1,721,021 research outputs found
Portable system for practical permittivity measurements improved by homomorphic deconvolution
No full textThis paper presents a versatile low-cost procedure for complex permittivity measurements of liquids from 400 MHz to 5 GHz. Our procedure uses handheld instrumentation and custom software for data acquisition and postprocessing. The purpose is to replace the benchtop vector network analyzer (VNA) generally used in such applications with a portable and cheaper handheld spectrum analyzer used in the VNA mode. Postprocessing software based on homomorphic deconvolution is used to remove possible inaccuracies in the permittivity spectra coming from the reduced performance of the handheld VNA with respect to benchtop models. Our measurements are evaluated by comparison with those of the National Physical Laboratory (NPL). The results of the real and imaginary parts of the permittivity spectra of two well characterized organic compounds, ethanediol and 2-propanol, are in very good agreement with the NPL reference standards, showing a relative root-mean-square error (RRMSE) always less than 5%. Low values of the RRMSE, together with an expanded uncertainty less than 3%, ensure that our permittivity measurements are repeatable and accurate. Thanks to its versatility, portability, and at least half of the cost of commercial models, our system is suitable for on-site measurements in different applications, including food quality monitoring and control of medical treatments and biological procedure
Machine-Learning for Optimization of Electrodes and Waveforms for Electroporation
No full textThe adoption of high-frequency irreversible electroporation in a variety of medical treatments is more and more frequent. Unfortunately, a large number of parameters can influence the efficiency and effectiveness of the electroporation procedures: suitable choices of electrodes and of the stimulating signals being some important examples. In this paper, we demonstrate that machine-learning strategies based on Neural Networks are an appropriate approach to optimize the choice of the electrode characteristics, and we discuss the extension of alternative Machine Learning approaches to the optimization of the stimulating waveforms
Comparison of Transcranial Magnetic Stimulation Dosimetry between Structured and Unstructured Grids Using Different Solvers
Full text linkIn recent years, the interest in transcranial magnetic stimulation (TMS) has surged, necessitating deeper understanding, development, and use of low-frequency (LF) numerical dosimetry for TMS studies. While various ad hoc dosimetric models exist, commercial software tools like SimNIBS v4.0 and Sim4Life v7.2.4 are preferred for their user-friendliness and versatility. SimNIBS utilizes unstructured tetrahedral mesh models, while Sim4Life employs voxel-based models on a structured grid, both evaluating induced electric fields using the finite element method (FEM) with different numerical solvers. Past studies primarily focused on uniform exposures and voxelized models, lacking realism. Our study compares these LF solvers across simplified and realistic anatomical models to assess their accuracy in evaluating induced electric fields. We examined three scenarios: a single-shell sphere, a sphere with an orthogonal slab, and a MRI-derived head model. The comparison revealed small discrepancies in induced electric fields, mainly in regions of low field intensity. Overall, the differences were contained (below 2% for spherical models and below 12% for the head model), showcasing the potential of computational tools in advancing exposure assessment required for TMS protocols in different bio-medical applications
A microdosimetric study of electropulsation on multiple realistically shaped cells. Effect of Neighbours
No full textOver the past decades, the effects of ultrashort-pulsed electric fields have been used to investigate their action in many medical applications (e.g. cancer, gene electrotransfer, drug delivery, electrofusion). Promising aspects of these pulses has led to several in vitro and in vivo experiments to clarify their action. Since the basic mechanisms of these pulses have not yet been fully clarified, scientific interest has focused on the development of numerical models at different levels of complexity: atomic (molecular dynamic simulations), microscopic (microdosimetry) and macroscopic (dosimetry). The aim of this work is to demonstrate that, in order to predict results at the cellular level, an accurate microdosimetry model is needed using a realistic cell shape, and with their position and packaging (cell density) characterised inside the medium
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Intraneural Device for Electrostimulation of Vagus Nerve in Rats: A Feasibility Study for Modulating Glucose Tolerance
No full textObjectives: This study introduces EMPATIC (Electro-Modulation of PAncreaTic Islet Cells), a miniaturized intraneural device designed for transversal insertion into small nerves with a mean diameter of 400 μm. EMPATIC aims to modulate glucose tolerance through intraneural vagus nerve stimulation (VNS) in rats. Materials and Methods: EMPATIC design was optimized to fit into the cervical vagus nerve of rats and was developd through thin film microtechnologies. We evaluated the efficacy of the stimulation protocol (200 μA for 10 μs at 1 Hz) on glucose tolerance after intraperitoneal injection of glucose in three rat groups: control (no implant), sham (EMPATIC implant, no stimulation), and VNS (EMPATIC implant with stimulation). Results: EMPATIC treatment in the VNS group significantly affected glucose tolerance tests compared with control and sham groups. The glucose tolerance test's area under the curve was 17,652 ± 913 mg∗min/dL in the control group, 16,929 ± 765 mg∗min/dL in the sham group, and reduced to 12,749 ± 1,075 mg∗min/dL in the stimulated group with statistical significance (p < 0.05 stimulated vs sham group, p < 0.05 stimulated vs control group). Blood glucose and insulin levels were measured, also under fasting conditions, for control and VNS groups, producing no statistically significant difference. Conclusions: EMPATIC treatment is effective in hyperglycemic conditions after glucose intake. No significant effects were observed when VNS was applied under fasting conditions. This study indicated the suitability of applying thin-film intrafascicular electrodes for transversal insertion into small nerves (mean diameter of 400 μm), which, to the best of our knowledge, represents an advancement over the state of the art. It also establishes the feasibility of investigating neural pathways related to glucose homeostasis using invasive intraneural electrodes in the right cervical vagus nerve of rats
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Magnetoliposomes: envisioning new strategies for water decontamination
Full text linkIn this work, the inclusion of magnetic nanoparticles (MNPs) within phospholipid vesicles has been
investigated as novel strategy for improving stability and reactivity of these nanoparticles and extending their
potential use in the environmental field. Two phospholipids able to form liposomes characterized by different
rigidity and stiffness, were used as potential carriers of MNPs. The magneto-responsive liposomes were
investigated for their physicochemical and stability properties. In particular, the stability of the two systems
was indirectly investigated evaluating the ability of the hybrid constructs to retain a fluorescent marker in their
structure. Alterations in the permeability of the membranes were determined by the rate of the marker release
from the liposomes, under both mechanical and thermal stress conditions
- …
