10,739 research outputs found
AA amyloidosis: Basic knowledge, unmet needs and future treatments
No full textSystemic AA amyloidosis is a long-term complication of several chronic inflammatory disorders, including rheumatoid arthritis, ankylosing spondylitis, autoinflammatory syndromes, Crohn’s disease, malignancies and conditions predisposing to recurrent infections. Organ damage results from the extracellular deposition of proteolytic fragments of the acute-phase reactant serum amyloid A (SAA) as amyloid fibrils. A sustained high concentration of SAA is the prerequisite for developing AA amyloidosis. However, only a minority of patients with long-standing inflammation actually presents with this complication, pointing to the existence of disease-modifying factors, the best characterised of which being SAA1 genotype. The kidneys, liver and spleen are the main target organs of AA amyloid deposits. In more than 90% of patients proteinuria, nephrotic syndrome and/or renal dysfunction dominate the clinical picture at onset. If not effectively treated, this disease invariably leads to end stage kidney disease and renal replacement therapy, that are still associated with a poor outcome.
Although the incidence of AA in rheumatoid arthritis and other chronic arthritides has continuously decreased over the past ten years, thanks to the increasing availability of more effective anti-inflammatory and immunosuppressive therapies, AA remains a life-threatening disease with several areas of uncertainty and unmet needs, deserving continuous efforts at prevention and effective treatment. The deeper understanding of the molecular mechanisms of amyloid formation and regression is now driving the development of novel treatments targeting different steps in the amyloidogenic cascade. These therapies will hopefully improve the quality of life and outcome of these patients in a near future
L’INTERPRETAZIONE DIALOGICA TRA CINEMA E MEDIA DIGITALI: IL GIFFONI FILM FESTIVAL COME CASO DI STUDIO.
No full textLa ‘svolta digitale’ ha trasformato ogni aspetto della nostra vita, ivi compreso l’ecosistema mediatico, il quale oggi è permeato dai nuovi mezzi di comunicazione informatico-digitali (Bentivegna-Boccia Artieri 2018; Jensen 2021a). Tale ‘svolta’ (si veda Fantinuoli 2018) sta influenzando anche i servizi di interpretazione. A tal proposito, in questa tesi si analizza se e come un nuovo mezzo come lo streaming via YouTube, nonché l’uso dell’interpretazione a distanza introdotto durante la pandemia da Covid-19, abbiano un impatto su prestazioni dialogiche di film festival interpreting (FFI, Merlini 2017), come pure sulla ricezione delle stesse da parte di potenziali utenti. L’analisi verte sui concetti di audience design (Bell 1984, 1991), agentività degli interpreti e loro visibilità su schermo.
A tal fine si adotta una metodologia mista. In primo luogo, si analizza qualitativamente un corpus multimodale di prestazioni interpretative autentiche IT<>EN offerte nelle ultime edizioni del Festival di Giffoni (2017-2020): questo celebre festival internazionale si tiene ogni anno dal 1971 a Giffoni Valle Piana (Salerno) e si rivolge a una platea di ragazzi e ragazze; alcuni dei suoi eventi sono accessibili da parte di un pubblico remoto tramite live streaming e nel 2020 ha utilizzato l’interpretazione a distanza a causa della pandemia. Si analizzano eventi in presenza in streaming, eventi a distanza in streaming ed eventi in presenza privi dello streaming. Oltre al framework teorico di Bell, si utilizzano altresì la nozione di footing (Goffman 1981; Wadensö 1998; Merlini & Favaron 2005), quella di positioning (Davies & Harré 1990; Harré & Van Langenhove 1999; Mason 2005; Merlini 2009), di spatial positioning (si veda Pokorn 2015), nonché di “etica dell’intrattenimento” (Katan & Straniero Sergio 2001). Quanto a quest’ultimo, dato che il FFI è considerato una sottocategoria ancora poco esplorata di media interpreting (Merlini 2017), l’apporto di studi come quelli di Straniero Sergio (es. 2007) è imprescindibile.
