186,817 research outputs found
Detecting Spatial Dependence in Panels with Common Factors through Permutations of Pesaran's CD(p) Test
No full textIn the spatial econometrics literature, spatial error dependence is characterized by spatial autoregressive processes, which relate every observation in the cross-section to any other with distance-decaying intensity: i.e., dependence obeys Tobler's First Law of Geography (''everything is related to everything else, but near things are more related than distant things''). In the literature on factor models, on the converse, the degree of correlation between cross-sectional units depends only on factor loadings.
Standard spatial correlation tests have power against both types of dependence, while the economic meaning of the two can be much different; so it may be useful to devise a test for detecting ''distance-related'' dependence in the presence of a ''factor-type'' one.
Pesaran's CD is a test for global cross-sectional dependence with good properties. The CD(p) variant only takes into account p-th order neighbouring units to test for local cross-sectional dependence. The pattern of CD(p) as p increases can be informative about the type of dependence in the errors, but the test power changes as new pairs of observations are taken into account.
I propose a permutation test based on the values taken by the CD(p) test under permutations of the neighbourhood matrix, i.e. when ''reshuffling the neighbours''. I provide Montecarlo evidence of it being able to tell the presence of spatial-type dependence in the errors of a typical spatial panel irrespective of the presence of an unobserved factor structure
Evaluación agronómica de genotipos de sorgo y millo (Sorghum vulgare) forrajeros para alimentación de bovinos en el medio Sinú
No full textObjetivo. Evaluar siete genotipos de millo y cinco genotipos de sorgo, para determinar el rendimiento forrajero y su utilidad en la alimentación de bovinos en el valle del medio Sinu. Materiales y métodos. Las semillas de sorgo y millo (Sorghum vulgare), fueron materiales híbridos y variedades tipo comercial. Se utilizó un diseño de bloques completos al azar con 4 cuatro repeticiones para millo y tres para sorgo. Resultados. Respecto al vigor los genotipos de millo que mejor comportamiento presentaron fueron el redondo cuba y blanco panoja larga; en sorgo el LC 603, el P-8239 y el DR-1125. Los millos que mostraron mayor senescencia fueron el cuarentano alto, el bastón y el blanco panoja larga; en sorgo los de mayor senescencia fueron el P-8239, el LC 603 y el 74 CO. La mayor producción de forraje verde y materia seca la presentaron los genotipos de millo, el batea cuba, el redondo cuba y el blanco panoja larga, los de sorgo fueron el blanco criollo y el DR-1125. El mayor rendimiento de grano fue de los genotipos el batea cuba y bastón en millo, y en sorgo fueron DR-1125 y LC 603. Se seleccionaron como materiales de buen comportamiento dentro de todos los evaluados el batea cuba, redondo cuba, y blanco panoja larga en millo y el blanco criollo y DR-1125 en sorgo. Conclusiones. Los genotipos de millo que mejor comportamiento presentaron fueron en su orden por rendimiento (ton/ha): el batea cuba, el redondo cuba y el blanco panoja larga (ton/ha), obteniéndose una mayor capacidad de carga animal. Los genotipos de mejor comportamiento de sorgo fueron el blanco criollo y el DR-1125
Are funding of pensions and economic growth directly linked? New empirical results for some OECD countries
No full textWe empirically test on a panel of OECD countries the hypothesis of a direct and positive link between funding of pensions and economic growth, which is based on the idea that richer pension systems can accelerate the development of the financial system and thus promote a more efficient capital allocation. We follow Davis and Hu (2008) in estimating a modified Cobb-Douglas production function where pension fund assets are treated as a shift factor, but in line with the recent econometric literature we control for common global shocks driving per capita outputs. Therefore we adopt a more general approach suitable to the presence of a multifactor error structure. The previous evidence of a long run cointegration relationship between autonomous (or total) pension fund assets and per capita output for our panel of OECD countries is not robust to our augmented specification
Rescuing defective CFTR applying a drug repositioning strategy based on computational studies, surface plasmon resonance and cell-based assays
No full textCystic Fibrosis (CF) is caused by mutations (mainly F508del) of the
cystic fibrosis transmembrane conductance regulator (CFTR). Current
CF therapies are aimed at symptoms alleviation, calling for new
drugs to rescue CFTR function.
