33,544 research outputs found
Thomas Grisell letter to Thomas Rotch, 2nd mo 19th 1823
No full textThomas Grisell's letter reached the Rotch household several months before the unexpected death of Thomas Rotch in August, 1823. This is the last letter of the series and presumably the author learned of his friend's death before another letter was penned. 7.95" x 10" (20.2 by 25.5 cm
Immunohistochemical characterization of normal canine Merkel cells
No full textCutaneous Merkel cells (MCs) have been well documented in humans, but less in other mammals. In dogs, there are only a few references about immunohistochemical characterization of MCs. We present the immunohistochemical profile of MCs in the dog for the most reliable antibodies used in human medicine. Tissue samples from several locations were obtained from five adult dogs of both sexes and different age and breed, fixed in 10% buffered formalin, embedded in paraffin wax and cut in 3-mum tissue sections. The ABC method was used with different poly- and monoclonal antibodies. Positive immunoreaction was found in MCs of hair follicles, skin and mucosae of several locations in each dog studied for anticytokeratins 8, 18 and 20, anti-neurofilaments, anti-chromogranin A, anti-neuron-specific enolase, and anti-synaptophysin. Immunoreaction was always cytoplasmic with differences in intensity, pattern of intracytoplasmic distribution and reaction type. Other cytokeratins, anti-S100 protein, anti-vimentin and anti-glial fibrillary acid protein were absent in canine normal MCs.5549
Failed Censures: Ecclesiastical Regulation of Women’s Clothing in Late Medieval Italy
No full textChurchmen in the late thirteenth and early fourteenth centuries tried to regulate the costume of Italian women. These efforts failed, and regulation was largely left thereafter to civic authorities.The published version was published as Chapter 3 in Medieval Clothing and Textiles 5Izbicki, Thomas M. (2009), "Failed Censures: Ecclesiastical Regulation of Women’s Clothing in Late Medieval Italy" in Netherton, Robin and Owen-Crocker, Gale R., eds., Medieval Clothing and Textiles 5 (Boydell Press), 37-53ISBN: 9781843834519 (published book)Peer reviewe
Western medieval legal manuscripts in the collections of the University of Pennsylvania
No full textWestern legal manuscripts of the Middle Ages in North American collections are among the least known to scholars. The University of Pennsylvania has a rich collection of these texts, several of which were in the collection of the historian Henry Charles Lea. Included are works of civil law and canon law, as well as collections of papal letters and guides to pastoral care. The descriptions of most of these manuscripts in the catalog of Norman P. Zacour and Rudolf Hirsch are perfunctory, sometimes erring or omitting valuable information. Other manuscripts were added in recent years in the Lawrence J. Schoenberg Collection. Much of this material is being added to the Franklin online catalog of the University’s libraries, but researchers frequently do not search these digital resources. This article provides more complete guidance to the University’s medieval legal manuscripts than any of the existing catalogs offers, whether in print or online. It also provides updated bibliographic information in print or online. Every manuscript has been examined by the author in situ. Among the important works represented in the collection is the Panormia (a work of canon law often attributed to Ivo of Chartres). Authors present include the curialist Thomas of Capua, canonists Petrus de Braco, William of Pagula, Bernardus Raimundi, Adam of Aldersbach, Raymond of Peñafort, and civil lawyers Baldus de Ubaldis, and Bartolus de Saxoferrato. Three of these manuscripts were owned in the past by Sir Thomas Phillipps
Forbidden Colors in the Regulation of Clerical Dress from the Fourth Lateran Council (1215) to the Time of Nicholas of Cusa (d. 1464)
No full textMedieval canon law attempted to distinguish clergy from the laity by restricting their dress choices. The article focuses on prohibition of wearing red or green on the street. Both colors were identified with the nobility.The published version was published as Chapter 7 in Medieval Clothing and Textiles 1Izbicki, Thomas M. (2005), "Forbidden Colors in the Regulation of Clerical Dress from the Fourth Lateran Council (1215) to the Time of Nicholas of Cusa (d. 1464)" in Netherton, Robin and Owen-Crocker, Gale R., eds., Medieval Clothing and Textiles 1 (Boydell Press),105-114ISBN: 9781843831235 (published book
