1,720,959 research outputs found
Antacids in gastric ulcer treatment: evidence of cytoprotection.
No full textAntacids are more effective than placebo, and their efficacy is comparable to that of H2-blockers in gastric ulcer healing even though the healing time is about 2 weeks longer than with H2-blockers. Some observations in animals and healthy subjects may indicate that antacids (particularly those containing aluminium hydroxide) have a protective effect on the gastroduodenal mucosa in that they increase the production of prostanoids and sulphhydryl-containing compounds. We showed that 10 days' treatment with high-dose antacids (Maalox TC) is able to increase 6-keto-PGF1v production from cultured biopsy specimens of patients with gastric ulcer. These data could constitute a further indication in the treatment of peptic disease. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
SERUM BINDING ACYIVITY FOR PHSA DUE TO ANTIBODIES DETECTED BY ENZYME IMMUNOSORBENT ASSAY IN ACUTE AND CHRONIC TYPE B,A AND NANB VIRAL HEPATITIS
No full textPolymerized human serum albumin (pHSA) binding activity due to antibodies was evaluated by a sensitive and specific enzyme-linked immunosorbent assay (ELISA) in well characterized cases of acute (AVH) and chronic active (CAH) viral hepatitis. Moreover, hepatitis B virus (HBV) infection serum samples were tested for the presence of HBsAg-associated pHSA receptors detected by radioimmunoassay. Specificity of ELISA in detecting pHSA binding activity due to antibodies was assayed by testing IgG fractions from positive serum samples and purified HBsAg particles. A very high prevalence (mean = 87%) of antibody response to pHSA was detected in serum samples of patients with type B, A and post-transfusion non-A, non-B (NANB) AVH and CAH. IgM antibodies were found in 75% of type B AVH, in 77% of type A AVH and in none of the NANB cases at the onset of illness. In CAH, IgM antibodies were found in 37.5% of HBsAg-positive cases and in 44% of NANB cases. In HBV-related AVH and CAH no correlation was found between anti-pHSA antibodies and HBsAg-associated pHSA receptors or the HBeAg/anti-HBe status. The antibody response detected by ELISA showed a cross-reactivity with monomeric human albumin and heterologous polymeric and monomeric albumins. However, in HBV infection the antibody binding was significantly higher for pHSA than for monomeric human albumin or albumins from other species, thus suggesting that the antigenic sites of pHSA evoking the antibody response may differ in relation to the etiology of viral hepatitis
Clinical significance of antibodies to polymerized human albumin detected by enzyme-linked immunosorbent assay.
No full textSerum binding activity for polymerized human albumin due to antibodies detected by enzyme-linked immunosorbent assay in acute and chronic type B, A and NANB viral hepatitis.
No full textPersonalità, stress psicologico e attività natural killer: studio preliminare
No full textIn questo studio preliminare vengono riportati i risultati di una indagine effettuata su giovani adulti per valutare se una situazione di stress psicologico, quale un esame di profitto, si accompagna ad alterazioni nella funzionalità del sistema immunitario, in particolare nella attività citolitica delle cellule natural killer (NK). Circa 300 cadetti del primo anno di corso della Accademia Militare di Modena sono stati sottoposti a una valutazione psicometrica per quantificare i tratti d’ansia della personalità e, su questa base, sono stati selezionati due gruppi di soggetti collocati agli estremi delle scale di valutazione. L’attività delle cellule NK è stata misurata, utilizzando una nuova metodica messa a punto nei nostri laboratori, prima dell’esame e, per confronto, in una giornata “tipo” all’inizio dell’anno accademico. L’attività NK è risultata inferiore negli allievi con un elevato punteggio di ansia di tratto, rispetto a quelli con un basso punteggio, e in occasione dell’esame rispetto alla giornata di controllo. Inoltre l’attività NK correlava con il punteggio di un questionario somministrato prima dell’esame, tendente a valutare l’ansia legata a questo evento stressante. È infine emersa una interessante relazione tra ansietà, risposta immunitaria e caratteristiche antropometriche, in quanto l’indice di massa corporea degli allievi correlava positivamente con l’attività NK e negativamente con il punteggio dell’ansia di stato
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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