Hypothesis and objectives
Drug repositioning is aimed at finding new applications for already
marketed drugs, reducing cost and duration and the likelihood of
unforeseen adverse events. In this project we have integrated drug
repositioning with computational studies, surface plasmon resonance
(SPR) [1] and well-tried cellular models [2] to identify new CF drugs
and to comprehend their mechanism of action.
Methods and results
We have prepared a new structural homology model of intact human
F508del-CFTR embedded in a phospholipid bilayer and a SPR biosensor
containing the same protein in a cell membrane-mimicking lipid
film.
These tools, along with appropriate cell-based assays, have been
firstly used to analyze a mixed library of well-known and new compounds
that allowed the validation of the system and the identification
of a promising molecule endowed with a F508del-binding and
rescuing capacity that is higher than those of drugs already in use.
With the computational model we have then performed a virtual
drug repositioning on a library of 846 drugs, identifying 10 drugs
that were reduced to 4 on the basis of toxicity profile and patient
compliance. These drugs will be now subjected to experimental analysis
by cell-based and SPR assays for their effective capacity to bind
F508del-CFTR and rescue its activity. Also, we will proceed to the virtual
repositioning of a library of natural compounds.
Spin-off for research & clinical purposes
The novel computational models and biosensors will widen the study
of CF drugs and made available to other research groups in the field
of CF.
References
1. Rusnati M, Sala D, Orro A, Bugatti A, Trombetti G, Cichero E, Urbinati C,
Di Somma M, Millo E, Galietta LJV, Milanesi L, Fossa P, D'Ursi P. Speeding
Up the Identification of Cystic Fibrosis Transmembrane Conductance
Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies
and Surface Plasmon Resonance. Molecules. 2018 Jan 8;23(1). pii:
E120. doi: 10.3390/molecules23010120.
2. Tomati V, Pesce E, Caci E, Sondo E, Scudieri P, Marini M, Amato F,
Castaldo G, Ravazzolo R, Galietta LJV, Pedemonte N. High-throughput
screening identifies FAU protein as a regulator of mutant cystic fibrosis
transmembrane conductance regulator channel. J Biol Chem. 2018 Jan
26;293(4):1203-1217. doi: 10.1074/jbc.M117.816595. Epub 2017 Nov 20.
Acknowledgment FFC#11/2018 funded by FFC and supported by Delegazione
FFC di Torin
Agronomic parameters of Millo Corvo, Ottofile and Scagliolo cultivars cultivated at Landriano (PV).
No full text<p>Confidence Intervals at 95% are shown, n > 50.</p><p>Agronomic parameters of Millo Corvo, Ottofile and Scagliolo cultivars cultivated at Landriano (PV).</p
RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy
No full textThe ability to evade apoptosis is one of the defining hallmarks of cancer. It enables the survival of cancer cells under abnormal growth stimulation and mediates their increased resistance to treatment with cytotoxic drugs and radiation. Therefore, antiapoptotic proteins that counteract apoptosis signaling represent promising new therapeutic targets to impair cancer cell growth and enhance treatment response. As soon as RNA interference (RNAi) was demonstrated in mammalian cells, it rapidly became an essential tool for gene knockdown in preclinical models, making it possible to define the role of specific genes in the onset and progression of cancer and explore their potential as therapeutic targets. The present review summarizes the findings from studies relying on the use of RNAi-based approaches to functionally validate two members of the inhibitors of apoptosis protein family, survivin and Apollon/BRUCE, as new cancer therapeutic targets. Results collected thus far indicate that targeting the survivin network efficiently inhibits tumor growth potential and increases spontaneous and treatment-induced apoptosis of cancer cells. Based on these findings, the applicability of survivin-directed strategies for the clinical treatment of human tumors is currently under investigation. As regards Apollon/BRUCE, although very preliminary, results of RNAi-mediated gene knockdown point to the possibility to significantly impair tumor cell proliferation through the induction of apoptosis
Propuesta didáctica para la ejecución de la flauta de Millo. "Diálogo de saberes".