Thomas Crutchfield account book, 1848-1861
No full textA book containing business accounts, including details about travel expenses and the purchase and sale of lumber as well as other goods and services. The author also catalogs personal spending, the dates and pricing of properties offered for rent, and the purchase and leasing of enslaved people. Many entries are consistent with the business activities of Thomas Crutchfield Sr., who died in 1850. Someone continued to make entries in the book for activities dated up to 1861
Thomas Crutchfield account book, 1848-1861
No full textA book containing business accounts, including details about travel expenses and the purchase and sale of lumber as well as other goods and services. The author also catalogs personal spending, the dates and pricing of properties offered for rent, and the purchase and leasing of enslaved people. Many entries are consistent with the business activities of Thomas Crutchfield Sr., who died in 1850. Someone continued to make entries in the book for activities dated up to 1861
Thomas Hazard Jr letter to Thomas Rotch, New York 6 mo 10, 1821
No full textThe author acknowledges receipt of letters after the Rotch return to Kendal, Ohio in the late spring of 1821. Thomas Hazard mentions that his whaling ship, Dawn, has sailed to the Pacific Ocean with 23 hands on board and provisions for three years. He hopes to visit Kendal in the Fall, he also mentions that William Rotch Jr was recovering from a fever.
7.9" x 10" (20 by 25.5 cm
Molecular expression associated with vibrissa follicle development and differentiation
No full textThe hair follicle is a complex mini-organ formed as a result of epithelial mesenchymal interactions, provided by three different stem cell sources: epithelial, neural crest and mesenchymal. Hair follicle morphogenesis is directed by a distinct set of molecular signals which are unique to each stage of development. These interactions continue into the adult cycle, represented by periods of rapid growth (anagen), apoptosis driven regression (catagen), a period of relative quiescence (telogen) and shedding of the club hair (exogen). Many of the molecules involved have been elucidated such as Wnts, Bmps, Fgfs, TGF-ßs and Shh amongst others. However, the nature of their regulation and effect on gene expression is still unclear. Id proteins are emerging as powerful players in the transcriptional control of many fundamental biological processes, such as the cell cycle, proliferation and differentiation, apoptosis and lineage commitment. As a result, the expression patterns of Id2 and Ids were investigated by immunocytochemistry in developing and adult vibrissae. Wistar rats aged E14toP4 were used to cover all stages of vibrissae development (stages 0-6+) and 3-6 month old rats for the adult stages. This thesis reports that high Id2 expression was seen in specialised neuroendocrine cells (Merkel cells) of the hair follicle and basal epidermis, confirmed by co-expression of the Merkel cell marker, cytokeratin-20. This post-mitotic Id2 expression continued through postnatal ages and into the adult follicle. Staining with Id3 was characterised by cytoplasmic, basally polarised expression in the epithelia of stage 1-4 follicles. After this stage, expression switched to being nuclear with high levels in many different cell types including the dermal papilla, dermal sheath and outer root sheath, ш and Id3 expression was also investigated in retinole acid induced differentiation of E13.5 and E14 mystacial pads, studying the glandular morphogenesis of vibrissae and the effect on Id protein expression. Ш and Id3 immunoreactivity was cytoplasmic and polarised but no evidence of nuclear staining was seen.Id2 and ИЗ expression in developing vibrissae is reported here for the first time, describing the profiles of these proteins during hair follicle development and differentiation. These findings highlight an important cytoplasmic role for Id proteins in development and may have implications for reciprocal epithelial- mesenchymal interactions, pattern formation and stem cells in the hair follicle
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