1,357,312 research outputs found
Antithrombotic drugs with adjuvant action against COVID-19
No full textWaiting for the vaccine and/or the best antiviral treatment for coronavirus infection disease 2019 (COVID-19), after its outbreak in China at the beginning of 2020 and its viral diffusion around the world in the following weeks, several drugs have been suggested for their potential adjuvant support against infection. Several drugs have been suggested to have a potential ancillary antiviral role. Circulating proteins, in particular proteases and peptidases regulated by drug functions, may interact with well-known drugs like anticoagulants, antihypertensives, antiserotoninergics, and so also with viral proteases. We here report a brief list of these drugs (i.e., heparinoids, flavonoids, antiplatelets, anticoagulants) that may interact with COVID-19
Can be Solanum lycopersicum L. cv ‘Micro-Tom’ a good candidate for growth in Space? Testing the effects of High-LET ionizing radiation on plant growth, photosynthesis and antioxidants
No full textThe possibility to cultivate plants in Space represents an ongoing challenge because in extraterrestrial environments, plant growth is controlled by factors, some of which are also acting on Earth (e.g. temperature, relative humidity, light) while others are peculiar such as altered gravity in addition to a profoundly different ionizing radiation (IR) field (De Micco et al., 2011). In particular, exposure to Space IR may determine several outcomes depending on the dose, radiation quality (high vs. low LET), exposure rate (acute vs. chronic), but also by the intrinsic characteristics of the organism, such as species, cultivars, developmental stage, structure of organs and tissues and genetic traits (De Micco et al., 2011). Generally, plant response to IR is manifestly dose-dependent with irreparable damage at high doses, sublethal consequences at intermediate levels and stimulatory effects at low dose (De Micco et al., 2011; Arena et al., 2014). In this study we explore the possibility that low doses of heavy ions, namely C ions at dose of 25 Gy delivered at seed stage, may exert beneficial effects on Solanum Lycopersicum L. cv ‘Micro-Tom’ on physiological, biochemical and anatomical traits, promoting the fruit ripening and quality. This would have important consequences in the view of its utilization on board of the Bioregenerative Life Support Systems (BLSSs) as food for crew. For this purpose, the plant life cycle from germination to fruit harvesting was monitored in terms of plant growth, photosynthetic efficiency, leaf anatomical traits and antioxidant production in leaf and fruits. The irradiation did not affect plant germination. Plants from irradiated seeds showed reduced height and a more compact size. The PSII quantum yield as well as the electron transport rate was promoted in irradiated compared to control plants. These data are consistent with a high level of D1 protein and photosynthetic pigment content in the leaves. As regards fruit, plants from irradiated seeds showed a significantly higher content of ascorbic acid, carotenoids and anthocyanins
Effects of tariffs and real exchange rates on job reallocation: evidence from Latin America
No full textOpenness to international competition can lead to enhanced resource allocation in the long-run. While factor reallocation is essential if net benefits are to be derived from trade liberalization, the process generates costs both for transitioning workers and for employers undergoing personnel turnover. Net welfare gains depend on adjustment costs. Understanding of these issues has been hampered by data limitations. In this paper, we overcome some of these limitations by using new, harmonized measures on job creation and destruction for a number of countries in Latin America. We use these new series to investigate the impact of the removal of protectionism on net employment and gross job reallocation in Latin America. We find a robust pattern showing that reductions in tariffs and exchange rate appreciations increase the pace of job reallocation within sectors. We also find, however, some evidence of declining net employment as trade exposure increases. For example, we find some evidence that in the wake of tariff reductions, there is lower net employment growth. <br/
Plant growth and reproduction in altered gravity. International conference Living the Space
No full textCorrection: Di Micco et al. Clinical Differences between COVID-19 and a COVID-like Syndrome. J. Clin. Med. 2021, 10, 2519.
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Structural MRI in Idiopathic Parkinson's Disease
No full textAmong modern neuroimaging modalities, magnetic resonance imaging (MRI) is a widely available, non-invasive, and cost-effective method to detect structural and functional abnormalities related to neurodegenerative disorders. In the last decades, MRI have been widely implemented to support PD diagnosis as well as to provide further insights into motor and non-motor symptoms pathophysiology, complications and treatment-related effects. Different aspects of the brain morphology and function may be derived from a single scan, by applying different analytic approaches. Biomarkers of neurodegeneration as well as tissue microstructural changes may be extracted from structural MRI techniques. In this chapter, we analyze the role of structural imaging to differentiate PD patients from controls and to define neural substrates of motor and non-motor PD symptoms. Evidence collected in the premotor PD phase will be also critically discussed. White matter as well as gray matter integrity imaging studies has been reviewed, aiming to highlight points of strength and limits to their potential application in clinical settings
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