9 research outputs found
Catalog of Quality Problems in Data, Data Models and Data Transformations
No full textThis catalogue describes quality problems in research data that are focussed on material cultural objects, corresponding data models and data transformations. It was created within the KONDA research project. This catalogue aims to elicit requirements for a generic quality management process for research data through the exchange with the community. The catalogue is the result of qualitative interviews and a workshop with experts on cultural heritage data. Within the catalogue, each quality problem is described through a structured profile, including aspects such as the affected quality dimensions, examples, causes and ideas on improvement
Implementing a Sustainability Agenda at Göttingen University Library
No full textIn 2020, UNESCO launched its programme, Education for Sustainable Development: A Roadmap (2020), and emphasised the pivotal role of education as a key enabler for the successful attainment of all of the United Nations Sustainable Development Goals (SDGs) (United Nations n.d.a). Germany has a national plan for implementation of ESD through UNESCO’s Deutsche UNESCO-Kommission/German Commission for UNESCO. Libraries are crucial to the realisation of the SDGs because they provide public access to information, preserve information to ensure ongoing and sustainable access, and help people to develop the capacity to use information effectively. However, libraries can also inspire sustainable awareness and individ-ual responsibility in the community through practical examples of their own. The Niedersächsische Staats- und Universitätsbibliothek Göttingen (SUB Göttingen)/ Göttingen State and University Library plays a part in implementing Germany’s ESD national plan and strives to improve its environmental performance by engaging in its own projects to diminish its environmental footprint and create awareness about the importance of the SDGs amongst library users and employees. Library-led initiatives lend credibility to the University’s and the region’s commitment to ESD and communicate values, goals and ongoing efforts towards sustainability. This chapter provides insights into the initiatives undertaken, outlines the related processes and challenges faced, and presents the lessons learned. The learnings have been an important part of the process and illustrate the necessary adaptation to internal structural developments and the positive impact of sustainability activ-ities. ESD extends beyond theoretical knowledge and encourages the incorporation of hands-on experiences that illustrate sustainable practices and the relationship to community learning
Śmierć Zygmunta Weidlinga (z wprowadzeniem Konrada Matyjaszka)
No full textIn this testimony, Ewa Weinberg describes the circumstances of the death of Zygmunt Weidling, a physician and her close relative. He died in the summer of 1942 in Soviet Uzbekistan when he tried to obtain permission for his family to join an evacuation transport organised by the Polish Armed Forces in the USSR (General Anders’s Army); he was denied due to the antisemitic policyof the Army Staff. The author also describes her family’s living conditions in Samarkand during the war. Her text is a testimony of a Holocaust survivor and a commemoration of Zygmunt Weidling.Świadectwo Ewy Weinberg opisuje okoliczności śmierci Zygmunta Weidlinga, lekarza i bliskiego krewnego autorki, który zmarł latem 1942 roku w radzieckim Uzbekistanie podczas nieudanej próby dołączenia swojej rodziny do transportu ewakuacyjnego organizowanego przez Polskie Siły Zbrojne (armię gen. Władysława Andersa) w ZSRR, czego mu odmówiono na skutek antysemickiej polityki sztabu. Autorka opisuje warunki życia swojej rodziny w Samarkandzie podczas wojny. Tekst jest świadectwem osoby ocalałej z Zagłady i stanowi upamiętnienie Zygmunta Weidlinga
Von der Leitlinie zur Praxis: Nachhaltigkeit an der SUB Göttingen
No full textDie Niedersächsische Staats- und Universitätsbibliothek Göttingen (SUB Göttingen) setzt sich zum Ziel, die 2015 von den Vereinten Nationen verabschiedeten Globalen Ziele einer nachhaltigen Entwicklung im Rahmen des eigenen Verantwortungsbereichs umzusetzen. Im September 2023 hat sie eine eigene Nachhaltigkeitsleitlinie verabschiedet. Ziel ist es, die SUB Göttingen in all ihren Facetten – von den Geschäftsprozessen im und rund um den Bibliotheksalltag bis hin zur technischen Infrastruktur – nachhaltiger und damit auch zukunftsfähiger zu gestalten. Die Arbeitsgemeinschaft Nachhaltigkeit (AG NH) der SUB Göttingen ist in diesem Zusammenhang als Informations- und Arbeitsgruppe aktiv. Der Bericht schildert am Beispiel des Projektes "Staudenbeet" die Erfahrungen mit der praktischen Umsetzung der Leitlinie und welche Erkenntnisse hierbei gewonnen wurden
Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D
No full textReciprocal mechanical interactions between cells and the extracellular matrix (ECM) are thought to play important instructive roles in branching morphogenesis. However, most studies to date have failed to characterize these interactions on a length scale relevant to cells, especially in three-dimensional (3D) matrices. Here we utilized two complementary methods, spatio-temporal image correlation spectroscopy (STICS) and laser optical tweezers-based active microrheology (AMR), to quantify endothelial cell (EC)-mediated deformations of individual ECM elements and the local ECM mechanical properties, respectively, during the process of capillary morphogenesis in a 3D cell culture model. In experiments in which the ECM density was systematically varied, STICS revealed that the rate at which ECs deformed individual ECM fibers on the microscale positively correlated with capillary sprouting on the macroscale. ECs expressing constitutively active V14-RhoA displaced individual matrix fibers at significantly faster rates and displayed enhanced capillary sprouting relative to wild-type cells, while those expressing dominant-negative N19-RhoA behaved in an opposite fashion. In parallel, AMR revealed a local stiffening of the ECM proximal to the tips of sprouting ECs. By quantifying the dynamic physical properties of the cell-ECM interface in both space and time, we identified a correlation linking ECM deformation rates and local ECM stiffening at the microscale with capillary morphogenesis at the macroscale
Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D.