La componente quantitativa dello studio include la somministrazione di due questionari tramite cui si indagano le aspettative e l’effettiva ricezione di videoclip autentiche tratte dal corpus; l’analisi è supportata dalla raccolta di dati statistici secondari relativi ai consumi mediatico-digitali. Il secondo questionario (studio ricettivo) verte in particolare sui concetti di audience design e di visibilità su schermo: cinque estratti trascritti analizzano la ricezione di strategie di adeguamento di tecnicismi cinematografici e altre cinque videoclip indagano la ricezione di una crescente visibilità su schermo della gestualità degli interpreti.
L’analisi qualitativa del corpus dimostra che la ‘svolta digitale’ ha un impatto sulla prestazione interpretativa: lo streaming e la remoteness rendono il FFI diverso dal media interpreting televisivo. Ciò è riscontrabile soprattutto in termini di agentività e visibilità su schermo, ma anche relativamente ad alcuni passaggi specifici relativi all’audience design. Gli interpreti dialogici che lavorano al Giffoni rappresentano una figura professionale ibrida, né del tutto affine a quella descritta da Wadensjö (1993/2002) né a quella discussa in Jüngst (2012), ora simile ora lontana dagli esempi analizzati da Straniero Sergio (2007), finanche più conforme a dei simultaneisti piuttosto che a dei consecutivisti.
Se l’audience design e la visibilità su schermo degli interpreti non sono ritenuti importanti in termini di aspettative, di converso nello studio ricettivo si afferma la loro rilevanza. Da una parte, infatti, la maggior parte dei rispondenti valuta positivamente le strategie di audience design utilizzate dagli interpreti. Dall’altra parte considera importante che l’interprete sia visibile su schermo, tanto per porre in evidenza la sua professionalità, quanto per garantire l’intelligibilità dell’interazione.
I dati raccolti e analizzati in questa sede possono altresì essere utili da un punto di vista didattico: a tal fine si presenta brevemente un modello pedagogico (socio-)costruttivista volto a mettere in risalto come i contenuti disponibili in YouTube possano supportare la formazione di interpreti dialogici, sia in un contesto mediatico come quello qui indagato, sia in setting sanitari.The ‘digital turn’ has changed each and every aspect of our lives, including the media ecosystem, which is today dominated by the new digital media (Bentivegna-Boccia Artieri 2018; Jensen 2021a). This ‘turn’ (see Fantinuoli 2018) is having an impact even on interpreting services. In light of this, my doctoral dissertation analyses whether and how a new medium like YouTube web-streaming, as well as the distance interpreting mode introduced because of the Covid-19 pandemic, have an impact on both dialogue film festival interpreting (FFI) practices (Merlini 2017) and on their reception by potential users. The analysis focuses on audience design (Bell 1984, 1991), interpreters’ agency and their visibility on screen.
To this end, a mixed methods design has been used. First of all, as far as the qualitative strand is concerned, I analyse a multimodal corpus of authentic interpreting performances IT<>EN taken from the latest editions of the Giffoni Film Festival (2017-2020); this famous international festival, which has been taking place since 1971 in Giffoni Valle Piana (Salerno, Italy), addresses an audience made up entirely of children and young people. Some of its events are live-streamed and therefore are open to a remote audience; in 2020, because of the Covid-19 pandemic, it used distance interpreting as well. My corpus includes onsite streamed events, distance streamed events and onsite non-streamed events. In addition to Bell’s theoretical framework, I draw upon the following concepts: footing (Goffman 1981; Wadensö 1998; Merlini & Favaron 2005), positioning (Davies & Harré 1990; Harré & Van Langenhove 1999; Mason 2005; Merlini 2009), spatial positioning (see Pokorn 2015), as well as the “ethics of entertainment” (Katan & Straniero Sergio 2001). As for the latter, since FFI is an under-investigated subcategory of media interpreting (Merlini 2017), the contribution of such studies as the ones by Straniero Sergio (e.g.: 2007) has been essential.
The quantitative strand is composed of two questionnaires, which analyse both expectations and the actual reception of authentic videoclips taken from my corpus. The analysis is supported by secondary statistical data in terms of media-digital consumption. The second questionnaire (reception study) deals specifically with audience design and visibility on screen: five transcript excerpts focus on how interpreters adjust cinema-related terms to their audiences; and five videoclips show an increasing visibility of interpreters’ gestures on screen.
