1,721,019 research outputs found
DIFFERENCES IN BRAIN STRUCTURE AND FUNCTION IN PRIMARY HEADACHE DISORDERS: A MULTIMODAL MRI STUDY
No full textApplication of advanced magnetic resonance imaging techniques to better understand the pathophysiology of migraine and other primary headache disorders, such as cluster headache.Application of advanced magnetic resonance imaging techniques to better understand the pathophysiology of migraine and other primary headache disorders, such as cluster headache
Turbulence modulation in particle laden pipe flow: exact regularized point particle method
No full textMany technological applications are characterized by turbulent bounded flows with dispersed particles. For high mass load (particle/fluid mass ratio) a significant inter-phase momentum exchange occurs (two-way coupling regime), inducing a significant alteration of the turbulent field which, in turn, modifies the dynamics of the suspended phase. Aim of the present study is exploring the potentially of recently developed momentum coupling method, dubbed the Exact Regularized Point Particle (ERPP) method, in reproducing via Direct Numerical Simulation (DNS) the detailed dynamics of a particles laden turbulent pipe flow. The comparison with available experimental and numerical data confirms the ability of the new approach in reproducing the relevant dynamics also in parameter ranges which are unaccessible to standard techniques
Comparison of efficacy and safety of erenumab between over and under 65-year-old refractory migraine patients: a pivotal study
No full textPrevious studies reported a positive effect of anti-CGRP monoclonal antibodies (mAbs) in migraine prevention, either in over (O65) and under (U65) 65-year-aged patients. The aim of our study was to evaluate and compare real-life efficacy and safety of mAbs between young and elder migraine patients. Fifteen O65 and fifteen U65 patients, treated with monthly mAbs for 6 months, were enrolled and matched for sex, monthly headache days (MHD), and monthly migraine days (MMD) at baseline. Between-group differences in MHD and MMD, number of pills and days of acute medication intake, HIT-6, MIDAS, Numeric Rating Scale (NRS), and Allodynia Symptom Checklist (ASC-12) were assessed after 3 (M3) and 6 (M6) months of treatment. Adverse events (AEs) were also investigated. In each group, thirteen patients (87%) were women and nine (60%) had chronic migraine. Baseline mean MHD and MMD of both groups were 20 (SD 9.6). Mean age was 70 (65-76) and 45 (19-55) in the O65 and U65 group, respectively. Before starting mAbs, patients have tried an average of 4 preventives in both groups. After 3 and 6 months of treatment, both groups had a reduction of all clinical features under examination, without statistically significant differences between groups. A similar proportion of patients in each group complained of AEs (M3 and M6, p = 1.0). Our real-life data showed that treatment with mAbs is as effective and safe in O65 as U65 migraine patients. Further studies are needed to confirm these findings
“Dinanzi al morire e attaccamento: stili di attaccamento, qualità del supporto emotivo e alleanza col medico nella fase terminale della malattia oncologica
No full textpeer reviewedWe tested the hypothesis that security of attachment may act as protective factor for psychological distress in hospice patients with cancer in the terminal phase. We hypothesized that security of attachments may influence positively both the emotional support provided by the caregiver and the quality of the working alliance with physicians. 37 hospice patients with advanced cancer disease, their caregivers and 4 physicians participated to the study. The results supported the hypothesis. Patients with secure attachment perceived more emotional support from the caregiver, they were also more able to reciprocate and provide more emotional support to the caregiver; secure individuals perceived better working alliance with physician
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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