218 research outputs found
Effects of Withaferin A on Mouse Models of Alexander Disease
No full textAlexander disease is a rare neurodegenerative disorder which is caused by the accumulation of glial fibrillary acidic protein (GF AP) resulting in aggregates termed Rosenthal Fibers (RFs) in the central nervous system. TAR DNA-binding protein 43(TDP-43) is a DNA/RNA binding protein that is involved in the pathology of disorders
such as amyotrophic lateral sclerosis (ALS) as well as Alexander disease. Withaferin A(WA) is a plant derivative and known inhibitor ofNF-Kl3, and activated NF-KB targets the GF AP promoter. We proposed that treatment of the mice with WA should downregulate the GFAP promoter. We treated 10 week old Alexander disease mutation GFAP
knock-in mice with WA twice a week for 4 weeks. After treatment we analyzed the amount of GF AP protein concentration with an ELISA. Results showed an initial significant decrease in GF AP, but after repeating the experiment and analyzing specific brain regions, treatment was determined to be slightly toxic
Speak No Evil?
No full textResponds to comments by T. P. O\u27Brien and P. Cox (1997), and M. L. Perla (1997) regarding the author\u27s (G. W. Albee, see record 84-09296) article on prevention science. Albee discusses the problems in Perla\u27s call for more public visibility for prevention programs using social marketing principles, and disagrees with O\u27Brien and Cox\u27s argument for the separation of science and politics
Kazuo Ishiguro speaks in Dominican author series
No full textKazuo Ishiguro, author of The Remains of the Day, spoke at Dominican on April 1, as part of Dominican’s Spring Author Series, presented in partnership with Book Passage
Archetypal and New Families With Alexander Disease and Novel Mutations in <emph type="ital">GFAP</emph>
No full text
Dominican welcomes bestselling author Erik Larson
No full textNew York Times bestselling author and former features writer for the Wall Street Journal and Time Magazine, Erik Larson spoke at Dominican University of California on April 14, at the Institute for Leadership Studies’ (ILS) Spring Author Series, presented in partnership with Book Passage
\'Three tall women\' by Eduard Albee: autobiography or criticism concerning the American society?
No full textNo prefácio da peça Three Tall Women, o dramaturgo norte-americano Edward Albee declara ter-se baseado em sua mãe adotiva para a composição de sua personagem. Por esse motivo, a crítica teatral norte-americana passou a considerar a peça simplesmente como uma autobiografia de seu autor. É fato que Edward Albee se utilizou de elementos de sua própria vida na obra, mas a peça não se restringe a isso: a autobiografia serviu de ferramenta para a realização de uma crítica contundente aos valores cultivados pela classe média alta norte-americana. Grande parte da crítica norte-americana, ao se referir à peça Three Tall Women, ressalta seu aspecto autobiográfico, mas não toca, de forma alguma, no aspecto de crítica à ideologia norte-americana presente na obra. Dessa forma, a presente dissertação propõe-se a identificar e analisar os elementos de crítica à sociedade norte-americana encontrados na peça Three Tall Women, por meio da análise dos diálogos de seus personagens. Finalmente, este trabalho também analisará a convergência entre a forma e o conteúdo nessa obra, ou seja, a forma mais adequada, escolhida pelo autor, para a exposição de determinado conteúdo.In the play Three Tall Women, the American playwright Edward Albee states that one of his characters is based on his adoptive mother. For this reason, American critics consider the play essentially an autobiography of its author. It is true that Edward Albee has used some elements of his life in his play, but Three Tall Women is not limited to that: Edward Albee\'s autobiography is like a tool for the crushing criticism concerning some values supported by the American high-middle class. A great part of the American critics emphasizes the autobiography element concerning the play Three Tall Women, but definitely they do not mention the aspect of criticism about the American ideology in the play. In this way, this paper aims to identify and to analyze the elements of criticism concerning the American society found in the play Three Tall Women through the characters dialogues. Finally, this paper also aims to analyze the convergence between form and theme; the most adequate form, chosen by the author, for the presentation of such theme
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