1,721,001 research outputs found
Use of statins in patients with peripheral artery disease
No full textAtherosclerotic peripheral artery disease (PAD) is a growing health issue that affects more than 200 million individuals worldwide, conferring a high risk of cardiovascular events and death. In spite of its high prevalence, PAD has often been neglected in the past and the heightened cardiovascular risk of patients with PAD has been consistently under-recognized by practitioners. Considering that an integrated approach to reduce cardiovascular events and lower limb complications is necessary in this setting, statins represent the cornerstone of therapy as reported by current American and European guidelines. Literature has extensive data about the importance of lipid-lowering therapy in patients with PAD demonstrating that statins reduce symptoms, cardiovascular events and mortality. Despite data extrapolated from many studies on coronary artery diseases, moderate-dose statin therapy seems to be safe, and the minor risks posed in terms of myopathy-related symptoms are greatly outweighed by benefits. Other lipid-lowering drugs did not show the same results in terms of outcome and they should not be considered as first line therapy in these patients. The role of anti-PCSK9 inhibitors is emerging in the literature but further data are necessary to understand their superiority over statins
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The role of molecular gas in the nuclear regions of IRAS 00183-7111: ALMA and X-ray investigations of an ultraluminous infrared galaxy
No full textAims. We present a multi-frequency study of the ultraluminous infrared galaxy (ULIRG) IRAS 00183-7111 (z = 0.327), selected from the Spoon diagnostic diagram as a highly obscured active galactic nucleus (AGN) candidate. ALMA millimetre and X-ray observations are used; the main aim is to verify at what level the molecular gas, traced by the CO, may be responsible for the obscuration observed at X-ray energies. Theory and observations both suggest that galaxy-scale absorption may play a role in the AGN obscuration at intermediate (i.e. Compton-thin) column densities. Methods. We calibrated and analysed ALMA archival Cycle 0 data in two bands (Bands 3 and 6). The X-ray properties of IRAS 00183-7111 were studied by reducing and analysing separately archival Chandra and XMM-Newton data; recently acquired NuSTAR spectra were first examined individually and then added to the Chandra and XMM spectra for the broad-band (0.5 - 24 keV, observed frame) analysis. Results. We derived a molecular gas column density of (8.0 ± 0.9) × 1021 cm-2 from the ALMA CO(1-0) detection, while the best-fit column density of cold gas obtained from X-ray spectral fitting is 6.8-1.5+2.1×1022 cm-. The two quantities suggest that the molecular gas may contribute only a fraction of the AGN obscuration; however, the link between them is not straightforward. The nuclear regions of IRAS 00183-7111 are likely stratified into different layers of matter: one inner and highly ionized by the strong radiation field of the AGN (as inferred from the high-ionization iron line found in the X-ray spectra), and one outer and colder, extending more than 5 kpc from the nucleus (as traced by the molecular gas observed with ALMA). The molecular gas regions also give rise to a vigorous starburst with SFR ∼260 ± 28 Mo yr-1. The complexity of this nuclear environment makes it difficult to identify the origin of the AGN obscuration given the quality of the data currently available. Higher resolution observations in the millimetre regime are needed to deeply investigate this issue
Management of direct oral anticoagulants in patients with atrial fibrillation undergoing cardioversion
Full text linkAtrial fibrillation the most common cardiac arrhythmia. Its incidence rises steadily with each decade, becoming a real "epidemic phenomenon". Cardioversion is defined as a rhythm control strategy which, if successful, restores normal sinus rhythm. This, whether obtained with synchronized shock or with drugs, involves a periprocedural risk of stroke and systemic embolism which is reduced by adequate anticoagulant therapy in the weeks before or by the exclusion of left atrial thrombi. Direct oral anticoagulants are safe, manageable, and provide rapid onset of oral anticoagulation; they are an important alternative to heparin/warfarin from all points of view, with a considerable reduction in bleedings and increase in the safety and quality of life of patients
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Reverse remodeling and arrhythmic burden reduction in a patient with an implantable cardioverter defibrillator treated with sacubitril/valsartan: Case report
Full text linkSacubitril/valsartan has been shown to reduce cardiovascular mortality and hospitalizations in patients with HFrEF when compared to enalapril. There are also some evidences of its potential antiarrhythmic effects. We present a report where we found a relation between reverse ventricular remodeling and arrhythmic reduction in a patient treated with sacubitril/valsartan
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