12 research outputs found
Inferences on Lung Cancer Mortality Rates Based on Reference Priors Under Partial Ordering
No full text
Cognitive Function and Behavior of Children With Adenotonsillar Hypertrophy Suspected of Having Obstructive Sleep-Disordered Breathing
No full textA proposta de reforma do ensino jurídico em Chaïm Perelman e reflexões sobre sua aplicação no Brasil
No full textO objetivo do presente trabalho é examinar o pensamento de Chaïm Perelman a partir de sua proposta de alteração do ensino jurídico belga e, por conseguinte, refletir sobre a sua viabilidade no Brasil. Em um relatório enviado a seminário ocorrido em Peruggia, na Itália, em 1973, Perelman retoma seu pensamento acerca do estudo da retórica aplicada ao direito e propõe a revisão do ensino do direito na Bélgica. No presente trabalho, busca-se compreender a proposta dentro do pensamento do autor e também compreender as criticas que este realiza à lógica aplicada pela Escola da Exegese, pelo positivismo jurídico e pelo Jusnaturalismo Dogmático. Para tanto, retoma-se o caminho histórico da retórica e também das doutrinas racional-dedutivas no estudo do direito.
Com a finalidade de permitir a transposição das idéias de Perelman para o Brasil, traça-se um panorama das normas que orientam o ensino jurídico brasileiro atual e passa-se, por fim, às reflexões acerca da conveniência ou possibilidade de aplicação da reforma proposta pelo autor ao sistema brasileiro.
Conclui-se, ao final, que o estudo da retórica e da argumentação tem muito a contribuir com a perspectiva atual do ensino jurídico brasileiroThe objectives of the present essay is to examine the thought of Chaim Perelman studying his proposal of modification of the Belgian law education and, therefore, reflect on its viability in Brazil. In a report sent to the seminar held in Perugia, Italy, in 1973, Perelman takes over his thoughts on the study of rhetoric applied to law and proposes the revision of its teaching system in Belgium. In this exposition, we seek to understand the proposal within the author's thought and also comprehend his critics to the logic applied by the Exegesis School, by the legal positivism and natural law dogmatic. For this, we reconsider the historic journey of rhetoric and also of the rational-deductive doctrine in the study of law. In order to allow the transposition of Perelman ideas to Brazil, a picture of the standards that guide Brazil`s current law education is drawn and, at last, we go through ideas about the conviniency and/or possibility of implementing the reform proposed by the author in the Brazilian system. We conclude, finally, that the study of rhetoric and argumentation has much to contribute to the current perspective of law education in Brazi
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
No full textVariability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types. © 2021 The Author(s
Whole-genome sequencing reveals host factors underlying critical COVID-19
No full text: Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
No full textVariability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
No full textVariability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
