4 research outputs found
Data for: Socioeconomic determinants of nutritional status among 'Baiga' tribal children in Balaghat district of Madhya Pradesh: A qualitative study
No full textProject Summary
The design of the study is qualitative, it includes data from twenty in-depth interviews with the mothers of Severe acute malnutrition (SAM) and Moderate acute malnutrition (MAM) children from seven different villages to explore the social and cultural factors affecting the nutritional status among the children of Baiga tribes. Seven formal interviews with the public servants - one Integrated Child Development Services (ICDS) supervisor, one PDS (Public Distribution System) supplier, five Anganwadi worker (AWW), were conducted to gain insight into stakeholders’ perspectives and challenges faced by them.
Data Overview
Both random and purposive sampling techniques have been used to select the villages and participants. In all, seven villages were selected from those pockets where the Baiga tribal population is high, but sampling of the mothers of SAM and MAM affected children, public servants and other stakeholders viz Local Registered Medical Practioners (RMP ), medical officer and district official were purposive. Detailed demographic and social profiling of the villages was carried out with specific focus on villages under study. Interviews were conducted in Hindi and transcribed and translated to English by the author
A Clinical Study to Evaluate the Efficacy of Khasa Beeja Taila (Seed Oil of Papaver Somniferum Linn.) in Darunaka Vyadhi
No full textDarunaka Vyadhi, described under Kshudra Rogas and Kapalagata Rogas in Ayurvedic texts, is closely related to dandruff - a common scalp disorder. It is characterized by scalp flaking, itching, and dryness without visible inflammation. Classical references suggest the use of Khasa Beeja Taila (seed oil of Papaver somniferum Linn.) for managing Darunaka Vyadhi. Aim: To evaluate the efficacy and safety of Khasa Beeja Taila (seed oil of Papaver somniferum Linn.) as an external application in the management of Darunaka Vyadhi (dandruff). Objectives: Primary Objective: To assess the anti-dandruff efficacy of Khasa Beeja Taila based on reduction in Adherent Scalp Flaking Score (ASFS) and 5D Pruritis Scale. Secondary Objective: To evaluate the safety and tolerability of Khasa Beeja Taila through clinical observations and hematological parameters (CBP, ESR). Methods: An open-label, single-arm pilot clinical study was conducted on 30 subjects diagnosed with Darunaka Vyadhi. The intervention involved external application of Khasa Beeja Taila twice weekly for four weeks. Efficacy was assessed using the Adherent Scalp Flaking Score (ASFS), 5D Pruritis Scale, and grading scales for Kandu, Twak Sphutana, Keshabhoomi Rookshata, and Keshachyuti. Safety assessments included Complete Blood Picture (CBP) and Erythrocyte Sedimentation Rate (ESR) evaluations. Results: Statistically significant improvements were noted across all parameters. ASFS and 5D Pruritis Scale showed highly significant reductions (p<0.0001) from baseline to the 4th week. Symptoms like Kandu, Twak Sphutana, Keshabhoomi Rookshata, and Keshachyuti significantly reduced over the treatment period. No adverse effects or significant changes in CBP and ESR were recorded, confirming the safety of the formulation. Conclusion: Khasa Beeja Taila demonstrated significant clinical efficacy and safety in managing Darunaka Vyadhi. The results indicate its potential as a natural remedy for dandruff and related symptoms, warranting further large-scale studies
A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation
No full textmRNA-circRNA-miRNAs axes have been characterized in breast cancer, but not as risk-assessment axes for tumor initiation in early-onset breast cancer that is increasing drastically worldwide. To address this gap, we performed circular RNA (circRNA) microarrays and microRNA (miRNA) sequencing on acini of HMT-3522 S1 (S1) breast epithelial risk-progression culture model in 3D and chose an early-stage population miRNome for a validation cohort. Nontumorigenic S1 cells form fully polarized epithelium while pretumorigenic counterparts silenced for gap junction Cx43 (Cx43-KO-S1) lose epithelial polarity, multilayer and mimic premalignant in vivo mammary epithelial morphology. Here, 121 circRNAs and 65 miRNAs were significantly dysregulated in response to Cx43 silencing in cultured epithelia and 15 miRNAs from the patient cohort were involved in epithelial polarity disruption. Focusing on the possible sponging activity of the validated circRNAs to their target miRNAs, we found all miRNAs to be highly enriched in cancer-related pathways and cross-compared their dysregulation to actual miRNA datasets from the cultured epithelia and the patient validation cohort. We present the involvement of gap junction in post-transcriptional axes and reveal Cx43/hsa_circ_0077755/miR-182 as a potential biomarker signature axis for heightened-risk of breast cancer initiation, and that its dysregulation patterns might predict prognosis along breast cancer initiation and progression. © 2021, The Author(s)
