720 research outputs found
T.C. Powers, '25, author of the book, "Leakage: The Bleeding of the American Economy"
No full textIncludes letters from the American Society for Testing Material about T.C. PowersBlack and WhitePeople: Powers, T.C
Analysis of histone post translational modifications in primary monocyte derived macrophages using reverse phase×reverse phase chromatography in conjunction with porous graphitic carbon stationary phase.
No full textA two dimensional-liquid chromatography (2D-LC) based approach was developed for the identification and quantification of histone post translational modifications in conjunction with mass spectrometry analysis. Using a bottom-up strategy, offline 2D-LC was developed using reverse phase chromatography. A porous graphitic carbon stationary phase in the first dimension and a C18 stationary phase in the second dimension interfaced with mass spectrometry was used to analyse global levels of histone post translational modifications in human primary monocyte-derived macrophages. The results demonstrated that 84 different histone peptide proteoforms, with modifications at 18 different sites including combinatorial marks were identified, representing an increase in the identification of histone peptides by 65% and 51% compared to two different 1D-LC approaches on the same mass spectrometer. The use of the porous graphitic stationary phase in the first dimension resulted in efficient separation of histone peptides across the gradient, with good resolution and is orthogonal to the online C18 reverse phase chromatography. Overall, more histone peptides were identified using the 2D-LC approach compared to conventional 1D-LC approaches. In addition, a bioinformatic pipeline was developed in-house to enable the high throughput efficient and accurate quantification of fractionated histone peptides. The automation of a section of the downstream analysis pipeline increased the throughput of the 2D-LC-MS/MS approach for the quantification of histone post translational modifications
Controversies in the management of acute tonsillitis: an evidence-based review
No full textBACKGROUND: Patients admitted with acute tonsillitis generate a substantial workload for the National Health Service (NHS), placing huge financial pressures on an already overstretched budget.OBJECTIVE OF REVIEW: Due to the difficulty of accurate diagnosis and varying practices across the UK, there exist a number of controversial areas and non-standardised practice. These will be highlighted and tackled within this article.TYPE OF REVIEW AND SEARCH STRATEGY: A literature review, last performed in September 2013, searched PubMed citing variations on the areas of controversies with 'tonsillitis', 'pharyngitis' and 'pharyngotonsillitis' - from 1956 to present with language restrictions. Excluded articles included those regarding sore throat after tonsillectomy and peritonsillar abscess.EVALUATION METHOD: Titles and abstracts were initially screened, and full text of potentially relevant articles obtained. The bibliographies of articles were searched for relevant references. The references were then compiled and reviewed independently by two authors (JB & TB), overseen by the senior author (EK).RESULTS: (i) Diagnosis and investigation: Use of the Centor criteria is inadequate within the secondary care setting. Blood testing is unnecessary in the majority of cases where patients do not require admission, as they are unlikely to change management. (ii) Antibiotics: Antibiotics are likely to be indicated in all those presenting to secondary ENT care, with penicillin being the antibiotic of choice for first-line therapy. (iii) Corticosteroids: Moderate evidence supports the benefit of steroid administration in this patient cohort, advocating a single dose initially followed by reassessment. (iv) Analgesia: Paracetamol and NSAIDs have good evidence of action. Codeine should be used with caution in the paediatric population. (v) Reduced admission rates and early discharge: There is evidence suggesting that a trial of medical therapy prior to admission is beneficial in reducing rates of admission and length of stay.CONCLUSIONS: Management of acute tonsillitis within a secondary care setting largely consists of anecdotal or relatively low-quality evidence. Thus, much evidence from management comes from expert opinion or practice within a primary care setting. Management across the UK can also vary greatly. An evidence-based review of best practice has been presented here, but further evidence will be required in the future examining the significance of corticosteroids and antibiotic administration in this patient cohort specifically, ensuring practice is evidence based and clinically relevant.</p
(13(3):51-56)酸桔葉片殊形潰瘍病斑之利用
No full textCitrus canker caused by Xanthomonas citri (Hasse) Dowson is normally charac-terized by corky, hard, and somewhat suberized lesions surrounded by a yellowish halo on the infected leaves of susceptible varieties. If the canker lesion has developed quickly under extremely favorable conditions, the white spongy tissue will excruded in some degree, and accumulated on the lesions. This special canker lesions with spongy eruption of tissue will be found, sometime, when artificial inoculation was made by overstaying the inoculated plant in pot (Fig. 4) in the inoculation chamber for three or four days after inoculation. It is also easy to induce special lesions by keeping the leaves of susceptible varieties in such a semi-vivo condition as in the moistened Petri-dish (Fig. 3) placed in the incubator for five or six days after inoculation.
