5 research outputs found
Neutrophil-to-lymphocyte ratio for predictor of in-hospital mortality in ST-segment elevation myocardial infarction: a meta-analysis
No full textBACKGROUND ST-segment elevation myocardial infarction (STEMI) is the most life-threatening condition of acute coronary syndrome that carries a poor prognosis of in-hospital mortality. Multiple scoring systems have been developed to predict in-hospital mortality and other cardiovascular events. Neutrophil-to-lymphocyte ratio (NLR) is hardly used as a predictor of in-hospital mortality. This study was aimed to determine the predictive value of NLR concerning in-hospital mortality in STEMI patients.
METHODS Literature search and pooled analysis related to studies on MEDLINE/PubMed, EBSCO, Science Direct, Cochrane, and ProQuest were retrieved. Inclusion criteria were met if they were cohort studies, the subjects were STEMI patient, contained pretreatment NLR cut-off, and considered in-hospital mortality, which is defined as cardiac or all-cause mortality. Quality assessment was conducted using Newcastle-Ottawa scale. Review Manager version 5.3 (The Nordic Cochrane Centre, Copenhagen) was used for meta-analysis.
RESULTS We found 12 studies with a total of 7,251 STEMI subjects with median NLR cut-off value of 5.6. Elevated NLR on admission carries a high risk of in-hospital mortality (odds ratio [OR] = 3.00, 95% confidence interval [CI] = 2.46–3.67). A slightly higher risk of all-cause mortality (OR = 2.74, 95% CI = 1.99–3.77) was observed compared with cardiac-related mortality (OR = 3.20, 95% CI = 2.47–4.14). No significant heterogeneity was observed between these studies (p = 0.46, I2 = 0%).
CONCLUSIONS Elevated NLR predicts a higher in-hospital mortality rate of STEMI patients
The Correlation of IL-6 Levels With the Degree of Rheumatoid Arthritis Disease Activity at Dr. Mohammad Hoesin Palembang
No full textRheumatoid arthritis (RA) is an autoimmune disease that requires careful management and regular evaluation of the degree of disease activity. AR is known for its pathophysiology and is strongly influenced by the increase of proinflammatory cytokines, especially IL-6. This study was conducted to determine the correlation of IL-6 levels with the degree of disease activity in AR patients at Dr. Mohammad Hoesin Palembang. A cross-sectional study was conducted on RA patients at the Rheumatology Polyclinic, Department of Internal Medicine, Dr. Moh Hoesin Palembang, who met the inclusion criteria consecutively in October 2021. The degree of RA disease activity was assessed using the Disease Activity Score (DAS 28). Statistical analysis was performed using SPSS version 24.0. A total of 34 subjects participated in the study, with most being women and a median age of 49.5 years. The majority of subjects had a moderate-high degree of RA activity. There is no significant correlation between IL-6 levels with DAS 28 CRP (r=0.256, p=0.072) and DAS 28 LED (r= 0.056, p=0.376). There was no significant correlation between serum IL-6 levels and disease activity in Rheumatoid Arthritis patients at Dr. Mohammad Hoesin Palembang
Profil Fibrilasi Atrium di RSUD Kabupaten Belitung Timur Tahun 2014-2016
No full textLatar Belakang. Atrial Fibrilasi (AF) merupakan aritmia yang paling sering ditemukan. Data epidemiologis profil pasien AF di rumah sakit tipe D di Indonesia masih kurang. Tujuan. Menyediakan data epidemiologis pasien AF di RSUD Kab. Belitung Timur 2014-2016. Metode. Penelitian berbasis rekam medis pasien AF yang dirawat inap di RSUD Kab. Belitung Timur selama tahun 2014-2016. Variabel yang dihimpun meliputi karakteristik sosiodemografi, komorbid, elektrokardiogram, terapi antiaritmia, angka mortalitas. Hasil.Terdapat 69 kasus AF rawat inap dari tahun 2014-2016; 35 orang (50,7%) laki-laki dan 34 orang (49,3%) perempuan, mayoritas (36,2%) berumur 60-75 tahun. Keluhan utama yang paling sering adalah sesak napas (59,4%), penurunan kesadaran (13,9%), dan berdebar-debar (8,7%). Mayoritas (55,1%) menderita AF respon ventrikel cepat. Didapatkan juga hipertensi (76,8%), gagal jantung (73,9%), infeksi akut (42%), penyakit serebrovaskuler (11,6%), penyakit ginjal kronis (10,1%), anemia (8,7%), Diabetes Mellitus tipe 2 (7,2%), dan penyakit hipertiroid (2,9%). Obat yang paling sering digunakan (39,1%) adalah kombinasi bisoprolol dan digoxin. Angka kematian