109,987 research outputs found
Freundschaftliche Zuschrift an diejenigen, mit welchen ich in Ansehung der Beichte in näherer Verbindung stehe / von Prof. H. E. Güte, Oberdiakonus zu St. Ulrich
No full textAutopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Halle, gedruckt bey Friedr. Wilh. Michaelis. - Erscheinungsjahr nach Datierung am Textend
Optimal design for goodness-of-fit of the Michaelis-Menten enzyme kinetic function
No full textWe construct efficient designs for the Michaelis-Menten enzyme kinetic model capable of checking model assumption. An extended model, called EMAX model is also considered for this purpose. This model is widely used in pharmacokinetics and reduces to the Michaelis- Menten model for a specific choice of the parameter setting. Our strategy is to find efficient designs for estimating the parameters in the EMAX model and at the same time test the validity of the Michaelis-Menten model against the EMAX model by maximizing a minimum of the D- or D1-efficiencies taken over a range of values for the nonlinear parameters. In addition, we show that the designs obtained from maximizing the D-efficiencies are (i) efficient for estimating parameters in the EMAX model or the Michaelis-Menten model, (ii) efficient for testing the Michaelis-Menten model against the EMAX model and (iii) robust with respect to misspecification of the unknown parameters. --Chebyshev polynomials,EMAX model,goodness of fit test,locally D-optimal design,robust optimal design
De Morbo Dysenterico / Consensv Gratiosae Facvltatis Medicae In Regia Fridericiana Praeside D. Philippo Adolpho Boehmero Facvltatis Medicae Seniore Et H. T. Decano Pro Gradv Doctoris Medicinae Solemniter Conseqvendo Die VIII. M. Octobr. MDCCLXXXII Pvblice Disseret Avctor Ferdinandvs Fridericvs Walther Glogavia-Silesivs
No full textHalle, Univ., Med. Diss., 1782Autopsie nach Exemplar der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Halae Magdebvrgicae, Litteris Frid. Wilh. Michaelis
Acoustic voice analysis by means of the hoarseness diagram
No full textThe hoarseness diagram (Michaelis, Frohlich, & Strube, 1998a) has been proposed as a new approach to describe different acoustic properties of voices. To test its performance in the analysis of pathologically disturbed and normal voices five requirements are suggested that should be met by any acoustic voice-analysis protocol to be used in voice research and clinical practice. The hoarseness diagram is then tested with regard to these requirements. Individual voices are Found to show a satisfactory localization in the diagram. Aspects of stationarity are discussed in the context of four case studies. The different cases illustrate that changes in the acoustic analysis results are observed if the voice-generation conditions change, whereas results are stationary if phonation conditions do not change. Different pathological voice groups defined on grounds of the specific phonation mechanism are found to map to specific regions of the hoarseness diagram, with differences between group locations being significant. All results can be interpreted without exceptions if the two hoarseness diagram coordinates are taken to reflect the vibrational irregularity of the voice-generation mechanisms on the one side and the degree of closure of the vibrating structures on the other side. The hoarseness diagram and its underlying algorithms are thus shown to constitute a useful approach to acoustic voice analysis in research and clinical practice. The tests themselves demonstrate several application possibilities, including the quantitative monitoring of individual voices
Acoustic voice analysis by means of the hoarseness diagram
No full textThe hoarseness diagram (Michaelis, Frohlich, & Strube, 1998a) has been proposed as a new approach to describe different acoustic properties of voices. To test its performance in the analysis of pathologically disturbed and normal voices five requirements are suggested that should be met by any acoustic voice-analysis protocol to be used in voice research and clinical practice. The hoarseness diagram is then tested with regard to these requirements. Individual voices are Found to show a satisfactory localization in the diagram. Aspects of stationarity are discussed in the context of four case studies. The different cases illustrate that changes in the acoustic analysis results are observed if the voice-generation conditions change, whereas results are stationary if phonation conditions do not change. Different pathological voice groups defined on grounds of the specific phonation mechanism are found to map to specific regions of the hoarseness diagram, with differences between group locations being significant. All results can be interpreted without exceptions if the two hoarseness diagram coordinates are taken to reflect the vibrational irregularity of the voice-generation mechanisms on the one side and the degree of closure of the vibrating structures on the other side. The hoarseness diagram and its underlying algorithms are thus shown to constitute a useful approach to acoustic voice analysis in research and clinical practice. The tests themselves demonstrate several application possibilities, including the quantitative monitoring of individual voices
Zingen tegen de wind in. Kroniek van de Poëzie
No full textItem does not contain fulltextH. Michaelis Verzamelde gedichten : ,199
Personal Papers (MS 80-0002)
No full textLetter from Dr. Hildegard Michaelis to I. H. Kempner and Robert Lee Kempner thanking the Kempners for sending a check to help people in Hamburg that were affected by a flood
Michaelis-Menten enzyme kinetic parameters (mean ± SD) determined for cytochrome c reduction by recombinant POR-H1 and POR variants (H2, H3 and H4)<sup>a</sup>.