The present author was deeply interested in the formation of this special lesion and had made his attempt to utilize them for several purposes, such as screen test for canker-control bactericides, identrfication of newly isolated canker organism, and determination of resistance of citrus varieties to the disease. The present report was made in deal with utilization of this inoculation technique for testing inhibiting effectiveness of the bactericides on the fomation of canker lesion.
柑桔類潰瘍病於極度適宜之環境下所發生之病斑，因罹病組識之海棉細胞受病原菌之刺激致呈畸形膨大，多量溢出，而形成白色隆起之明顯殊形病斑，此種殊形病斑頗易由人工接種而顯現。將酸桔半成熟葉片採下，以自來水沖洗後以解剖針輕刺一定數目之傷痍，浸漬於病原菌懸浮液，使葉面餘液陰乾後排放於潮濕培養皿之玻璃支架上，置28℃定溫箱培養六天，即可於傷痍部位呈現明顯之殊形潰瘍病斑。
筆者以此病斑形成之明顯與容易，乃探測其利用價值。本試驗以五種抗生製劑供作傷痍葉片人工接種後作藥劑侵漬處理，以葉片病斑發生數目，測定供試藥劑對病原菌之抑制或殺減效力。據試驗結果，病斑之發生與藥劑濃度具有規律之相關關係。筆者認為此法於藥劑試驗之初步選定上，為一簡便而可行之方法
Smart Redundancy Schemes for ANNs against Fault Attacks
No full textArtificial neural networks (ANNs) are used to accomplish a variety of tasks, including safety critical ones. Hence, it is important to protect them against faults that can influence decisions during operation. In this paper, we propose smart and low-cost redundancy schemes that protect the most vulnerable ANN parts against fault attacks. Experimental results show that the two proposed smart schemes perform similarly to dual modular redundancy (DMR) at a much lower cost, generally improve on the state of the art, and reach protection levels in the range of 93% to 99%.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Computer EngineeringQuantum & Computer Engineerin
A bibliometric analysis of the performance of Water Research
No full text[[abstract]]This paper presents a detailed chronological survey of papers published in the journal titled Water Research which started publication since 1967. This current investigation reviews publication patterns between 1967 and 2008. An analysis of the research performance according to publication output, distribution of words in article title, author keywords, and keywords plus. Performances of countries, institutes, and authors, including total, single, collaborative, first author, and corresponding author publications were analyzed. The most-frequently cited articles each year and the articles of the highest impact in 2008 were also reported. Results showed that ‘‘activated sludge’’ was the most frequently used author keyword, followed by ‘‘adsorption,’’ and ‘‘drinking water.’’ Authors from 114 different countries/territories published in the journal, with the most articles submitted by authors from the USA
Acoustic mapping and monitoring of the seabed: From single-frequency to multispectral multibeam backscatter
No full textWith the increasing human activities in the marine environment, such as fisheries, dredging, coastal protection or construction of marine infrastructure, seabed sediment and habitat mapping have become highly relevant for the development of sustainable marine management strategies. Compared to traditional mapping methods, primarily based on bed sampling, multibeam echosounding belongs to the cutting-edge technology to time-efficiently acquire high-resolution bathymetric and backscatter (BS) data over large areas. Using classification methods to combine the acoustic data with ground-truthing, large-scale maps can be automatically and objectively produced, that enables to describe the distribution of benthic habitats or quantify marine resources. However, acoustic sediment classification still does not allow to discriminate between the entire heterogeneity of the seabed and is generally applied to a single multibeam echosounder dataset by means of revealing the seabed state only at a given time instant. Two challenging issues addressed within the scope of this thesis are summarized as: (1) Investigation on the applicability of repetitive multibeam (single-frequency) BS measurements for monitoring the seabed; and (2) Evaluation of the potential of multispectral BS to increase the acoustic discrimination between different seabed environments.Aircraft Noise and Climate Effect
Strain Fields in Crystalline Solids - Prediction and Measurement of X-Ray Diffraction Patterns and Electron Diffraction-Contrast Images
No full textApplied Science
Modelling of pile load tests in granular soils: Loading rate effects
No full textPeople have used pile foundations throughout history to support structures by transferringloads to deeper and stronger soil layers. One of the most important questions during the design of the pile foundation is the bearing capacity of the pile. The most reliable method for determining the bearing capacity is to use results from pile load tests. Traditionally, the static pile load tests have been used and more recent the dynamic tests. The rapid load test, at intermediate loading rates, was invented to overcome the disadvantages of the static tests (expensive and time-consuming) and the dynamic tests (the stress wave effects) and is conducted more and more in practice.Geo-engineerin
The natural history of North Carolina.
No full textReprint of the 1737 ed., with biographical notes on the author by T.C. Parramore, and an enl. index.Mode of access: Internet
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