dalam rumah sakit akibat semua penyebab sebesar 15,9%.Background. Atrial Fibrillation (AF) is the most common arrhythmia encountered in clinical practice. There is lack of epidemiological data on AF patient profile in rural hospital in Indonesia. Purpose. To provide epidemiological data of hospitalized AF patient in RSUD Belitung Timur from 2014 to 2016. Methods. Review of medical records of AF patients in RSUD Belitung Timur from 2014-2016. Relevant variables such as demographic and clinical characteristics, electrocardiogram, antiarrhytmia therapy and mortality rate were documented. Results. Sixty nine cases of atrial fibrillation from 2014-2016 were analyzed. There were 35 (50.7%) male dan 34 (49.3%) female, majority (36.2%) were 60-75 years old. The most common main symptoms were dyspnea (59.4%), loss of consciousness (13.9%) and palpitation (8.7%). Most patients (55.1%) had Rapid Ventricular Response. They also had hypertension (76.8%), heart failure (73.9%), acute infections (42%), cerebrovascular disease (11.6%), chronic kidney disease (10.1%), anemia (8.7%), type 2 Diabetes Mellitus (7.2%) and Hyperthyroid disease (2.9%). The most common (39.1%) antiarrhytmic used was combination of bisoprolol and digoxin. In-hospital all-cause mortality rate was 15.9%
Seluang Fish (Rasbora sp.) Oil Improves Interleukin-17 Levels and Disease Activity in Rheumatoid Arthritis
No full textBACKGROUND: Vitamin D has a role in downregulating the proinflammatory cytokines as well as promoting the antiinflammatory pathway in rheumatoid arthritis (RA). Seluang fish (Rasbora sp.) has potency as a new source of vitamin D. Previous study had proven Seluang fish oil efficacy in systemic lupus erythematosus. However, there are no trials that prove its efficacy in RA yet. Hence, this study was conducted to find out the ability of Seluang fish oil to improve proinflammatory cytokines, vitamin D levels, and disease activity in RA.METHODS: A clinical trial with a randomized and double-blind method was done in two groups, each one consisting of 17 RA subjects. One group was given 500 mL of a Seluang fish oil capsule (contains 665 IU cholecalciferol), while the other group was given a placebo daily, for 12 consecutive weeks. Measurements of the RA disease activity score 28 erythrocyte sedimentation rate (DAS28-ESR) and DAS28 C-reactive protein (DAS28-CRP), as well as measurement of interleukin (IL)-6, IL-17, and vitamin D levels by using immunoassay method were performed before and after the supplementation.RESULTS: Significant alterations in the lower levels of IL-17 were observed in the Seluang fish oil group (p=0.031), but not in the placebo group (p=0.320). Reduction of DAS28-ESR (p=0.000) and DAS28-CRP (p=0.000) score demonstrated that the Seluang fish oil supplementation was useful in reducing RA disease activity. No significant shift was observed in either vitamin D (p=0.967) or IL-6 levels (p=0.076) after Seluang Fish Oil supplementation.CONCLUSION: Seluang fish oil is effective in lowering IL-17 levels, DAS28-ESR, and DAS28-CRP, but not in improving vitamin D level or lowering IL-6 level in RA patients.KEYWORDS: rheumatoid arthritis, seluang fish oil, interleukin-6, interleukin-17, vitamin D, DAS2
JURIDICAL ANALYSIS OF THE LEGAL PROTECTION OF ADOPTED CHILDREN AGAINST DIVORCE OF ADOPTIVE PARENTS
No full textThe purpose of this journal is to find out how the legal consequences of child adoption and the legal protection of an adopted child in Mahkmah Decision 1149 / Pdt. Lmg To answer the problem studied, the author uses a normative type of research and the approach used in this research is a statutory approach. Based on the results of the study that the appointment of a child who is not legalized by a court decision has legal consequences, the legal relationship between the adopted child and his adoptive parents does not occur, which means that if in the future there is a problem or dispute, each party (in this case the adoptive parents and the adopted child) cannot sue each other before the Court, so the rights and obligations of each party cannot be demanded to the Court, and several other legal consequences. For the issue of protection, the adopted child is entitled to legal status and this is evidenced by a court decision that legally states that the appointment of a child has occurred and is valid in the eyes of the law
