130,688 research outputs found
Supersession Intercluster SITDA
No full textSupersession Intercluster Presentation. In the context of the “Networks Markets & People” International Symposium, the Italian Society of Architectural Technology organized the Supersession Intercluster SITdA “Pre-design and energy-environmental design for decarbonisation. Scenarios from applied research”, with four sessions:
– Regenerative Design and Impact Assessment for Climate Adaptation (C. Nava, M. Losasso, F. Tucci, V. D’Ambrosio, G. Mangano)
– Circular Design and process efficiency with reduction of waste, material and energy consumption (F. Giglio, E. Antonini, M. F. Ottone, D. Lucanto)
– From Nearly Zero Energy to Climate Neutral Architecture (M. Milardi, P. Davoli, P. Gallo, M. T. Mandaglio)
– Tech-Driven Architectural Transitions for Future Cities (C. Trombetta, C. Sposito, F. Angelucci, S. Cascone
Editorial: Testicular Cancer: New Insights on the Origin, Genetics, Treatment, Fertility, General Health, Quality of Life and Sexual Function
No full textCorrigendum: Editorial: Testicular Cancer: New Insights on the Origin, Genetics, Treatment, Fertility, General Health, Quality of Life and Sexual Function (Frontiers in Endocrinology, (2020), 11, (41), 10.3389/fendo.2020.00041)
No full text[This corrects the article DOI: 10.3389/fendo.2020.00041.]
Male fertility and reduction in semen parameters: A single tertiary-care center experience
No full textBackground. Infertility is both a clinical and a public problem, affecting the life of the couple, the healthcare services, and social environment. Standard semen analysis is the surrogate measure of male fertility in clinical practice. Objective. To provide information about the relationship between semen parameters and spontaneous conception. Methods. We evaluated retrospectively 453 pregnancies that occurred among 2935 infertile couples evaluated at an infertility clinic of a tertiary-care university hospital, between 2004 and 2009. Results. Normal semen analysis was present only in 158 patients; 295 subfertile patients showed alterations in at least one seminal parameter. A reduction in all seminal parameters was observed in 41 patients. Etiological causes of male infertility were identified in 314 patients. Conclusion. Our data highlights the possibility of a spontaneous conception with semen parameters below WHO reference values. Therefore, we support the importance of defining reference values on a population of fertile men. Finally, we analyzed the related ethical issues. Copyright © 2012 D. Milardi et al
Periodontal probing vs computed tomography: the accuracy and benefit for a proper diagnosis of periodontal disease
No full textImaging of temporomandibular joint: Approach by direct volume rendering
No full textMaterials and Methods: We have studied the temporom-andibular joint anatomy, directly on the living, from 3D images obtained by medical imaging Computed Tomography and Nuclear Magnetic Resonance acquisition, and subsequent re-engineering techniques 3D Surface Rendering and Volume Rendering. Data were analysed with the goal of being able to isolate, identify and distinguish the anatomical structures of the joint, and get the largest possible number of information utilizing software for post-processing work.Results: It was possible to reproduce anatomy of the skeletal structures, as well as through acquisitions of Magnetic Resonance Imaging; it was also possible to visualize the vascular, muscular, ligamentous and tendinous components of the articular complex, and also the capsule and the fibrous cartilaginous disc. We managed the Surface Rendering and Volume Rendering, not only to obtain three-dimensional images for colour and for resolution comparable to the usual anatomical preparations, but also a considerable number of anatomical, minuter details, zooming, rotating and cutting the same images with linking, graduating the colour, transparency and opacity from time to time.Conclusion: These results are encouraging to stimulate further studies in other anatomical districts.Background: The purpose of this study was to conduct a morphological analysis of the temporomandibular joint, a highly specialized synovial joint that permits movement and function of the mandible
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Synthesis, biophysical characterization and anti-HIV activity of d(TG3AG) Quadruplexes bearing hydrophobic tails at the 5'-end
No full textNovel conjugated G-quadruplex-forming d(TG3AG) oligonucleotides, linked to hydrophobic groups
through phosphodiester bonds at 50-end, have been synthesized as potential anti-HIV aptamers, via a
fully automated, online phosphoramidite-based solid-phase strategy. Conjugated quadruplexes showed
pronounced anti-HIV activity with some preference for HIV-1, with inhibitory activity invariably in the
low micromolar range. The CD and DSC monitored thermal denaturation studies on the resulting quadruplexes,
indicated the insertion of lipophilic residue at the 50-end, conferring always improved stability
to the quadruplex complex (20 < DTm < 40 C). The data suggest no direct functional relationship
between the thermal stability and anti-HIV activity of the folded conjugated G-quartets. It would appear
that the nature of the residue at 50 end of the d(TG3AG) quadruplexes plays an important role in the thermodynamic
stabilization but a minor influence on the anti-HIV activity. Moreover, a detailed CD and DSC
analyses indicate a monophasic behaviour for sequences I and V, while for ODNs (II–IV) clearly show that
these quadruplex structures deviate from simple two-state melting, supporting the hypothesis that intermediate
states along the dissociation pathway may exis
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