187 research outputs found
Der auff Göttliche Führung sehende Priester/ Wie solchen aus dem CXXIII. Psalm nach erhaltener rechtmäßigen Vocation zum Pastorat der Kirchen S. Ulrici in Halle und Scholarchat des dasigen Gymnasii. Am 4. Sonnt. nach den Fest der Erscheinung Christi 1708. Zum Beschluß seines neunjährigen Predigt-Ammts in der Kirche S.S. Petri und Pauli zu Goßlar bey volckreicher Versammlung in einer Abschieds-Predigt vorgestellet jetzo aber auff vielfältiges Verlangen und Anhalten zum Druck übergeben / Joh. Michael Heineccius, damahliger Prediger der Kirche zu S.S. Petri und Pauli
No full textEnthält Widmung an: "Der ... Frauen ... Catharinen Gertrud/ Verwittweten von Seidenstickerin ... Herrn Joh. Gottfried Rhesen ... Herrn Gottfried Brendecken ... Arend Wagner ... Conrad Arend Meyern ... Hans Henning Siemens ..."Enthält Beitrag von: "Joh. Gotofredus Rhese ... Gottfried Brendeken .... Arendt Wagner ... Conrad Arendt Meyer ... Hans Henning Siemens ..."Vorlageform der Veröffentlichungsangabe: Halle/ Verlegts Jobst Wetterkampf/ druckts Johann Montag. - Erscheinungsjahr nach Datierung im Titel bestimm
Aus der 'Unschuld des Werdens' heraus. Zu Jobst Tilmanns neueren Form-Findungen
No full textMeyer I. Aus der 'Unschuld des Werdens' heraus. Zu Jobst Tilmanns neueren Form-Findungen. In: Tholen C-D, ed. Jobst Tilmann, Trans. Herford; 2016: 48-54
Association of a polymorphism in the H6PD gene and basal cortisol secretion, body fat mass and leptin level (Assoziation eines Polymorphismus im H6PD Gen mit basaler Cortisolsekretion, Fettmasse und Leptinwerten)
No full textThe hypothalamus-pituitary-adrenal (HPA) axix is vital for an organism's response to physical or psychosocial stimulation. Chronic dysregulation of HPA axis activity is related to several psychiatric and psychosomatic disorders. Cortisol, the end product of this endocrine system, affects a multitude of systems in the body, including the HPA axis itself and it also has an influence on behavior. The intracellular availability of cortisol is crucial for the regulation of this endocrine system. The enzyme hexose-6-phosphat-dehydrogenase (H6PDH) affects cortisol availability via its influenec on 11?-hydroxysteroid dehydrogenase type I (11?-HSDI)-activity, which regenerates cortisol from inactive cortisone. 116 healthy males (33 monozygotic & 25 dizygotic twin pairs) were studied to estimate the association between a polymorphism in the exon 5 of the H6PD gene (R435Q, GA) and adrenocortical responses to psychosocial stress, basal salivary cortisol levels and body composition. Compared with subjects with the more frequent H6PD genotypers the homozygous AA-carriers displayed a significantly decreased cortisol awakening rise (CAR) as well as lower daytime cortisol levels. In response to stress, the AA-carriers exhibited a trend towards lower cortisol and ACH responses compared with GG- and GA-carriers. In addition, significantly higher levels of leptin and amount of body fat were observed in AA-carriers. We hypothesize that the R453Q polymorphism in the H6PD gene might influence intracellular cortisol availability and thus affect HPA axis regulation.<br/
Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning
No full textWorking memory deficits are found in different psychiatric populations and are most pronounced in schizophrenia. There is preliminary evidence from pharmacological studies that the verbal and visuospatial subcomponents of working memory are subject to differential neurotransmitter modulation. Here, we investigated the impact of well-known polymorphisms of the dopamine transporter gene (SLC6A3, DAT) and the catechol-O-methyl-transferase gene (COMT) as well as the serotonin transporter gene (SLC6A4, 5-HTT) on these specific working memory subcomponents in a mixed sample of patients and healthy individuals. Twenty healthy subjects and 80 patients diagnosed with schizophrenia, bipolar I disorder, or obsessive-compulsive disorder underwent genotyping for the DAT variable number of tandem repeats (VNTR), the COMT val/met-, and the 5-HTT promoter length polymorphism (5-HTTLPR) and neuropsychological testing using a battery of well-characterized, brain circuit-specific working memory tasks. DAT genotype revealed a significant and selective effect on visuospatial working memory, while there was no effect on verbal working memory functioning. 