1,721,002 research outputs found
75th anniversary of the discovery of angiotensin: a tale of two countries
Full text linkThis paper was written in collaboration between the University of Perugia, Italy and the Instituto de Investigaciones Cardiolo´ gicas, Universidad de Buenos Aires-Conicet, ArgentinaFil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Provenzano, Sergio. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Ambrosio, Giuseppe. Universita Di Perugia; Itali
A cornerstone in the history of hypertension: The seventieth anniversary of the discovery of angiotensin
Full text linkIn 1939, two independent teams, in Buenos Aires and Indianapolis, identified the polypeptide angiotensin. In 1934, Goldblatt et al. demonstrated that partial occlusion of the renal arteries produces hypertension in dogs, and Houssay in 1936 predicted the presence of a humoral mechanism and, with Fasciolo, demonstrated that the ischemic kidneys released a pressor substance that increased the recipient's blood pressure. Later on, Taquini proved that the rise in blood pressure that follows the re-establishment of circulation in kidneys was also produced by a plasmatic substance from the venous blood of acute ischemic kidneys and it was called 'hypertensin'. Then, they proved that it was the result of an enzymatic reaction in which renin was the enzyme and plasma the substrate. At the same time, in 1939, Page et al. postulated that renin activated by plasma becomes vasoactive and the substance was called 'angiotonin'. Page's group began in 1937, with the purification of renin, studying its renal hemodynamic effects. Later on, Page et al. acknowledged in 1943 the enzymatic nature of the system and renamed their so-called renin-activator as renin substrate. Both groups fused the two original names into 'angiotensin' during a meeting at Michigan in 1958, making the 'adventure of the discovery of angiotensin' a reality. © 2010 Italian Federation of Cardiology.Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Oxidative stress and mitochondrial damage in coronary artery bypass graft surgery: Effects of antioxidant treatments
Full text linkWe examined antioxidant actions in 73 patients undergoing coronary artery surgery by assessing mitochondrial damage and oxidative stress in ventricular biopsies obtained at preischemia and postreperfusion. Those patients who received antioxidant therapy benefited by less oxidative stress and mitochondrial damage.Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Ferreira, Ricardo. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentin
Effect of doxycycline on atherosclerosis: From bench to bedside
Full text linkMatrix metalloproteinases (MMPs) have a pivotal role in the natural history of atherosclerosis and its cardiovascular consequences. Non-selective MMP inhibition with doxycycline appears as a potential strategy to reduce the residual risk observed in patients already at intensive lipid lowering strategies. However, specific MMPs have different and even contradicting roles in the natural history of atherosclerosis, rendering broad spectrum MMP inhibition an important yet somewhat simplistic approach towards residual risk reduction in coronary atherosclerosis. Overall, the balance of non-selective MMP inhibition might shift to the favorable side in particular settings such as in acute coronary syndromes, where in addition to its potential plaque stabilization properties, doxycycline shows promise in preventing ischemia-reperfusion injury and left ventricular remodeling. Nevertheless, to date, most animal models used do not represent advanced coronary atherosclerosis seen in humans, and large and well-designed clinical studies are lacking. We discuss the available evidence and recent patents supporting the role of doxycycline in atherosclerosis.Fil: Rodriguez Granillo, Gaston Alfredo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodriguez Granillo, Agustina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentin
Factores psicosociales de riesgo en la enfermedad cardíaca
Full text linkEl presente trabajo tiene por objeto la revisión sistemática de artículos que asocian los factores psicosociales con la enfermedad coronaria, publicados entre 1980 al 2010 La búsqueda bibliográfica se efectúo de forma sistemática, a través de bases de datos y fue completada manualmente sobre la base de las listas de referencias. Finalmente se seleccionaron 59 artículos científicos que fueron analizados de acuerdo a su contenido conforme al objetivo de la revisión. Se concluye que existe un extenso cuerpo teórico que fundamenta la asociación entre los factores psicosociales y la enfermedad coronaria, justificando la emergencia de la cardiología conductual como aquella rama de la psicología que atiende dichos factores en relación al enfermar cardíaco. La revisión arroja algunas sugerencias para futuras investigaciones en relación a la temática.The present paper aims at reviewing the empirical work which links psychosocial factors with cardiac disease and was published between 1980 and 2010. The literature search was conducted systematically, on databases and was completed manually on the basis of reference lists. Finally, 59 scientific articles were selected and analyzed thematically in accordance to the aim of this review. The conclusion is that there is an extensive theoretical corpus that supports the association between psychosocial factors and coronary disease. This justifies the appearance for behavioral cardiology as the branch of psychology which studies these factors in relation to cardiac disease. This paper presents suggestions for future research in connection to these topics.Fil: Pereyra Girardi, Carolina Iris. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentin
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Kinking of carotid arteries is not a mechanism of cerebral ischemia: a functional evaluation by Doppler echography
Full text linkAim: To evaluate the hemodynamic behavior of carotid kinking, as assessed by color Doppler ultrasonography at baseline and during neck movements, and their relation to neurological symptoms. Methods: In this cross-sectional study, 60 consecutive patients with non atheromatous carotid kinking in whom diagnostic color Doppler ultrasonography investigation of neck vessels had been requested for clinical suspicion of atherosclerotic disease were evaluated. To evaluate if there were significant changes of blood velocities as a consequence of kinking, for each carotid artery we recorded systolic and diastolic velocities both in the segments proximal to kinking, as well as intra-kinking. And the effects of postural changes and neck movements on carotid blood flow were also studied. Results: Flow in carotid arteries with kinking was always normal, and no differences were found between flow velocity measured at the level of kinking compared to the normal tract of the vessel. During head rotation tests, flow remained largely unaffected, a substantial reduction in the velocities in the ophthalmic artery was found in 13.5% of the cases, while an increase was recorded in 27%; and no symptoms or events were recorded during the study. None of the patients referred symptoms, nor were neurological events or signs detected during the maneuvers. Conclusion: Our results show that carotid kinkings are not a mechanism of acute cerebral ischemia, and therefore are unlikely to be a cause of neurological events or symptoms.Fil: Beigelman R.Fil: Izaguirre AM.Fil: Robles M.Fil: grana.Fil: Ambrosio G.Fil: Milei, Jose
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Carvedilol protects the peritubular capillaries and kidney structure in spontaneously hypertensive rats
Full text linkCarvedilol improves autoregulation of renal blood flow by virtue of its ability to reduce intrarenal vascular resistance [1] and modify the vascular reactivity in non-denervated kidney [2]. Long-term changes in renal blood flow, for example during essential hypertension, may induce progressive modifications in the microvascular (MV) tone, given that the chronic vascular constriction can lead to peritubular capillary loss and increased intrarenal vascular resistance. The severity of these changes may affect the kidney functions, a phenomenon known as vascular rarefaction [3].Fil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Ottaviano, Graciela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Gómez Llambí, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentin
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