The qualitative corpus analysis shows that the ‘digital turn’ has an impact on these interpreting performances: both the web-streaming and the remoteness features make FFI different from televised interpreting. This is particularly true in terms of agency and visibility on screen, but also in terms of some audience design-focused analyses. The Giffoni’s dialogue interpreters represent a hybrid category, in that they are neither totally similar to the ones described by Wadensjö (1993/2002) nor to those depicted by Jüngst (2012); sometimes they recall the interpreters’ profiles described by Straniero Sergio (2007), and sometimes they may resemble simultaneous interpreters rather than consecutive or dialogue ones.
The analysis of potential users’ expectations shows that both audience design and visibility on screen are not considered to be essential factors, whereas the reception study highlights their importance. On the one hand, most of the respondents positively rate the strategies interpreters used to adjust their terms to their audiences; on the other hand, according to them, interpreters are to be visible on screen, both in acknowledgment of their professional status and to guarantee the intelligibility of interactions.
The data I collected and analysed in this doctoral dissertation may be used for didactic purposes as well. To this end, a (socio-)constructivist pedagogical model is briefly presented: this shows how the multimodal contents available on YouTube can be used to educate dialogue interpreters, both in a media-related context like the one I analysed here, and in healthcare settings
Correspondence: Laura Kephart and Arthur Stupka
No full textThis 1936 correspondence, between Laura Kephart (Mrs. Horace Kephart) and Arthur Stupka, concerns a possible Kephart Memorial. Horace Kephart (1862-1931) was a noted naturalist, woodsman, journalist, and author and promoter of the Great Smoky Mountains National Park. Arthur Stupka (1905-1999) was the first park naturalist to work at the Great Smoky Mountains National Park
Mindscapes: Laura Riding's poetry and poetics /
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão.Esta tese propõe uma leitura revisionista da poesia contemporânea através do exame do caso de um dos mais esquecidos escritores norte-americanos do século XX: Laura (Riding) Jackson (1901-1991). O objetivo é demonstrar que Riding não apenas possuía uma poética definida e singular, mas que ela permanece uma das instâncias mais extremas e paradoxais do modernismo anglo-americano, a ponto de Riding abandonar a escrita da poesia em 1938. Recorrendo a conceitos de "formação do cânone" bem como às noções de "discurso" e "função do autor", em Foucault, investigo a construção do cânone da poesia moderna anglo-americana, recuperando o contexto e as circunstâncias da ocultação de Riding. Enquanto cubro os "discursos" poéticos em circulação na primeira metade do século XX-o "imagismo" de Pound, a "dissociação da sensibilidade", "impersonalidade" e "tradição" de Eliot, a "unidade orgância" e "ambigüidade" da Nova Crítica-ofereço um panorama crítico de modernismos alternativos sendo articulados à época. Minha intenção é demonstrar que os poemas de Riding são expressões vigorosas de um escritor para quem "a mente pensando se torna a força ativa do poema", para usar a apta formulação de Charles Bernstein. Entre minhas descobertas sobre as várias e complexas razões que levaram à não-canonização de Riding estão a hegemonia da Nova Crítica, o exílio voluntário de Riding da cena literária (onde são feitas ou desfeitas as reputações), sua recusa em ser antologiada, bem como em ser explicada em termos críticos que não os dela. Todos esses fatores, mais a "dificuldade" de sua poesia, contribuíram para fazer de Riding "a maior poeta esquecida da poesia norte-americana", como escreveu Kenneth Rexroth. Ajudado pelos insights de dois importantes críticos de poesia norte-americana, Charles Bernstein e Marjorie Perloff, defendo que a "poesia da mente" de Riding-onde o que está em jogo é que o que pensamos ser a nossa realidade-representa uma mudança radical no paradigma da poética modernista: de uma poesia centrada na imagem para uma poesia centrada na linguagem. Focalizando a experiência consciente e o tempo duracional do pensamento presente em seus poemas, concluo que as "pensagens" de Riding têm o objetivo preciso de constatar um fato universal: enquanto seres humanos e pensantes, estamos numa condição permanente chamada linguagem
Letter, Julia Gardiner Tyler to Mrs. Laura Holloway, author of First Ladies, dated September 20, 1869
No full textALS of Julia Gardiner Tyler to Mrs. Laura Holloway, author of First Ladies, dated September 20, 1869, about interviewing other first ladies. ALS.Found in:Mss. 65 T97 Additions, Series 1: Mss. Acc. 1993.19 Addition, 186
Heritage tourism: a case study of the Laura Ingalls Wilder Heritage Site at Pepin, Wisconsin
