52,438 research outputs found
Optimal H1N1 vaccination strategies based on self-interest versus group interest
No full textBackground\ud
Influenza vaccination is vital for reducing H1N1 infection-mediated morbidity and mortality. To reduce transmission and achieve herd immunity during the initial 2009-2010 pandemic season, the US Centers for Disease Control and Prevention (CDC) recommended that initial priority for H1N1 vaccines be given to individuals under age 25, as these individuals are more likely to spread influenza than older adults. However, due to significant delay in vaccine delivery for the H1N1 influenza pandemic, a large fraction of population was exposed to the H1N1 virus and thereby obtained immunity prior to the wide availability of vaccines. This exposure affects the spread of the disease and needs to be considered when prioritizing vaccine distribution.\ud
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Methods\ud
To determine optimal H1N1 vaccine distributions based on individual self-interest versus population interest, we constructed a game theoretical age-structured model of influenza transmission and considered the impact of delayed vaccination.\ud
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Results\ud
Our results indicate that if individuals decide to vaccinate according to self-interest, the resulting optimal vaccination strategy would prioritize adults of age 25 to 49 followed by either preschool-age children before the pandemic peak or older adults (age 50-64) at the pandemic peak. In contrast, the vaccine allocation strategy that is optimal for the population as a whole would prioritize individuals of ages 5 to 64 to curb a growing pandemic regardless of the timing of the vaccination program.\ud
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Conclusions\ud
Our results indicate that for a delayed vaccine distribution, the priorities that are optimal at a population level do not align with those that are optimal according to individual self-interest. Moreover, the discordance between the optimal vaccine distributions based on individual self-interest and those based on population interest is even more pronounced when vaccine availability is delayed. To determine optimal vaccine allocation for pandemic influenza, public health agencies need to consider both the changes in infection risks among age groups and expected patterns of adherence
Meyers (Birth, 1900-05-01)
No full textAddress: 1778 Powers1918/P.178/1900/M W/Russia/Russia/Dr. W. E. DeCourcyOriginal record filed in drawer labeled 'MEYER, G-MEYERS, D'
Meyers (Birth, 1904-07-12)
No full textAddress: Cinti. Hospital2986/P.152/1904/FW/Ky./Ky./Dr. A. VossOriginal record filed in drawer labeled 'MEYER, G-MEYERS, D'
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Meyers, Albert (Birth, 1901-04-30)
No full textAddress: 1060 Freeman147/Pg 114/1901/M W/Russia/Russia/Dr. S. P. HottendorfOriginal record filed in drawer labeled 'MEYER, G-MEYERS, D'
Meyers, Robert F. (Birth, 1900-05-08)
No full textAddress: 1410 Elder2220/P.184/1900/M W/Cinti/Cinti/Mrs. K. SperlOriginal record filed in drawer labeled 'MEYERS, D- MILLER, A'
Meyers, Charles John (Birth, 1903-05-29)
No full textAddress: 712 W. 6th1939/P.205/1903/MW/Ohio/Ohio/Dr. E. T. BehymerOriginal record filed in drawer labeled 'MEYER, G-MEYERS, D'
Meyers, John (Death, 1908-10-16)
No full textAddress: City Hosp- 1636 Westwood Ave.Age at death: 63 yrs249/Pg 122/1908/MW/Married/Indiana/David F. Gerbe, M. D./P. Rebold & Son/St. Jos. NewOriginal record filed in drawer labeled 'MEYERS, D- MILLER, A'
Meyers, Harry Joseph (Birth, 1887-10-03)
No full textAddress: 128 Baum5624/Pg.142/1887/W M/Am./Am./I. P. WattkerOriginal record filed in drawer labeled 'MEYERS, D- MILLER, A'
Meyers, Joseph (Birth, 1898-08-15)
No full textAddress: 723 W. 6th St.4352/P.124/1898/M W/Ky./Mrs. L. C. BircOriginal record filed in drawer labeled 'MEYERS, D- MILLER, A'
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