3,613 research outputs found
Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure
No full textBACKGROUND: Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH, such as Roundup, pose a particular health risk to liver and kidneys although low environmentally relevant doses have not been examined. To address this issue, a 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via drinking water (giving a daily intake of 4 ng/kg bw/day of glyphosate) was conducted. A marked increased incidence of anatomorphological and blood/urine biochemical changes was indicative of liver and kidney structure and functional pathology. In order to confirm these findings we have conducted a transcriptome microarray analysis of the liver and kidneys from these same animals.
RESULTS: The expression of 4224 and 4447 transcript clusters (a group of probes corresponding to a known or putative gene) were found to be altered respectively in liver and kidney (p < 0.01, q < 0.08). Changes in gene expression varied from -3.5 to 3.7 fold in liver and from -4.3 to 5.3 in kidneys. Among the 1319 transcript clusters whose expression was altered in both tissues, ontological enrichment in 3 functional categories among 868 genes were found. First, genes involved in mRNA splicing and small nucleolar RNA were mostly upregulated, suggesting disruption of normal spliceosome activity. Electron microscopic analysis of hepatocytes confirmed nucleolar structural disruption. Second, genes controlling chromatin structure (especially histone-lysine N-methyltransferases) were mostly upregulated. Third, genes related to respiratory chain complex I and the tricarboxylic acid cycle were mostly downregulated. Pathway analysis suggests a modulation of the mTOR and phosphatidylinositol signalling pathways. Gene disturbances associated with the chronic administration of ultra-low dose Roundup reflect a liver and kidney lipotoxic condition and increased cellular growth that may be linked with regeneration in response to toxic effects causing damage to tissues. Observed alterations in gene expression were consistent with fibrosis, necrosis, phospholipidosis, mitochondrial membrane dysfunction and ischemia, which correlate with and thus confirm observations of pathology made at an anatomical, histological and biochemical level.
CONCLUSION: Our results suggest that chronic exposure to a GBH in an established laboratory animal toxicity model system at an ultra-low, environmental dose can result in liver and kidney damage with potential significant health implications for animal and human populations
Happy Hour with Robin Sacks
No full textRobin Sacks is the author of Get Off My Bus!: How to Get Clarity, Get in the Driver\u27s Seat, and Get Moving in Your Life! Introduction by Kristen Kuhlman, LSW, LHNA, MBA/HCM DHA Candidate
Toxicity of Pesticides on Health and Environment
No full textPublic policy is regularly shaken by health crises or unexpected discoveries; future directions in toxicology assessment are therefore urgently needed. Convergent evidences suggest endocrine or nervous disrupting effects of pesticides, as well as effects on wildlife and the environment. These effects are amplified by the use of surfactants and/or combinations of different active principles. The usual concepts of regulatory toxicology are challenged by endocrine, nervous or immune disruption, or epigenetic effects. Indeed, most pollutants alter cell-cell communication systems to promote chronic diseases. They may accumulate in the food chain. Mixtures effects with other pollutants may change their bioavailability and their toxicity. The lack of scientific knowledge in these matters has large costs for public health. This Research Topic focuses on the toxic effects of pesticides associated with large scale cultivation of genetically modified (GM) plants
Public management : Reinventing Government: a symposium. by Robin Butler
No full texttag=1 data=Public management : Reinventing Government: a symposium. by Robin Butler
tag=2 data=Butler, Robin
tag=3 data=Public Administration,
tag=4 data=72
tag=5 data=2
tag=6 data=Summer 1994
tag=7 data=263-270.
tag=8 data=MANAGEMENT%PUBLIC SERVICE
tag=10 data=The author indicates how the major themes of the book [Reinventing Government] can be seen to correspond with many of the recent management initiatives in UK government.
tag=11 data=1994/6/8
tag=12 data=94/0490
tag=13 data=CABThe author indicates how the major themes of the book [Reinventing Government] can be seen to correspond with many of the recent management initiatives in UK government
Robin Becker, 16th Annual ODU Literary Festival
No full textRobin Becker is the author of Giacometti’s Dog, published in 1990 by the University of Pittsburgh Press. Her previous books are Backtalk and Personal Effects, both published by Alice James Books She has received fellowships in poetry from the Massachusetts Artists Foundation and the National Endowment for the Arts. Her poems appear in many journals including Agni, The American Poetry Review, The Kenyon Review, and Ploughshares. She has published book reviews in Belles Lettres, The Boston Globe, The Boston Review, Prairie Schooner and The Women’s Review of Books She teaches in the Program in Writing and Humanistic Studies at Massachusetts Institute of Technology. This year she is Visiting Poet at Pennsylvania State University. Robin Becker serves as Poetry Editor for The Women’s Review of Books and as a member of the board of directors of Associated Writing Programs
Author Robin Silbergleid reads from her memoir "Texas girl," and her soon to be published book of poetry, "The baby book" at the Michigan Writers Series
No full textAuthor Robin Silbergleid reads from her memoir "Texas girl," and her soon to be published book of poetry, "The Baby Book." Introductory remarks are provided by MSU Professor Telaina Eriksen and MSU Librarian Michael Rodriguez. Part of the MSU Libraries' Michigan Writers Series. Held at the MSU Main Library and sponsored by the MSU Department of English and the Center for Gender in Global Context
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