262,232 research outputs found
I’m a lip-reading scientist: here’s how I can discuss science with you
No full textMeuthen D. I’m a lip-reading scientist: here’s how I can discuss science with you. Nature. 2022
76-year old patient with suspected but not confirmed “idiopathic myelofibrosis”
No full textFeld C, Spangenberger H, Böhm J, Meuthen D, Meuthen I. 76-jähriger Patient mit nicht bestätigtem Verdacht auf „idiopathische Myelofibrose“. Der Internist. 2011;52(11):1346-1350.Ein 76-jähriger Patient wurde mit Hepatosplenomegalie, Anämie, Thrombopenie, Eosinophilie, Erhöhung der Laktatdehydrogenase und erythroleukämischem Blutbild stationär aufgenommen. Die Knochenmarkhistologie, die Immunhistologie und der molekulargenetische Nachweis der c-kit-Mutation D816 V belegten eine systemische Mastozytose. Eine auswärts vermutete idiopathische Myelofibrose lag nicht vor. Nach Gabe von Prednison erholte sich das Blutbild, der Allgemeinzustand des Patienten besserte sich rasch
Curative treatment in a patient with gastric cancer stage IV: a case report
No full textDiel A, Rodermann E, Kienzle H-F, Meuthen D, Meuthen I. Curative treatment in a patient with gastric cancer stage IV: a case report. F1000Research. 2012;1: 34.A 39-year old patient with gastric adenocarcinoma stage IV failed to respond to preoperative chemotherapies containing 5-FU and cisplatin as well as 5-FU and irinotecan. After third-line chemotherapy with two cycles of docetaxel and cisplatin we confirmed a clinical partial response. A complete histologically confirmed remission was detected after complete resection of the tumor. Following two postoperative cycles of docetaxel and cisplatin, the tumor is still in complete remission after more than eight years
Beyond Words
No full textMeuthen D. Why I foster multiple lines of communication with students in my lab. Science. 2024;384(6691):134.When I started my faculty position, I was excited to be leading my own lab—and nervous. I’m legally deaf and rely on lip-reading for verbal communication. I had managed fine as a graduate student and postdoc, though not without misunderstandings and challenges. But leading a team was different. I worried about whether I would be able to communicate effectively with my lab members, and also whether they would respect me. My pronunciation is sometimes off because of my disability, which leads some people to judge my intelligence as lacking. I set out unsure how to navigate these uncertain waters. But after almost 2 years in the position, I’ve come up with a set of solutions for how best to communicate with my trainees. Many would be useful for any lab head, disabled or not
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Anticipatory plastic response of the cellular immune system in the face of future injury: chronic high perceived predation risk induces lymphocytosis in a cichlid fish
No full textMeuthen D, Meuthen I, Bakker TCM, Thunken T. Anticipatory plastic response of the cellular immune system in the face of future injury: chronic high perceived predation risk induces lymphocytosis in a cichlid fish. Oecologia. 2020;194(4):597–607.Vertebrate cellular immunity displays substantial variation among taxa and environments. Hematological parameters such as white blood-cell counts have emerged as a valuable tool to understand this variation by assessing the immunological status of individuals. These tools have long revealed that vertebrate cellular immune systems are highly plastic and respond to injury and infection. However, cellular immune systems may also be able to anticipate a high risk of injury from environmental cues (e.g., predation-related cues) and respond plastically ahead of time. We studied white blood-cell (leukocyte) profiles in African cichlids Pelvicachromis taeniatus that were raised for 4years under different levels of perceived predation risk. In a split-clutch design, we raised fish from hatching onwards under chronic exposure to either conspecific alarm cues (communicating high predation risk) or a distilled water control treatment. Differential blood analysis revealed that alarm cue-exposed fish had twice as many lymphocytes in peripheral blood as did controls, a condition called lymphocytosis. The presence of a higher number of lymphocytes makes the cellular immune response more potent, which accelerates the removal of invading foreign antigens from the bloodstream, and, therefore, may be putatively beneficial in the face of injury. This observed lymphocytosis after long-term exposure to conspecific alarm cues constitutes first evidence for an anticipatory and adaptive plastic response of the cellular immune system to future immunological challenges
Protecting Animals 36: Author Witi Ihimaera
No full textIn this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
'How warped the mirrors': postmodernism and historiography
No full textPostmodernism, though it may be described in many ways, may be thought essentially to be captured by Lyotard's phrase, 'incredulity towards metanarratives'. The first chapter of my thesis attempts to define both 'postmodernism' and 'historiography', and then surveys historiographical discourse today. Because it is often ancient history that most frequently may be open to radically differing interpretations, I take in chapter two a 'generative' example, namely the speech compositions of Thucydides. This example I consider as 'generative' in the sense that it opens up questions, not only about the History of Thucydides itself and about how Thucydides is conceived in the ancient historiographical tradition, but also about what it means for an historian to disclose the 'truth' of an historical situation. My third chapter takes up the suggestion by Keith Jenkins that postmodern philosophy, particularly the conception of 'truth' and 'knowledge' proffered by Rorty, is a good way for history to acclimatise itself in the postmodern era. I survey Jenkins' proposals, and then discuss a work Jenkins largely ignores, i.e. Rorty's Philosophy and the Mirror of Nature. I demonstrate not just the familiar point that Rorty attempts to overturn 'foundationalist epistemology', and proposes 'new vocabularies' that involve 'hermeneutics' which set up I discourse as 'conversation'. This overturning involves for Rorty an assertion of 'unarbitrability', i.e. that it is impossible to argue that one view is better or more true than another. Thus Jenkins wishes to enter a world of a plurality of interpretations. In chapter four, however, I draw upon the work of Charles Taylor who argues for the necessity of 'arbitrage' in human discourse, whilst still wishing to overturn epistemological foundationalism. I therefore wish to advocate in my fifth chapter a 'third way', drawing on Taylor's theory of interpretation that requires neither a correspondence theory of truth, nor unarbitrability. Throughout the chapter I demonstrate how my conclusions regarding Thucydidean speeches and my discussion of postmodern philosophy may serve as a way of thinking about the task of historians, and hot just ancient historians. I conclude with some theological reflections on the arguments offered
Feeding biology and energetics of King Aptenodytes patagonicus and Gentoo Pygoscelis papua Penguins at sub-Antarctic Marion Island
No full textIncludes bibliographies.Adaptations of penguins for pursuit diving have resulted in reduced foraging ranges, compared to volant seabirds. However, their classification as inshore, offshore or pelagic foragers, based on rates of food provisioning to chicks, still has merit as a framework around which aspects of their feeding biology and allocation of energy within individual energy budgets may be discussed. The average rates at which seabird species supply food to chicks may influence many aspects of their biology. I defined some of the foraging parameters of the pelagic feeding King Penguin Aptenodytes patagonicus and the inshore feeding Gentoo Penguin Pygoscelis papua at sub-Antarctic Marion Island
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