on a 4-point scale, in which 0 = absent, 1 = mild, 2 = moderate, and 3 = severe. During the study period, 7 patients (3 in the TUDCA-treated group and 4 in the placebo group) were withdrawn; 33 patients completed the study. Pruritus decreased significantly in the TUDCA group (0.353) compared with an increase in the placebo group (0.067) (P < 0.05). Dyspepsia and fatigue did not show any statistically significant changes in either group. In the placebo group, transaminases had decreased significantly (P < 0.05) after 3 months; this decrease was maintained at 6 months. In the TUDCA group, a significant reduction in transaminase values was reached at 6 months (P < 0.01). The other biochemical variables did not show any significant change in either group. Results of this study suggest that TUDCA is ineffective in inducing a biochemical remission in HCV-related cirrhosis in the elderly
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