196,897 research outputs found
The mints of Mendoza (Argentina)
No full textSe realiza el relevamiento de las "mentas" espontáneas y cultivadas de la provincia. Se confecciona una clave con las mentas identificadas, a saber: tres especies, Mentha requienii Benth., M. spicata L. y M. aquatica L.; y dos híbridos: M. x piperita L. y M. x rotundifolia (L.) Hudson.An inventory of spontaneus and cultivated mints of Mendoza province is made. A key and a brief description of identificated mints is compounded: three species, Mentha requienii Benth., M. Spicata L. y M. aquatica L.; and two hybrids, M. x piperita L. y M. x rotundifolia (L.) Hudson.Fil: Rouquaud, Elena.
Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Ciencias BiológicasFil: Lúquez Bibiloni, Claudia V..
Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Ciencias Biológica
Mints as Volcanoes: Fire and Technology
No full textthe study of mints as workshops using fire, brings along the association with god Volcano since Antiquity down to the 17th century, with a special documentation for central Italy in the 13th centyry
Introducing Three New Fruit-Scented Mints to Farmlands: Insights on Drug Yield, Essential-Oil Quality, and Antioxidant Properties
No full textMint species are one of the most traded medicinal plants with a wide array of applications in the food, pharmaceutical, and perfumery industries. Here, a field experiment based on completely randomized block design (RCBD) aimed to compare drug yield, antioxidant properties, and essential-oil (EO) quality of three newly introduced mints (i.e., ginger mint, pineapple mint, and grapefruit mint) with a chiefly cultivated one (i.e., peppermint). The results manifested that dry-weight yield and EO yield of grapefruit mint (310 g/m(2) and 5.18 g/m(2), respectively) was approximately 2 times more than that of others. The highest EO content (i.e., 3.12%, v/w)) was obtained from the ginger mint; however, there were no significant differences among the other three mints. The highest total flavonoids content and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity of both methanolic and ethanolic extracts were found in pineapple and grapefruit mint. Methanolic extract of ginger mint yielded the highest total polyphenol content, whereas the ethanolic extract of pineapple mint showed the highest total polyphenol content. According to mean comparisons, the EO of ginger mint exhibited the highest antioxidant activity (EC(50) value = 2.23 µL/mL), while EO of peppermint showed the lowest antioxidant activity (EC(50) value = 48.23 µL/mL). Gas chromatography analysis identified four EO types among these mints: (i) grapefruit mint EO rich in linalool (51.7%) and linalyl acetate (28.38%); (ii) ginger mint EO rich in linalool (59.16%); (iii) pineapple mint EO rich in piperitone oxide (77.65%); and (iv) peppermint EO rich in menthol (35.65%). The findings of the present study provide new insights into the cultivation of preferable mints possessing desired characteristics for food and drug industries
The Coins Pressed In Mints Of Aydinoğullari Beylik
No full textXIV. yüzyılın başlarında Kütahya, Afyon ve Denizli bölgesinde hâkim olan Germiyanoğullannın batıya yaptıkları akınlar sırasında Aydınoğlu Mehmed Bey ve kardeşleri önemli rol oynamışlar, daha sonrasında Ege bölgesinde yaklaşık yüz yirmi yıl hüküm sürerek bölgeye hâkim olmuşlardır (M.1308-1390 / M.1403-1426). Çalışmamız bu dönemde Aydınoğulları tarafından basılan sikkeler üzerindeki darp yerlerini tanıtmayı amaçlamaktadır. Aydınoğlu beylerinden; Mübarizeddin Mehmed Bey, I. Umur Bey, Hızır Bey, İbrahim Bahadır Bey, Süleymanşah, Yakup Bey, İsa Bey, Musa bey, II. Umur Bey, Cüneyd Bey ve Mustafa Bey’e ait sikkelerden örnekler günümüze ulaşabilmiştir247. Sikkeler üzerinde görülen darp yerleri; Ayasuluk, Birgi, Sultanhisar, İzmir, Lâdik, Tire ve Yenişehir’dir. Çalışmamızda Aydınoğulları tarafından bastırılan sikkeler darphane bazında değerlendirilmeye çalışılacaktır.Germiyanogullari dominated in Kütahya, Afyon and Denizli regions in the early part of the XIV. century and Aydinoglu Mehmed Bey and his brothers played an important role during the influxes they made to the west. Afterwards, they dominated in the Aegean region by ruling for about a hundred and twenty years (1308-1390/1403-1426). Our aim is to introduce the mints written on the coins which was minted by Aydinogullari during this period. Coins, which belonged to Mübarizeddin Mehmed Bey, I. Umur Bey, Hızır Bey, İbrahim Bahadır Bey, Süleymanşah, Yakup Bey, İsa Bey, Musa bey, II. Umur Bey, Cüneyd Bey and Mustafa Bey from Aydinogullari have reached the present day. The mints seenon the coins are Ayasuluk, Birgi, Sultanhisar, İzmir, Lâdik, Tire and Yenişehir. In our work, the coins minted by Aydinogullari are evaluated based on their mints