No full textEl presente trabajo se basa en la creación de una propuesta didáctica, nutrida de los saberes que brindan la tradición oral y los diferentes referentes escritos consultados. Esta propuesta, permite al estudiante aprender a ejecutar la flauta de millo, mediante el ejercicio vivo de la música, a través de temas creados en carácter secuencial que permitan al estudiante, apropiar cada una de las técnicas necesarias para la ejecución de este instrumento.Licenciado en MúsicaTesis de pregrad
Evaluación agronómica de genotipos de sorgo y millo (Sorghum vulgare) forrajeros para alimentación de bovinos en el medio Sinú
No full textObjective. To evaluate seven millo and five sorghum genotypes to determine forage yield and to use it in feeding bovine in Sinú valley, Colombia. Materials and methods. Sorghum (Sorghum vulgare) and millo seeds were hybrid materials and commercial type varieties. A design of complete blocks at random was used with four repetitions for millo and three for sorghum. Results. Regarding vigor the genotypes that better behavior presented were the round Cuba and white long panicle for millo and LC 603, P-8239 and DR-1125 for sorghum. The millos that showed bigger senescence was the high cuarentano, the cane and the white long panicle; in sorghum those of more senescence were P-8239, LC 603 and 74 CO. Biggest production of green forage and dry matter were presented by millo, Batea Cuba, Round Cuba and white long panicle genotypes, for sorghum were Blanco Creole and DR-1125. The biggest yield grain was of batea Cuba and cane genotypes in millo, and in sorghum were DR-1125 and LC 603. As materials of good behavior inside all those evaluated were selected the Batea Cuba, Round Cuba, and white long panicle in millo and Blanco Creole and DR-1125 in sorghum. Conclusions. The millo genotypes that better behavior presented were in its order for yield (ton/ha): batea Cuba, round Cuba and white long panicle (ton/ha), being obtained a bigger capacity of animal load. The genotypes of better behavior of sorghum were Blanco Creole and DR-1125.Objetivo. Evaluar siete genotipos de millo y cinco genotipos de sorgo, para determinar el rendimiento forrajero y su utilidad en la alimentación de bovinos en el valle del medio Sinu. Materiales y métodos. Las semillas de sorgo y millo (Sorghum vulgare), fueron materiales híbridos y variedades tipo comercial. Se utilizó un diseño de bloques completos al azar con 4 cuatro repeticiones para millo y tres para sorgo. Resultados. Respecto al vigor los genotipos de millo que mejor comportamiento presentaron fueron el redondo cuba y blanco panoja larga; en sorgo el LC 603, el P-8239 y el DR-1125. Los millos que mostraron mayor senescencia fueron el cuarentano alto, el bastón y el blanco panoja larga; en sorgo los de mayor senescencia fueron el P-8239, el LC 603 y el 74 CO. La mayor producción de forraje verde y materia seca la presentaron los genotipos de millo, el batea cuba, el redondo cuba y el blanco panoja larga, los de sorgo fueron el blanco criollo y el DR-1125. El mayor rendimiento de grano fue de los genotipos el batea cuba y bastón en millo, y en sorgo fueron DR-1125 y LC 603. Se seleccionaron como materiales de buen comportamiento dentro de todos los evaluados el batea cuba, redondo cuba, y blanco panoja larga en millo y el blanco criollo y DR-1125 en sorgo. Conclusiones. Los genotipos de millo que mejor comportamiento presentaron fueron en su orden por rendimiento (ton/ha): el batea cuba, el redondo cuba y el blanco panoja larga (ton/ha), obteniéndose una mayor capacidad de carga animal. Los genotipos de mejor comportamiento de sorgo fueron el blanco criollo y el DR-1125
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