100,856 research outputs found
Surgical healthcare needs for transgender patients: surgeons’ perspectives
No full textHelena Gresty, Saiful Miah, Roland Morley Department of Urology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UKWe read with great interest the article by Dubin et al,1 who highlighted the specific healthcare needs and barriers the transgender population continues to face. Our department is the largest surgical provider in Europe for those transgender patients requiring male-to-female genital reconstruction surgery and would like to provide our unique perspective.2Authors’ replyShane D Morrison1 Samuel N Dubin2 Ian T Nolan2 1Division of Plastic Surgery, Department of Surgery, University of Washington School of Medicine, Seattle, WA, USA; 2New York University School of Medicine, New York, NY, USAWe thank Dr Miah et al for their insightful perspective on gender-minority healthcare education among surgical trainees in response to our article.1View the original paper by Dubin and colleagues
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
A new charging scheme for ATM based on QoS
No full textPhDNew services are emerging rapidly within the world of telecommunications. Charging
strategies that were appropriate for individual transfer capabilities are no longer appropriate
for an integrated broadband communications network. There is currently a range of
technologies (such as cable television, telephony and narrow band ISDN) for the different
services in use and a limited number of charging schemes are applicable for each of the
underlying technologies irrespective of the services used over it. Difficulties arise when a
wide range of services has to be supported on the same integrated technology such as
asynchronous transfer mode (ATM); in such cases the type of service in use and the impact
it has on the network becomes much more important. The subject of this thesis, therefore,
is the charging strategies for integrated broadband communications networks. That is, the
identification of the requirements associated with ATM charging schemes and the proposal
of a new approach to charging for ATM called the “quality of service based charging
scheme”.
Charging for ATM is influenced by three important components: the type and content of a
service being offered; the type of customer using the services; and the traffic characteristics
belonging to the application supporting the services. The first two issues will largely be
dependent on the business and regulatory requirements of the operators. The last item, and
an essential one for ATM, is the bridge between technology and business; how are the
resources used by a service quantified? Charging that is based on resource usage at the
network level was the prime focus of the research reported here.
With the proposed charging scheme, a distinction is first made between the four different
ATM transfer capabilities that will support various services and the different quality of
service requirements that may be applicable to each of them. Then, resources are
distributed among buffers set-up to support the combination of these transfer capabilities
and quality of services. The buffers are dimensioned according to the M/D/1/K and the
ND/D/1 queuing analysis to determine the buffer efficiency and quality of service
requirements. This dimensioning provides the basis for fixing the price per unit of resource
and time. The actual resource used by a connection is based on the volume of cells
transmitted or peak cell rate allocation in combination with traffic shapers if appropriate.
Shapers are also dimensioned using the quality of service parameters. Since the buffer
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efficiency is dependent on the quality of service requirements, users (customers) of ATM
networks buy quality of service. The actual price of a connection is further subjected to a
number of transformations based on the size of the resource purchased, the time of the day
at which a connection is made, and the geographical locality of the destination switch.
It is demonstrated that the proposed charging scheme meets all the requirements of
customers and of network operators. In addition the result of the comparison of the new
scheme with a number of existing, prominent, ATM charging schemes is presented,
showing that the performance of the proposed scheme is better in terms of meeting the
expectations of both the customers and the network operators
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
trans-(3S,5S,10R,12R)-1,8-Bis(2-cyanoethyl)-C-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraaza-cyclotetradecane
No full textThe structure determination of the tetraaza macrocyclic title compound, C24H46N6, shows that its molecule represents a meso-isomer; it occupies a special position about the crystallographic inversion centre. The pendent ethylcyano arms are oriented above and below the N4 plane and are directed away from the central cavity.Tapashi G. Roy, Saroj K. S. Hazari, Benu K. Dey, Hazarat A. Miah and Edward R. T. Tiekin
Wave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
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