Heterogeneity of three molecular data partition phylogenies of mints related to M. x piperita (Mentha; Lamiaceae)
No full textInternational audiencePhylogenetic reconstructions with molecular tools are now widely used, thanks to advances in IPCIR and sequencing technologies. The choice of the molecular target still remains a problem because too few comparative data are available. This is particularly true for hybrid taxa, where differential introgression of genome parts leads to incongruity between data sets. We have studied the potential of three data partitions to reconstruct the phylogeny of mints related to M. x piperita. These included nuclear DNA (ITS), chloroplast DNA (non-coding regions tmL intron, intergenic spacers trnL-trnF, and psbA-trnH), and AFLIP and ISSR, markers. The taxonomic sampling was composed of hybrids, diploid and polyploid genomes. Since the genealogy of cultivated mint hybrids is known, they represent a model group to compare the usefulness of various molecular markers for phylogeny inference. Incongruities between ITS, chloroplast DNA, and AFLIP-ISSR phylogenetic trees were recorded, although DNA fingerprinting data were congruent with morphological classification. Evidence of chloroplast capture events was obtained for M. x piperita. Direct sequencing of ITS led to biased results because of the existence of pseuclogenes. Sequencing of cloned ITS further failed to provide evidence of the existence of the two parental copy types for M. x piperita, a sterile hybrid that has had no opportunity for concerted evolution of ITS copies. AFLP-ISSIR data clustered M. x piperita with the parent that had the largest genome. This study sheds light on differential of introgression of different genome regions in mint hybrids
Methodological approaches towards personalised cancer medicine
No full textDespite advances in diagnostics and treatments, many cancer patients have poor survival rates. Tumours develop drug resistance followed by metastasis, and survivors suffer from treatment side-effects. Omics techniques, targeted treatments and immunotherapy offer the prospect of individually adapting treatments for optimal efficacy and minimal side-effects. This requires integration of biomolecular, clinical and drug data to successfully predict optimal treatments for every patient. The aim of this thesis was to evaluate and apply different methodologies important for personalised treatment in a variety of cancer settings. The first paper showed that E6/E7 mRNA detection through RT-NASBA is more accurate and sensitive than DNA genotyping for classifying HPV infection in cervical adenocarcinoma, showing RNA analysis to be preferable for identifying high-risk patients. In paper II, HPV16 E2 and E5 mRNA expression in oropharyngeal cancer was analysed in relation to clinical outcomes and tumour immunology. Neither down-regulation of HLA class I nor CD8+ T-cell infiltration, both indicators of good prognosis, were dependent on E2 or E5. However, absence of E2 was related to poor progression-free survival. This allows E2 expression to be combined with HLA class I and CD8+ T-cells when stratifying patients with good prognosis for milder treatment. The third paper screened combinations of growth factors and drugs for impact on proliferation of breast cancer cells, creating a two-dimensional space to simulate tumours in different signalling states interacting with drugs. In MDA-MB-231 cells, TGF-β in combination with EGF and oestrogen inhibited growth, with the effect strengthened by Tamoxifen. In MCF7 cells, Tamoxifen inhibited growth when added to both EGF and oestrogen. In paper IV, the immunoproteome in urinary bladder cancer was analysed. Proteomics and network analysis of regulatory (Treg) and effector T-cells (Teff) of lymph nodes showed that Tregs in sentinel nodes (SN) up-regulate growth and immune signalling networks. IL-16, previously not shown to be expressed by Tregs, was predicted as central to SN-Treg signalling. IL-16 expression in Tregs was validated, shown to be higher in lymph nodes than peripheral blood and inhibited by tumour cell supernatant. In conclusion, this thesis has shown methods to improve patient stratification in cervical adenocarcinoma and HPV-positive oropharyngeal cancer. The utility of proliferation screenings replicating tumour heterogeneity for optimising drug combinations was demonstrated, and finally, lymph node proteomics revealed individual differences in T-cell signalling, important for optimising immunotherapy. Integration of these and other methods will be key to arrive at personalised cancer medicine – application of the optimal treatment combination for every patient.List of scientific papersI. Hovland S, Muller S, Skomedal H, Mints M, Bergström J, Wallin KL, Karlsen F, Johansson B, Andersson S. E6/E7 mRNA expression analysis: a test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure. Int J Oncol. 