No full textMichaelis-Menten enzyme kinetic parameters (mean ± SD) determined for cytochrome c reduction by recombinant POR-H1 and POR variants (H2, H3 and H4)a.</p
Astronomy camps as a long-term, successful engagement practice
No full textScience camps are one of the oldest forms of modern public engagement, and yet they are often overlooked. In this talk we will make the case for astronomy camps in particular, as strong evidence for long-term and successful impact. The longest running astronomy camp - the International Astronomical Youth Camp (IAYC) - has been around for more than 50 years, and has since effectively engaged and positively influenced the lives of 1000s of participants from around the world. The IAYC is a 3-week camp which uses astronomy as a medium for scientific inquiry. Participants are 16-24 years old and come from a great range of backgrounds - academically and culturally - and ~80% have never studied astronomy before attending. During the camp the participants work on a project of their choosing, and they are guided by their working group leaders through the research process. At the end of the camp, they write up their findings (using LaTeX), which get published in a report book. To clearly understand the camp's impact, we conducted a survey which was completed by ~315 people from over 50 different nationalities, representing every year of the IAYC. We find that many participants go on to pursuing careers in STEM: 25% are currently studying or working in astronomy-related roles, and ~45% have pursued other fields in STEM.The survey results clearly reinforce the benefits of a camp like the IAYC. Via informal learning, young adults improve their understanding and appreciation of science and the scientific method, and often go on to implement the skills they have learned in the wider world. Thus, these findings can be used to support our case for astronomy and its relevance to society
SIM - simultaneous inverse filtering and matching of a glottal flow model for acoustic speech signals
No full textA new method "simultaneous inverse filtering and model matching" (SIM) is proposed that allows one to calculate voice source measures without any user interaction. It is based on the discrete all-pole modeling (DAP) technique for inverse filtering (IF), which is modified to include a model of the glottal flow as integral part [LF model, Fant ct al., STL-QPSR (Stockholm) 4/1985, 1-13 (1986)]. As the correct LF parameters are initially unknown, they are estimated in an iterative procedure using multi-dimensional optimization techniques that are initialized according to the results of an exhaustive search. The error criteria applied reflect how well the IF is performed after the spectral contribution of the glottal flow has been removed. The resulting optimal LF parameter constellation serves as the basis to calculate 11 voice source measures. The performance was evaluated using synthesized signals and recordings of natural utterances. For the synthesized signals, the accuracy to reproduce the original parameters was high (correlations exceeding 0.88) for measures where the starting point of the glottal cycle did not enter explicitly. Errors were smaller compared to conventional estimation methods where the measures were estimated from the IF signal. The analysis of natural utterances indicates that problems still exist with regard to robustness, but that under advantageous conditions the open quotient, the speed quotient, the closing quotient, the parabolic spectral parameter, and the negative peak amplitude of the glottal flow derivative can indeed be determined automatically by the SIM method. (C) 2001 Acoustical Society of America
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