358 research outputs found
Correction: Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
No full textNature Communications 8: Article number: 15132 (2017); Published: 2 May 2017; Updated: 6 February 2018 Michel Goedert, who developed the Thy1-P301S transgenic mouse, was inadvertently omitted from the Acknowledgments section of this Article. The Acknowledgements should have included the following: ‘We thank Michel Goedert for providing the Thy1-P301S transgenic mouse that was used in this study.</jats:p
The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons
No full textFrontotemporal lobar degeneration (FTLD) is the one of the most frequent neurodegenerative disorders characterized by behavioral and executive impairment, language disorders and motor dysfunction. Hereditary forms of FTLD are frequently reported and about 20-30% of cases exhibit an autosomal dominant transmission. Microtubule associate protein tau (MAPT) gene mutations are associated with early onset FTLD. Here we have identified a new MAPT mutation on exon 10 that alters both the protein function and the RNA alternative splicing. Biochemical and neuropathological studies indicate a high pathogenicity of this new MAPT mutation. Moreover induced neurons transdifferentiated from patient skin-derived fibroblasts and carrying the new MAPT mutation express both 3R and 4R tau isoforms differently from those obtained from embryonic fibroblasts which express only 3R tau isoform indicating that they are not mature neurons
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology
No full textFunding Information: We thank Michel Goedert for the MAPTP301S mouse and Nathaniel Heintz for the Aldh1l1_eGFP-RPL10a mouse. This work was funded by the UK Dementia Research Institute (G.E.H., S.C.) which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society, and Alzheimer’s Research UK, the European Research Council (ERC) under the EU’s Horizon 2020 research and innovation programme (Grant No. 681181, T.S.J.) and grant NIH P50 AG033514 (Project 1, J.A.J.).Peer reviewe
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