39 research outputs found
Cascade reactions of glycine Schiff bases and chiral phase transfer catalysts in the synthesis of alfa-amino acids 3-substituted phthalides or isoindolinones
No full textThe tuning of aldol/cyclization cascade reactions of glycine Schiff
bases with 2-cyano benzaldehydes provides access to non-natural
a-amino acid derivatives substituted alternatively with phthalides or
isoindolinones, depending on the strength of the used base.Moreover,
a preliminary screening of catalysts and conditions for development of
asymmetric versions identified chiral bifunctional phase transfer
catalysts as particularly promising, leading to the alfa-amino esters
3-substituted phthalides in high yields and good diastereo- and
enantioselectivit
The aldol addition of readily enolizable 1,3-dicarbonyl compounds to 2-cyanobenzaldehyde in the synthesis of novel 3-substituted isoindolinones
No full textThe aldol addition of readily enolizable 1,3-dicarbonyl compounds to 2-cyanobenzaldehyde in the presence of a tertiary amine led to a series of new 3-substituted isoindolinones. Despite the instability of the related aldols, this synthesis was possible because of the intramolecular trapping of the adducts with the cyano group due to a tandem process of cyclization-rearrangement. Simple decarboxylation of some derivatives gave access to some very useful compounds
Finite element analysis of miniscrew placement in mandibular alveolar bone with varied angulations
No full textSummary Background: Titanium miniscrews are increasingly used as orthodontic anchorage. Various factors are known to affect the stability of miniscrew. Placement angle is one of the most controversial issues in this area. Thus, the aim of this finite element study was to evaluate the influence of placement angle and direction of force on the stability of miniscrews. Materials and methods: Finite element analysis was performed using miniscrews inserted into 1mm of cortical bone and 10mm of trabecular bone at angles of 30, 60, 90, 120, and 150 degrees to the alveolar bone. Force of 2 Newton (N) was applied to the heads of the miniscrews in two directions of 0 and 30 degrees. Results: The finite element analysis showed that inserting miniscrews at 90 degree angle would provide better anchorage than 30, 60, 120, and 150 degree angles at either direction of force. The least trabecular bone von Mises stress was 5.6MPa at 90 degrees at both directions of force and the least cortical bone stress was 31.2MPa at 90 degrees at both directions of force. Conclusions: Insertion of miniscrews at angles less than or greater than 90 degrees to the alveolar process bone might decrease the anchorage stability of the miniscrew. © The Author 2014. Published by Oxford University Press on behalf of the European Orthodontic Society
Diagnostic Delay in Adolescents with Cancer During COVID-19 Pandemic: A New Price for Our Patients to Pay
No full textWorldwide, the coronavirus 19 disease pandemic caused a worse chance of a timely diagnosis for cancer patients. We conducted a retrospective analysis of new diagnoses registered in the national pediatric oncology database, comparing the first lockdown period (March-May 2020) with the same period of 2015-2019. The total number of cases (0-19 years) dropped by 20.8% (from 441 between 2015 and 2019 to 349 in 2020). A major reduction was observed for adolescents (15-19 years) (-32.9%) and for adolescents with solid tumors (-56.4%, p = 0.03). Our data suggest that the enforced lockdown reduced the possibility for these already vulnerable patients to access the referral centers
The impact of a CO2 reduction target on the private car fleet in the netherlands
No full textClimate change mitigation calls for a massive reduction in CO2-emissions from human sources. A primary human source is combustion of fossil fuels. Transport by road is one of the major and growing users of fossil fuels worldwide. Private cars with internal combustion engines dominate our roads. This paper discusses the feasibility of aligning CO2-emissions of private cars with the Paris Climate Agreement for 2030. It starts in 2010. Country of study is The Netherlands. The relation between climate change and air pollution is taken aboard. The following research questions will be addressed: How many private cars were there in The Netherlands, how many kilometres were driven and what were their CO2, NOx and PM10 emissions in 2010? What would these values be in the year 2030 assuming continuation of current trends in technology and policy? What could these values be if there were only full electric vehicles (FEV) on the road by 2030? Would behavioural change be necessary to reach the national CO2-reduction target for 2030? In the simulation model assumptions were used about car ownership and volume, electric cars, fuel efficiency and electricity mix. Car production could be limited to the most fuel-efficient and lowest emission electric cars. Buyers’ choice would become restricted. Fulfilling the Dutch CO2-emission reduction target for 2030 is only possible by using state-of-the-art technology in a fleet of 100% full electric cars (FEV) and a major reduction in yearly car kilometres (either per car or via fewer cars). This assumes a revolution in car production and sales and an active mobility reduction and modal shift policy. The first has just started, while the second and third are unlikely after decades of liberal policy-making, which has stimulated car mobility by expanding the road network, increasing maximum speeds and cutting public transport budgets.Transport and Plannin