2010 Jun;36(6):1533-9. https://doi.org/10.3892/ijo_00000640 II. Ramqvist T, Mints M, Tertipis N, Näsman A, Romanitan М, Munck-Wikland В, Dalianis T. Studies on Human Papillomavirus (HPV) 16 E2, E5 and E7 mRNA in HPV-positive Tonsillar and Base of Tongue Cancer in Relation to Clinical Outcome and Immunological Parameters. [Accepted] https://doi.org/10.1016/j.oraloncology.2015.09.007 https://doi.org/000366534000016III. Mints M, Souchelnytskyi S. Impact of combinations of EGF, TGFβ, 17β-oestradiol, and inhibitors of corresponding pathways on proliferation of breast cancer cell lines. Exp Oncol. 2014 Jun;36(2):67-71. https://pubmed.ncbi.nlm.nih.gov/24980758IV. Mints M, Krantz D, Winerdal М, Rutishauser D, Zubarev R, Zirakzadeh АA, Hansson J, Sherif A, Winqvist О. Individual proteomics on T-cell subsets in muscle-invasive urothelial bladder cancer patient lymph nodes reveals IL-16 as a central player in tumour-Treg cross-talk. [Manuscript]</p
Economic rebound versus imperial monopoly: Metal provenance of Early Medieval coins (9th–11th centuries) from some Italian and French mints
No full textThis paper represents the first systematic Pb isotope investigation of Italian Medieval coins and aims to provide new parameters for a general historical interpretation of coin production and circulation in Medieval Europe. We collected more than one hundred specimens, minted in a period between 9th − 14th centuries AD and coming mostly from archaeological sites of Tuscany. Here we report the results on the oldest group of (44) coins, dated between the end of the 9th and 11th centuries. All coins where previously characterized with handheld X-ray fluorescence (pXRF) analysis and lead isotope composition (PbIC) was performed using an MC-ICP-Mass Spectrometer. The Carolingian coins have PbIC compatible with Melle silver district; the few Carolingian coins possibly minted in Italy (Venice and Milan) are also compatible with ore districts such as Melle and Harz Mountains. Coins in the names of Italian rulers (9th-10th century) from Lucca, Pavia and other uncertain mints show PbIC compatible with Melle, Black Forest and the Harz Mountains as well. A quite similar pattern applies to coins in the names of Otto I-III and Conrad II (10th-11th century) from Lucca and Pavia mints, although they show a better overlap with the Harz Mountains. The vast majority of early medieval coins issued by the Italian mints investigated in the present paper show isotope compositions that do not match with silver (lead-copper) mines from the Colline Metallifere district of southern Tuscany, notwithstanding their exploitation in the considered period is suggested by many settlements located near mining sites
Context-free grammar multimedia intelligent tutoring system (CFG-MINTS)
No full textMultimedia Intelligent Tutoring System (CFG-MINTS) is intended for an introductory course Theory of Computation focusing on context-free grammars incorporating the use of multimedia in the teaching to improve instruction. An ITS is a computer-based tutorial that is capable of effectively detecting and correcting errors and misconceptions of the users by modeling the cognitive processes of its learner-users. The Tutor Model of this ITS is comprised of a set of strategies in teaching context-free grammar, a knowledge base consisting of rules specifying the best strategy to utilize, and an algorithm that determines which teaching action (rule) to be deployed given the goals of the system and the current state of the Student Model. The possible set of pedagogic action would consist of lessons, examples, drills for application and interactive question and answer. The Student Model uses the Constraint-Based Modeling (CBM) in understanding the current state of mind of the user. CBM reduces the complexity of student modelling by focusing only on the errors committed and the analysis is reduced to pattern matching. The assumption here is that there can be no correct solution of a problem that traverses a problem state, which violates the fundamental ideas, or concepts of the domain. The system also includes features for simulating the created context-free grammar to aid in teaching. MINTS Authoring Tool is an external facility that lets the user maintain the curriculum and student database used by CFG-MINTS
Economic rebound versus imperial monopoly: Metal provenance of Early Medieval coins (9th–11th centuries) from some Italian and French mints
