1,721,028 research outputs found
A valid support to integrate the conventional scientific sources: Biomedical data banks accessible to students
No full textParodontite apicale refrattaria a trattamento endodontico associata a infezione extra-radicolare: descrizione di una caso clinico
No full textA valid support to supplement conventional scientific sources: Biomedical databases within students' reach
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Ritrattamento endodontico per via ortograda e risoluzione di ampie lesion apicali simil-cistiche: report di 2 casi
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Direct immunofluorescence to diagnose mucous membrane pemphigoid: A retrospective study
No full textOBJECTIVES Mucous membrane pemphigoid (MMP) is a group of rare acquired and autoimmune disorders charac-terized by the presence of autoanti-bodies against the epithelial-connective tissue junction that cause epithelial detachment and sub-epi-thelial blister formation. Direct im-munofluorescence (DIF) is the piv-otal exam for diagnosing MMP. The main objective of this retrospective study was to evaluate, in a group of patients affected by PMM, whether the multiple sample biopsy has a higher probability to obtain a positive DIF result compared to the single sample biopsy. MATERIALS AND METHODS Clinical records of patients affected by MMP and treated at the Unit of Oral Medicine and Oral Laser Surgery Unit of Parma University from 2000 and 2018 were retrieved. Inclusion criteria were:-presence of desquamative gingi-vitis and/or oral mucosa erosions, ulcers, blisters or scars with or without extra-oral involvement;-DIF exam demonstrating a linear deposition of IgG, IgA, or C3 along the epithelial basement membrane zone. The medical records of the patients included were reviewed and for each patient demographic and clinical data and those relating to the diagnostic investigations carried out were collected. For the samples subjected to the DIF test, the following were recorded: the location of the sample, whether the sample was single or multiple and the result of the analysis. RESULTS Nineteen patients were included, 10 females (53.6%) and 9 (47.4%) males which ages ranged from 39.9 to 84.2 years (mean = 66.1±13 years). A total of 30 spec-imens were submitted to DIF analysis and 21 resulted positive (70%). IgG, IgA and C3 deposits were observed in 71.4%, 28.6% and 76.1% of positive specimens, re-spectively. No correlation was found regarding test positivity and sampling site. In 12 interventions a single sample was collected and 9 resulted positive (75%). In 9 interventions 2 samples were collected and at least 1 specimen resulted positive in all the cases (100%). Three patients, who were initially DIF negative showed persistent le-sions, so they repeated the exam which then resulted positive. CONCLUSIONS Data from our patient cohort sug-gest that DIF is associated with a high percentage of false-negative results (30%), thus a negative DIF test does not exclude the MMP di-agnosis. Multiple and repeated sampling can enhance the chanc-es of diagnosis confirmation. CLINICAL SIGNIFICANCE Mucous membrane pemphigoid, although rare, is an important dis-order for the associated morbidity, and, exceptionally, mortality. An early correct diagnosis, based on clinical and laboratory data, is the first step for effective manage-ment of the affected patients. The direct immunofluorescence exam is mandatory for confirming the diagnosis but it shows some critical issues. Multiple and repeated biopsies are useful to reduce the number of missed diagnoses
Italian scientific production in dentistry: comparative bibliometric analysis of the last 3 decades
No full textOBJECTIVES In the last decades, Italian scientific production has grown in several areas of medical sciences, includ-ing dentistry. Understanding the trends and patterns of scientific production in dentistry can provide insights into the research interests and priorities of Italian researchers, as well as identify potential future research areas. Therefore, a large bibliometric analysis was conducted by analyz-ing all the articles published in the last 30 years in dental journals in-dexed in Scopus that had at least one author with Italian affiliation. We carried out a comparative anal-ysis by decade to study the trend of bibliometric parameters over time. MATERIALS AND METHODS In January 2023, all articles pub-lished from 1993 to 2022 in jour-nals indexed in the “Dentistry” category of Scopus with at least one author affiliated with any Ital-ian institution were searched. For each decade, the most active au-thors and affiliations, the most contributing journals, and the most cited articles were identified. Maps were created to represent the keyword co-occurrence net-work and the co-authorship net-work by country. Finally, the main topic, study type, and percentage of studies with foreign co-authors of the 1000 most cited articles in each decade were analyzed. RESULTS AND CONCLUSIONS Italian scientific production has in-creased progressively over time with an average growth rate of +10.2%; 1478 documents were published from 1993 to 2002 (first decade), 5968 documents from 2003 to 2012 (second decade) and 8859 documents from 2013 to 2022 (third decade). The year with the highest number of articles published was 2020 (n = 1038). Adriano Piattelli was the most pro-lific author in the first and second decades, while Giovanni Lodi was the first for the documents pub-lished during the third decade. The Università degli Studi di Milano was the most productive affiliation. The analysis of the authors’ key-words revealed a change in re-search interests over time. In the analysis of the 1000 most cited articles of each decade, a variation in the disciplines addressed and the type of study was ob-served. In general, the most fre-quent topics were “implantology”, “periodontology” and “oral pathol-ogy”, while the most frequent study type was “observational study”. The analysis of international col-laboration highlighted that the percentage of articles with at least one foreign author has increased over time, from 28% in the first decade, to 43% in the second one and 49% in the third one. CLINICAL SIGNIFICANCE Bibliometric analyses in academia have gained increasing impor-tance due to the need for objec-tive quantification of scientific out-put. This bibliometric study allows to highlight the contribution of Ita-ly to dental world research, to identify the most influential national authors or institutions, and the trends in interest in the differ-ent topics
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