No full textPlan BMany things must be taken into consideration when developing a heritage tourism site. It can be a wonderful opportunity for the community involved to benefit economically and historically. Heritage tourism can keep alive the heritage and traditions of the communities past. When it is discovered that a heritage site exists, the first step is to consult with the community. A site will not succeed without the acceptance and assistance from the community involved. Once the interest is known, the development process can proceed. After determining that there is a heritage tourism site possibility in their area, a commumity must do research to determine the feasibility of the site, what will make it a success, and how to obtain that success. This study will examine a community with a heritage tourism site that has been successful in developing and maintaining it's site. By conducting this study, other communities seeking information for developing their site will have an example and tool to work with. The site chosen for this study is the Laura Ingalls Wilder site in Pepin, Wisconsin. The town is rich with it's heritage associated with Laura Ingalls Wilder. The development and success for this town will be documented through this study. Laura Ingails Wilder is a perfect choice for examining heritage tourism. The author of many American Pioneer books, she has become famous all over the world. In turn all places that she or her family members lived are or are becoming heritage tourism sites. There are older ones that have been in progress for some years, such as the one in Pepin, and there are ones that are being discovered through the popularity of new books written about Laura's family. These communities would benefi greatly from the information this study will produce. Without the bene-fit of this knowledge communities who are unaccustomed to tourism or the way the other Laura Ingalls Wilder sites operate, may make terrible errors in development, tarnishing the site. This may also reflect badly on the other Laura Ingalls Wilder sites. It is important for new Wilder sites to examine all information and know exactly what they are doing when developing the site. If all the Laura Ingalls Wilder sites can benefit from each other's knowledge and experience it will greatly increase the market for all sites. The more detailed and expansive the sites are about their knowledge and sites to see, the more people are going to want to travel to as many sites as possible, learning all they can about the life of Laura Ingalls Wilder and her family. These sites not only attract Laura Ingalls Wilder fans but all people that are interested in the American Pioneer period of the United States history. This study will provide the knowledge for communities who are developing heritage tourism sites, especially those focusing on Laura Ingalls Wilder. This is a very important study for tourism and especially heritage tourism. When a heritage site is discovered communities run into the barrier of not having the experience and knowledge to develop the site properly. This study will analyze tourism in Pepin, Wisconsin to determine it's successfulness due to the fact that it is a Laura Ingalls Wilder heritage tourism site, and Wfit was developed in a way to provide tourists with a view of Laura Ingalls Wilder's past and the past of many Pioneer Americans. By studying this subject it will allow for many people to benefit. Tourist who are seeking the pleasure of the knowledge of the past, and communities who want to preserve their past and profit from tourism
Core Journal Lists: Classic Tool, New Relevance
No full textReviews the historical context of core journal lists, current uses in collection assessment, and existing methodologies for creating lists. Outlines two next generation core list projects developing new methodologies and integrating novel information/data sources to improve precision: a national-level core psychology list and the other a local institutional core list for the interdisciplinary field of urban studies and planning. The paper is based on the authors’ panel presentation at the 2009 ACRL National Conference (Seattle, Washington) titled “Core Journal Lists Re-viewed and Re-imagined.”This is an electronic version of an article published in Robin A. Paynter, Rose M. Jackson & Laura Bowering Mullen (2010): Core Journal Lists: Classic Tool, New Relevance, Behavioral & Social Sciences Librarian, 29:1, 15-31. Behavioral & Social Sciences Librarian is available online at: http://www.tandfonline.com, http://dx.doi.org/10.1080/01639260903571096Peer reviewe
IATUL 32nd Conference 2011, “Libraries for an Open Environment: Strategies, Technologies and Partnerships,” Warsaw University of Technology, Warsaw, Poland, 29 May-2 June 2011
No full textThis report provides details recorded from the author's attendance at the IATUL 2011 conference in Warsaw, Poland, May 29-June 2, 2011.This is a post-print version of an article that published in Library Hi Tech News. The published version is available at http://www.emeraldinsight.com/journals.htm?issn=0741-9058&volume=28&issue=8&articleid=1958452&show=abstrac
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