No full textA Bioenergetics Systems Evaluation of Ketogenic Diet Liver Effects
No full textKetogenic diets induce hepatocyte fatty acid oxidation and ketone body production. To further evaluate how ketogenic diets affect hepatocyte bioenergetic infrastructure, we analyzed livers from C57Bl/6J male mice maintained for one month on a ketogenic or standard chow diet. Compared to the standard diet, the ketogenic diet increased cytosolic and mitochondrial protein acetylation and also altered protein succinylation patterns. SIRT3 protein decreased while SIRT5 protein increased, and gluconeogenesis, oxidative phosphorylation, and mitochondrial biogenesis pathway proteins were variably and likely strategically altered. The pattern of changes observed can be used to inform a broader systems overview of how ketogenic diets affect liver bioenergetics.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
The use of mobile phones and the risk of brain tumors among children and adolescents
No full textMobile phones experienced a steep rise in popularity among children and adolescents during the last decade. The increase in popularity has been reflected in both increased ownership and increased usage of mobile phones. Most children start to use mobile phones when they are around 9–10 years old, but usage before school age is not uncommon. The increase in mobile phone use has raised concerns about possible adverse health effects. Brain tumors have been a main concern because the brain absorbs most of the radio frequency energy emitted by mobile phones during calls. In addition, it has been hypothesized that children may be more vulnerable to radio frequency electromagnetic fields (RF-EMFs) because their nervous system is developing, their brain tissue is more conductive than that of adults, and RF-EMFs penetrate in to regions that are deeper in their brains. Radio frequency radiation emitted by mobile phones has insufficient energy to directly damage the DNA and the only known effect of RF-EMFs is heating of the tissue. Studies about mobile phone use and brain tumor risk among adults have shown no increased risk for regular users but have been inconclusive regarding long-term (≥10 years) and heavy mobile phone use. The largest case-control study so far, INTERPHONE, found an increased risk for glioma among heavy users (≥1640 lifetime calls). Another study from a Swedish research group reported a five-fold increased risk for astrocytoma for adults who first used mobile phones before the age of 20. No study has addressed the association between mobile phone use and brain tumor risk among children and adolescents so far. The goal of this thesis was to assess whether there is a relationship between mobile phone use and brain tumor risk among children and adolescents or not. In 2006, we set up CEFALO, an international case-control study about the relationship between mobile phone use and brain tumor risk in children and adolescents aged 7–19 years. CEFALO was performed in Denmark, Sweden, Norway, and Switzerland. The study period ranged from 2004 through 2008. Children and adolescents of age 7–19 years who were diagnosed during the study period with a primary brain tumor were eligible. For each case patient, we selected two healthy controls matched by age, sex and geographical region of residence using population registries. Exposure data was collected by face to face interviews with the study participants accompanied by at least one parent. Risk estimates for brain tumors were calculated for various exposure surrogates. We also examined the gender and age-adjusted brain tumor incidence rates among Swedish children and adolescents aged 5–19 years from 1990 to 2008 including hypothetical incidence rate trends based on the risk estimates found in our analyses. Lastly, we compared the self-reported amount of mobile phone use with objectively recorded data by network operators. Regular users of mobile phones were not statistically significantly more likely to have been diagnosed with brain tumors compared with non-regular users (OR=1.36, 95%-CI: 0.92 to 2.02). No clear exposure-response relationship was observed for any exposure surrogate. Moreover, no exposure-response relationship was seen in terms of localization of the tumor. For the study participants for whom operator-recorded data were available, we found a statistically significantly increased risk among users with more than 2.8 years since the start of the first subscription (OR=2.15). The odds ratio for brain tumor risk among ipsilateral regular users of mobile phones was not higher than the odds ratio of contralateral regular users. The risk estimate of 2.15 after 3 years of regular mobile phone use is incompatible with the stable (or even downward) incidence trends observed among Swedish children and adolescents aged 5–19 years from 1990 to 2008. This indicates that short-term use of mobile phones does not cause brain tumors in children and adolescents. In the validation study, cases overestimated their cumulative number of calls by 9% on average and controls by 34%. Cases also overestimated their cumulative duration of calls by 52% on average and controls by 163%. We found little evidence for differential recall errors. CEFALO is the first study to investigate the relationship between mobile phone use and brain tumor risk in children and adolescents. We found no consistent evidence for a causal association between short-term mobile phone use and brain tumor risk among children and adolescents. The lack of an exposure-response relationship either in terms of the amount of mobile phone use or by localization of the brain tumor argues against a causal relationship. These findings are corroborated by the fact that brain tumor incidence rates among children and adolescents have not increased in many countries in recent times. We cannot, however, exclude the possibility of a small increase in brain tumor risk due to mobile phone use. As we found that self-reported mobile phone use is affected with large random and some systematic recall errors, we emphasize the importance of future studies with objective exposure assessment or the use of prospectively collected exposure data. We also recommend the monitoring of time trends in brain tumor incidence rates as increased risks should be reflected in future brain tumor incidence rate trends