Recommended from our members
Contracts /
No full text"The author provides a detailed treatment of the basic rules, principles, and issues in contracts. Topics covered include offer and acceptance, parol evidence and interpretation, consideration, promissory estoppel, contracts under seal, capacity of parties, conditions, performance, and breach. The author also discusses damages, avoidance and reformation, third-party beneficiaries, assignments, and the statute of frauds. The discharge of contracts and illegal bargains are also the subject of separate chapters."--Publisher
Ignoring and Encountering the Tragic Neighbor Through the Built Environment
No full textIn this essay the author claims that redevelopment of public space and the built environment does more than just relocate people; it redefines them as well. After detailing how people have been redefined in the efforts of city redevelopment using San Francisco as a case study, an analysis of Ivan Illich\u27s reading of the Good Samaritan story is provided in order to suggest what type of moral imagination and practices are required as cities are redeveloped. This analysis emphasizes the critical importance of bodily presence when serving another and a willingness to accept a degree of the tragic in everyday life
La natura e Dio secondo Spinoza. Alcuni rilievi critici da un punto di vista tomistico
No full textThe author illustrates the fundamental notions of Spinoza’s philosophy (substance, God and nature) and underlines their origin in the historical and cultural
context. He then goes on to highlight the presupposition of the Spinozian position which
is the identity of being and thought. From the Thomistic point of view, such a position
shows many weaknesses, because it fails to grasp a real ontological distinction between
God and created beings. In fact, it does not adequately consider that the human being
knows starting from the real beings and only in this way he can come to discover the distinction between being and essence: L’autore illustra le nozioni fondamentali della filosofia di Spinoza (sostanza, Dio e natura) e sottolinea la loro origine nel contesto storico e culturale. Egli
passa poi a evidenziare il presupposto della posizione spinoziana che è individuato
nell’identità di essere e pensiero. Dal punto di vista tomistico, una tale posizione mostra molte debolezze, perché non riesce a cogliere una reale distinzione ontologica
tra Dio e gli enti creati. Infatti, essa non considera adeguatamente che l’ente umano
conosce a partire dall’ente reale e soltanto in questo modo può giungere a scoprire la
distinzione tra essere ed essenza
Toward the future community care: a multi-step exploratory study from a service & systems perspective focused on the key role of technology
No full text2021 - 2022In our fast-changing world, management and marketing acquire a strategic relevance. They
become an important reference and support when it comes to making healthcare more effective,
efficient, and sustainable. A key contribution in achieving these goals is played by a systems
governance and management of healthcare (Pollard, 2016); hence, by the adoption of a systems
approach (Golinelli, 2000, 2010; Barile 2000, 2009).
Due to an ageing population and the growing number of patients with comorbidity, the
number of patients with chronical illnesses (for which there may not be a cure) is growing.
This situation highlights the need to define governance policies capable of ensuring the
sustainable development of the economic and social system through appropriate forms of
organization.
In this problematic context, a need to understand and interpret the complexity of service
systems and social phenomena using general schemes of interpretation, arises. Essentially, the
complex goal is to balance the effectiveness, efficiency and sustainability of service in the
governance of the healthcare system (Saviano, Bassano, & Calabrese, 2010). Accordingly, this
study aims to investigate the evolutionary trend of change that the Italian Healthcare System is
facing now in order to make healthcare service more effective, efficient and sustainable using
the lens of systems thinking as a valid interpretative support of complex phenomena.
On the basis of this premise and considering the widely agreed need of increasing
community care, especially experienced during the COVID-19 pandemic, more specifically,
this work aims to investigate the conditions of the effectiveness, efficiency, sustainability, and
also safety, of healthcare services while shifting from the hospital setting to community and
home care.
This shift is rich of implications and, although hospital care is in actual fact the highest level
of assistance in both structural and organizational terms, it may result much more complex to
effectively, efficiently and sustainably organize care at a community and home care, given the
need of integrating many diverse systems components. .. [edited by Author]XXXV cicl