No full textThis paper represents the first systematic Pb isotope investigation of Italian Medieval coins and aims to provide new parameters for a general historical interpretation of coin production and circulation in Medieval Europe. We collected more than one hundred specimens, minted in a period between 9th - 14th centuries AD and coming mostly from archaeological sites of Tuscany. Here we report the results on the oldest group of (44) coins, dated between the end of the 9th and 11th centuries. All coins where previously characterized with handheld X-ray fluorescence (pXRF) analysis and lead isotope composition (PbIC) was performed using an MC-ICP-Mass Spectrometer. The Carolingian coins have PbIC compatible with Melle silver district; the few Carolingian coins possibly minted in Italy (Venice and Milan) are also compatible with ore districts such as Melle and Harz Mountains. Coins in the names of Italian rulers (9th-10th century) from Lucca, Pavia and other uncertain mints show PbIC compatible with Melle, Black Forest and the Harz Mountains as well. A quite similar pattern applies to coins in the names of Otto I-III and Conrad II (10th-11th century) from Lucca and Pavia mints, although they show a better overlap with the Harz Mountains. The vast majority of early medieval coins issued by the Italian mints investigated in the present paper show isotope compositions that do not match with silver (lead-copper) mines from the Colline Metallifere district of southern Tuscany, notwithstanding their exploitation in the considered period is suggested by many settlements located near mining sites
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Comparison of pectic enzymes in resistant and susceptible mints infected by Verticillium dahliae
No full textVerticillium dahliae Kleb. incites a vascular wilt disease of
mints. Susceptible Mentha piperita L. , resistant M. crispa L.,
and intermediate hybrid 148 were used to study 1) the site of differential
resistance and 2) the role of polygalacturonase (PG) in the
disease syndrome.
Many more V. dahliae propagules were recovered from surface
sterilized, finely fragmented, susceptible mint roots than from resistant
roots. Therefore, the vascular system of susceptible mint was
more extensively invaded than resistant mint. Increase of Verticillium
in the stems was dependent on the extent of root invasion; severity
of foliar symptoms, in turn, was related to pathogen proliferation
in stems. These results indicate that the roots are the first
important site of differential resistance.
Inoculation through excised shoots showed that mint stems
differ in their resistance to Verticillium. Although Verticillium
increased similarly in stems of shoot inoculated resistant and susceptible
mints, severe symptoms developed only in susceptible
M. piperita; resistant M. crispa developed only slight symptoms.
PG activity was detected only by the reducing group assay in
extracts from diseased mint prepared without a phenolic adsorbent,
polyvinylpyrrolidone (PVP). In extracts prepared with PVP, PG
was detected by both the viscosity reduction and reducing group
assays. Enzyme extracts prepared late in disease when phenol
oxidase activity was high showed considerable decrease in viscosity
reducing power but not a decrease in reducing groups released
from substrate. These results indicate that Verticillium produced
an exo -PG in mint that was less affected by phenol oxidation products
than the endo -PG.
Increase of Verticillium and PG production was similar in
shoot inoculated resistant and susceptible mints. Foliar symptoms
developed only in susceptible M. piperita and intermediate resistant
hybrid 148. No foliar symptoms occurred in resistant M. crispa.
Resistance of mint to Verticillium apparently is not due to inactivation
of fungal PG.
PG production in mints during disease development showed no
relationship between symptom severity and PG activity in infected mint stems. A nonpathogen of mint produced PG activity in mint
similar to that produced by Verticillium but no wilt symptoms developed.
Hypotheses regarding the contribution of PG to wilt symptoms
depend on the formation of PGs in diseased plants that hydrolyze
pectic substances to large fragments. Enzyme extracts prepared
from plants as symptoms increased, liberated a high number of
reducing groups from substrate while the viscosity reducing power
decreased. This indicated that large pectic fragments are not
formed in plants. It was proposed that the role of PG in the
Verticillium wilt of mint disease is to provide an additional carbon
source for the pathogen
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