5-HTT genotype, by contrast, exerted a significant and selective effect on verbal working memory task performance. COMT genotype did not show any influence on either working memory domain. The results of the present study provide evidence for a differential impact of genetic polymorphisms of the dopaminergic and serotonergic systems on verbal and visuospatial working memory functioning. Together with prior evidence suggesting the existence of subgroups of schizophrenia patients exhibiting isolated deficits in only one working memory domain, this finding further supports the idea of endophenotypically and pathophysiologically distinct subgroups of schizophrenia with implications for personalized therapeutic approaches
Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance
No full textHyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis has been associated with the etiology of major depression. One of the factors underlying altered glucocorticoid signaling might be variability of the glucocorticoid receptor gene (GR, NR3C1). GR polymorphisms have been associated with variability in glucocorticoid sensitivity and endocrine responses to psychosocial stress. Furthermore, a common GR SNP (rs10482605), located in the promoter region, has been associated with major depression. We performed functional characterization of this SNP in vitro using a reporter gene assay under different stimulation conditions. Furthermore, we genotyped 219 subjects previously genotyped for four common GR SNPs to further characterize GR haplotype structure. The minor C allele of the rs10482605 SNP showed reduced transcriptional activity under unstimulated conditions and under different stimulation conditions in two brain derived cell lines. Linkage analyses revealed that the rs10482605 SNP is in high linkage disequilibrium with a A/G SNP in exon 9beta (rs6198), associated with relative glucocorticoid resistance and increased GRbeta mRNA stability. We provide evidence that two functional GR SNPs in linkage disequilibrium are responsible for both regulation of GR expression and mRNA stability. This newly characterized haplotype could increase the risk for the development of stress related disorders, including major depression
5-HTTLPR genotype influences amygdala volume
No full textFunctional imaging studies in healthy individuals revealed an association between 5-HTTLPR genotype and neuronal activity in the amygdala. The aim of this study was firstly to investigate a possible overall impact of the 5-HTTLPR on amygdala volume in patients with bipolar disorder and healthy individuals and secondly to test a diagnosis specific influence of the 5-HTTLPR on amygdala volume. We performed a region of interest analysis of amygdala volume in 37 patients with bipolar I disorder and 37 healthy control subjects. The 5-HTTLPR genotype of each proband was determined and the subjects were separated according to 5-HTTLPR genotype and for statistical analyses the groups SS and SL were combined and compared with the group LL. This study shows that carriers of the short allele (SL or SS) of the 5-HTTLPR polymorphism exhibit a relatively increased volume of the right amygdala compared to homozygous L-allele carriers irrespective of diagnosis status. However, further analyses with the factors genotype and diagnosis were not able to reproduce this result. The present findings are consistent with the view that the 5-HTTLPR polymorphism might modulate neuronal size or number in the amygdala. It would be worthwhile investigating the relationship between serotonin transporter function and amygdala function and volume in further studies
Der lange Abschied vom Bürgertum Joachim Fest und Wolf Jobst Siedler im Gespräch mit Frank A. Meyer
No full textAsset securitisation as a risk management and funding tool : what does it hold in store for SMES?
No full textThe following chapter critically surveys the attendant benefits and drawbacks of asset securitisation on both financial institutions and firms. It also elicits salient lessons to be learned about the securitisation of SME-related obligations from a cursory review of SME securitisation in Germany as a foray of asset securitisation in a bank-centred financial system paired with a strong presence of SMEs in industrial production. JEL Classification: D81, G15, M2
Association of DISC1 Genetic Variation with Intermediate Phenotypes in Neuroimaging: Replication and Further Extension
No full text- …
