1,721,007 research outputs found
Applying the GRADE framework for clinical guidelines in pediatrics: challenges and opportunities
No full textClinicians need recommendations for their daily practice. They also need to be able to appraise the trustworthiness of these recommendations. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework has been a major advance in this field. In this thesis, I discuss the specific challenges and potential solutions in applying GRADE to pediatric populations. In particular, I outline issues about (1) clarifying the target population in the presence of numerous age-groups; (2) the choice of patient-important outcomes for young children and their parents; (3) the limitations resulting from the evidence available in pediatrics, (4) the difficulty in finding trustworthy baseline risks for all relevant age-group; (5) the dynamics of values and preferences in pediatrics. Finally, since weak recommendations are preference-sensitive, I also discuss potential challenges of shared-decision making with pediatric patients who gradually express their autonomy and capacity of decision
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Etude de la sensibilité au glucose et du couplage métabolisme-sécrétion dans les cellules d'insulinome INS-1E durant deux années de culture continue
No full textProvenant d'insulinome de rat, les cellules INS-1 sont largement utilisées comme substituts de cellules beta. Elles sont hétérogènes et peu stables sur de longues périodes de cultures. Sur la base du contenu en insuline et de la réponse au glucose, nous avons isolé de manière clonale les cellules INS-1E. Nous décrivons la stabilité du phénotype de cellules beta différenciées, durant 116 passages (27-142), soit 2.2 ans de suivi continu. Les cellules INS-1E peuvent être utilisées avec fiabilité entre les passages 40 et 100, montrant un contenu moyen d'insuline de 2.3±0.11ug par million de cellules. Les cellules INS-1E présentent des réponses sécrétoires dans la gamme physiologique de concentrations en glucose ainsi que l'expression de la voie d'amplification. Nous avons mesuré plusieurs paramètres métaboliques. Les amas sphéroïdes ont aussi été testés quant à leurs réponses aux sécrétagogues. Ces données confirment la valeur de la lignée cellulaire INS-1E
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Le syndrome de tachycardie posturale chez les adolescent⸱e⸱s
No full textLe syndrome de tachycardie posturale (STPo) est un syndrome clinique polymorphe, peu connu et sous-diagnostiqué ; surtout chez les adolescent⸱e⸱s. Il résulte d'une dysautonomie. Le STPo est caractérisé par une tachycardie disproportionnée lors du passage de la position couchée à la position debout, associée à des plaintes somatiques multiples et récurrentes pendant plus de 6 mois. Son impact est majeur sur la qualité de vie des adolescent⸱e⸱s. Seul un test de Schellong est nécessaire pour poser le diagnostic. Le traitement est avant tout symptomatique. L'objectif principal est de reconditionner le patient, le plus rapidement possible. L'évolution vers la guérison est emmaillée de rechutes, mais le pronostic est le plus souvent favorable. Nous décrivons une série de cas chez 7 adolescent⸱e⸱s, âgé⸱e⸱s de 11 à 16 ans que nous suivons pour un STPo depuis 2015, à la consultation pour adolescent⸱e⸱s du service de pédiatrie générale, des Hôpitaux Universitaires de Genève (Suisse)
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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