102,437 research outputs found
Finite phylogenetic complexity and combinatorics of tables
No full textIn algebraic statistics, Jukes–Cantor and Kimura models are of great importance. Sturmfels and Sullivant generalized these models by associating to any finite abelian group G a family of toric varieties X(G, K1,n). We investigate the generators of their ideals. We show that for any finite abelian group G there exists a constant φ, depending only on G, such that the ideals of X (G, K1,n) are generated in degree at most
DS_10.1177_0022034519855348 – Supplemental material for Dietary Nitrite Drives Disease Outcomes in Oral Polymicrobial Infections
No full textSupplemental material, DS_10.1177_0022034519855348 for Dietary Nitrite Drives Disease Outcomes in Oral Polymicrobial Infections by J. Scoffield, S. Michalek, G. Harber, P. Eipers, C. Morrow and H. Wu in Journal of Dental Research</p
Who is connected with whom? A Social network analysis of institutional interactions in the European CCA and DRR landscape
No full textCommunication and collaboration are critical for designing and implementing responses to climate change impacts and related disasters. This acknowledgement has increased interest in understanding social and institutional networks for climate change adaptation (CCA) and disaster risk reduction (DRR). In this study, we used Social Network Analysis (SNA) to explore institutional interactions within and across the communities of the aforementioned domains in Europe. Firstly, we investigated the type and intensity of interactions. We calculated SNA metrics to assess the roles of different actors and applied cluster analysis to identify actors with similar patterns of connections. SNA showed that communication is often more intensive within the two communities, while collaboration is frequent around topics related to both CCA and DRR. Cluster analysis revealed that actors tied with DRR were more closely connected, while actors tied with CCA and those with mixed connections showed no obvious clustering affnity. The European Climate Adaptation Platform, Climate-ADAPT, had the highest value for various SNA metrics, reflecting its popularity in the network and its potential for enhancing interactions among its actors. Finally, SNA was complemented by qualitative interviews, which emphasised the importance of connecting CCA and DRR in organisational mission and vision statements
Low degree equations for phylogenetic group-based models
No full textMotivated by phylogenetics, our aim is to obtain a system of low degree equations that define a phylogenetic variety on an open set containing the biologically meaningful points. In this paper we consider phylogenetic varieties defined via group-based models. For any finite abelian group G , we provide an explicit construction of codimX polynomial equations (phylogenetic invariants) of degree at most |G| that define the variety X on a Zariski open set U . The set U contains all biologically meaningful points when G is the group of the Kimura 3-parameter model. In particular, our main result confirms (Michalek, Toric varieties: phylogenetics and derived categories, PhD thesis, Conjecture 7.9, 2012) and, on the set U , Conjectures 29 and 30 of Sturmfels and Sullivant (J Comput Biol 12:204–228, 2005).Peer ReviewedPostprint (published version
Low degree equations for phylogenetic group-based models
No full textMotivated by phylogenetics, our aim is to obtain a system of low degree equations that define a phylogenetic variety on an open set containing the biologically meaningful points. In this paper we consider phylogenetic varieties defined via group-based models. For any finite abelian group G , we provide an explicit construction of codimX polynomial equations (phylogenetic invariants) of degree at most |G| that define the variety X on a Zariski open set U . The set U contains all biologically meaningful points when G is the group of the Kimura 3-parameter model. In particular, our main result confirms (Michalek, Toric varieties: phylogenetics and derived categories, PhD thesis, Conjecture 7.9, 2012) and, on the set U , Conjectures 29 and 30 of Sturmfels and Sullivant (J Comput Biol 12:204–228, 2005).Peer Reviewe
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
Regulators of G protein signalling proteins in the human myometrium
No full textThe contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and leading to changes in the activity of effector proteins responsible for bringing about the response. G proteins can interact with multiple receptors and many different effectors and are key
players in the response. Regulators of G protein signalling (RGS) proteins are GTPase activating proteins for heterotrimeric G proteins and help terminate the signal. Little is known about the function of RGS proteins in human myometrium and we have therefore analysed transcript levels for RGS proteins at various stages of pregnancy (non-pregnant, preterm, term non-labouring, term labouring). RGS2 and RGS5 were the most abundantly expressed isolates in each of the patient groups. The levels of RGS4 and RGS16 (and to a lesser extent RGS2 and RGS14) increased in term labouring samples relative to the other groups. Yeast two-hybrid analysis and co-immunoprecipitation in myometrial cells revealed that both RGS2 and RGS5 interact directly with the cytoplasmic tail of the oxytocin receptor, suggesting they might help regulate signalling through this receptor.
Key words: G protein-coupled receptors; labour; myometrium; RGS protein
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