344 research outputs found
Enzyme-Linked Immunosorbent Assay
No full textauthor: Carola BrioschiDiplomarbeit Universität Innsbruck 202
Enzyme-Linked Immunosorbent Assay
No full textauthor: Carola BrioschiDiplomarbeit Universität Innsbruck 202
Blankness: The Architectural Void of North Sea Energy Logistics
No full textEnergy logistics have contributed to the gradual transformation of the North Sea into an industrial void. Referring to the concept of blankness articulated by Roberto Mangabiera Unger and Jeffrey Kipnis, Nancy Couling and Carola Hein call for imaginative architectural interventions that respond to the potential of logistic spaces lodged within the volume of the sea.History, Form & Aesthetic
Effect of Baseline Central Retinal Thickness (CRT) and Best Corrected Visual Acuity (BCVA) on Treatment Outcomes With Intravitreal Aflibercept Injection (IAI) or Macular Laser Photocoagulation in Diabetic Macular Edema (DME)
No full textImpact of baseline Diabetic Retinopathy Severity Scale scores on visual outcomes in the VIVID-DME and VISTA-DME studies
No full textBACKGROUND/AIMS:
To evaluate intravitreal aflibercept versus laser in subgroups of patients with baseline Diabetic Retinopathy Severity Scale (DRSS) scores ≤43, 47, and ≥53 in VIVID-DME and VISTA-DME.
METHODS:
Patients with diabetic macular oedema were randomised to receive intravitreal aflibercept 2 mg every 4 weeks (2q4), intravitreal aflibercept 2 mg every 8 weeks after five initial monthly doses (2q8), or macular laser photocoagulation at baseline with sham injections at every visit. These post hoc analyses evaluate outcomes based on baseline DRSS scores in patients in the integrated dataset. The 2q4 and 2q8 treatment groups were also pooled.
RESULTS:
748 patients had a baseline DRSS score based on fundus photographs (≤43, n=301; 47, n=153; ≥53, n=294). At week 100, the least squares mean difference between treatment groups (effect of intravitreal aflibercept above that of laser, adjusting for baseline best-corrected visual acuity) was 8.9 (95% CI 5.99 to 11.81), 9.7 (95% CI 5.54 to 13.91), and 11.0 (95% CI 7.96 to 14.1) letters in those with baseline DRSS scores ≤43, 47, and ≥53, respectively. The proportions of patients with ≥2 step DRSS score improvement were greater in the intravitreal aflibercept group versus laser, respectively, for those with baseline DRSS scores of ≤43 (13% vs 5.9%), 47 (25.8% vs 4.5%), and ≥53 (64.5% vs 28.4%).
CONCLUSIONS:
Regardless of baseline DRSS score, functional outcomes were superior in intravitreal aflibercept-treated patients, demonstrating consistent treatment benefit across various baseline levels of retinopathy
Effect of Baseline Central Retinal Thickness (CRT) and Best Corrected Visual Acuity (BCVA) on Treatment Outcomes With Intravitreal Aflibercept Injection (IAI) or Macular Laser Photocoagulation in Diabetic Macular Edema (DME)
No full textThe global petroleumscape of the Rotterdam/The Hague area: As a model for further research
No full textFlows of petroleum have shaped the built environment of industrial, retail, administrative, and ancillary spaces, of infrastructures and buildings, as well as their representation. Carola Hein analyses the spatial impact of petroleum on the sea-land continuum through the lens of the port city region of Rotterdam/The Hague.History, Form & Aesthetic
Cromatismo, ritmo, memoria: sulla narrativa di Sergio Atzeni
No full textSergio Atzeni’s works are many and really heterogeneous, both in style and contents. But if we dig up deeply into his texts, we discover that the currents followed by the author are always the same, and that texts that are apparently different have actually significant common aspects.Le opere di Sergio Atzeni sono numerose e molto eterogenee, sia nello stile che nei contenuti. Ma se andiamo a scavare nel profondo, ci rendiamo conto che i filoni seguiti dall’autore sono sempre gli stessi, e che esiti testuali apparentemente distinti hanno in realtà importanti aspetti in comune
Space, Time, and Oil: The Global Petroleumscape
No full textIn addition to explaining the context in which this book emerged, Carola Hein introduces the concept of the petroleumscape, a layered physical and social landscape that reinforces itself over time through human action. The petroleumscape includes different types of interconnected spaces—industrial, administrative, retail, and infrastructural—that are usually considered separately. Hein makes clear why this volume’s case studies pay careful attention to what has been highlighted, downplayed, and hidden as corporate, state, and other relevant actors have attempted to shape perceptions of petroleum and the landscape of which it is a part. Hein also outlines five key stages in the petroleumscape’s development, beginning with the innovations in obtaining petroleum that took place in Pennsylvania in 1859, when petroleum served primarily as a source of lighting fluid, and ending with recent attempts to overcome petroleum dependence.History, Form & Aesthetic
Impact of Baseline Central Retinal Thickness on Outcomes in the VIVID-DME and VISTA-DME Studies
No full textPurpose. To report the impact of baseline central retinal thickness (CRT) on outcomes in patients with diabetic macular edema (DME) in VIVID-DME and VISTA-DME. Methods. Post hoc analyses of two randomized controlled trials in which 862 DME patients were randomized 1 : 1 : 1 to treatment with intravitreal aflibercept 2.0 mg every 4 weeks (2q4), intravitreal aflibercept 2.0 mg every 8 weeks after five initial monthly doses (2q8), or macular laser photocoagulation at baseline and as needed. We compared visual and anatomical outcomes in subgroups of patients with baseline CRT < 400 μm and ≥400 μm. Results. At weeks 52 and 100, outcomes with intravitreal aflibercept 2q4 and 2q8 were superior to those in laser control-treated patients regardless of baseline CRT. When looked at in a binary fashion, the treatment effect of intravitreal aflibercept versus laser was not significantly better in the ≥400 μm than the <400 μm group; when looked at as a continuous variable, baseline CRT seemed to have an impact on the treatment effect of intravitreal aflibercept versus laser. Conclusions. Post hoc analyses of VIVID-DME and VISTA-DME demonstrated the benefits of intravitreal aflibercept treatment in DME patients with baseline CRT < 400 μm and ≥400 μm. This trial is registered with NCT01331681 and NCT01363440
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