28 research outputs found
[Photograph 2012.201.B0156.0728]
No full textPhotograph used for a newspaper owned by the Oklahoma Publishing Company. Caption: "Cynthia Defelice / Author
Men's Basketball, 1999-2000
No full textProgram contains messages from Dr. Franklyn Jenifer, UTD President, and Mary Walters, Director of Athletics. Athletic Depatment staff mentioned include Ray Farrell, Jerry Lokken, Preston Hill, Meredith Brandon, Chris DeFelice, Al Hanson, Rachelle Leonard, Jason Samuels, Jack Pell, Bob Luedtke and John Antonisse. The team roster consists of Chad Bagnell, Steven Beechum, Greg Foster, Joey Hadnot, Brent Harrolle, Tim Lazarus, Raymond Lee, Chad Martinez, Justin St. Julian, Corey Swan, Sandjiri Sy, Brian Thomas and Jason Walker. Shown on the front cover are Chris DeFelice (assistant coach), Jason Walker (#44), Greg Foster (#23), Tim Lazarus (#40), Brian Thomas (#33), Chad Bagnell (#42), Brent Harrolle (#32), SandJiri Sy (#41), Al Hanson (assistant coach), Ray Farrell (head coach), Greg Foster (#23), Justin St. Julian (#35), Corey Swan (#3), Chad Martinez (#5), Joey Hadnot (#24) and Steven Beechum (#21)
UTD Women's Soccer, 1999 Season
No full textProgram includes: 1) messages from Dr. Franklyn Jenifer (UTD President) and Mary F. Walters (Athletic Director). 2) A list of the Athletic Department Staff: Ray Farrrell, Jerry Lokken, Preston Hill, Meredith Brandon, Rachelle Leonard, Jack Peel, Scott Turner, Jeremy Morse, John Antonisse, Jennifer Damko, Tracy Ward and Chris DeFelice. 3) Women's team roster: Katy Turner, Cara Smedley, Christina Cox, Jennifer Dunn, Claire Burrows, Sarrah Carroll, Barbara Smith, Serena Fennell, Leia Pardue, Heather Ramsey, Ali Koen, Kristin Andrews, Aimee Reiners, Alison Mentzer, Katie Jacobson, Sarah Houle, Amber Peterson and Cindy Martinez
The producer as author. Graciela Carnevale's texts about her archive
No full textDe la multiplicidad de materiales que conforman el Archivo Graciela Carnevale, este trabajo aborda los textos donde la artista reflexiona sobre su archivo y las experiencias vitales que están en la base de su pulsión de colección. Para su análisis se postula, primero, una delimitación de las figuras de artistas relacionada con una noción expandida del archivo. Luego, se procede a exponer las potencialidades y problemáticas de considerar las reflexiones de las productoras sobre sus fondos personales. Finalmente, se propone un acercamiento a los textos a partir de sus tonos predominantes.From the multiplicity of materials that make up the Graciela Carnevale Archive, in this paper I address the texts in which the artist reflects on her archive and the life experiences that underlie the drive to collect these documents. For its analysis, I introduce, first, a delimitation of the figures of artists in relation to an expanded notion of the archive; secondly, I proceed to expose the potential and problems of considering the producers’ reflections on their personal archives; finally, I propose an approach to the texts based on their predominant tones.Facultad de Arte
Genomic correlates of recombination rate and its variability across eight recombination maps in the western honey bee (Apis mellifera L.)
No full textabstract: Background
Meiotic recombination has traditionally been explained based on the structural requirement to stabilize homologous chromosome pairs to ensure their proper meiotic segregation. Competing hypotheses seek to explain the emerging findings of significant heterogeneity in recombination rates within and between genomes, but intraspecific comparisons of genome-wide recombination patterns are rare. The honey bee (Apis mellifera) exhibits the highest rate of genomic recombination among multicellular animals with about five cross-over events per chromatid.
Results
Here, we present a comparative analysis of recombination rates across eight genetic linkage maps of the honey bee genome to investigate which genomic sequence features are correlated with recombination rate and with its variation across the eight data sets, ranging in average marker spacing ranging from 1 Mbp to 120 kbp. Overall, we found that GC content explained best the variation in local recombination rate along chromosomes at the analyzed 100 kbp scale. In contrast, variation among the different maps was correlated to the abundance of microsatellites and several specific tri- and tetra-nucleotides.
Conclusions
The combined evidence from eight medium-scale recombination maps of the honey bee genome suggests that recombination rate variation in this highly recombining genome might be due to the DNA configuration instead of distinct sequence motifs. However, more fine-scale analyses are needed. The empirical basis of eight differing genetic maps allowed for robust conclusions about the correlates of the local recombination rates and enabled the study of the relation between DNA features and variability in local recombination rates, which is particularly relevant in the honey bee genome with its exceptionally high recombination rate.Figures of the calculated local recombination rates along chromosomes 2 – 16 from eight different linkage maps, along with the average and variance of recombination rates, display the considerable heterogeneity of local recombination in the honey bee genome
Report from the Participation in the Current System Workgroup
No full textOSI2016 Workgroup Question: Do researchers and scientists participate in the current system of scholarly publishing because they like it, they need it, they don’t have a choice in the matter, or they don’t really care one way or another? What perceptions, considerations and incentives do academicians have for staying the course (like impact factors and tenure points), and what are their pressures and incentives for changing direction (like lowering publishing charges)?
The authors of scholarly works play a critical role in the scholarly communications system: authors are the original content creators, and in many or most cases are the original rightsholders and the ultimate decisionmakers when it comes to how, when, and where to publish their work. Although there are other significant participants in the current system (including publishers, librarians, information consumers, etc.), understanding and respecting the range of influences that shape author publication decisions are crucial to effecting change in the system. While recognizing the highly individual and diverse nature of author interests, we identified several priorities that stand out as driving decisions in the publication process. Career advancement concerns are primary, and the perceived currency of a publication mode or venue with promotion and tenure committees is a significant factor in decision making. A related, but distinct, factor is a publication venue’s perceived prestige among the authors’ peers. Both of these considerations have significant interplay with, and often serve as proxies for, scholarly authors’ overarching motivation to advance knowledge and make an impact in their fields. External factors may also direct author choice. Funder requirements and, in the case of works made for hire, employer requirements, can narrow the range of options available to authors. Survey evidence suggests that authors increasingly see open publication models as being consistent with, or in furtherance of, their goals as scholars.1 For instance, authors increasingly see open access (OA) publication as leading to wider circulation, greater visibility, and possibly more citations. Our task was to consider how we might accelerate these trends to facilitate openness in scholarship
Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO)
No full textAuthors: Jolene Ramsey, Brenley McIntosh, Daniel Renfro, Suzanne A. Aleksander¤a,Sandra LaBonte, Curtis Ross,, Adrienne E. Zweifel, Nathan Liles¤b,Shabnam Farrar, Jason J. Gill,, Ivan Erill,, Sarah Ades, Tanya Z. Berardini,Jennifer A. Bennett, Siobhan Brady, Robert Britton¤c, Seth Carbon, StevenM. Caruso, Dave Clements, Ritu Dalia¤d, Meredith Defelice, Erin L. Doyle,do Friedberg¤e, Susan M. R. Gurney¤f, Lee Hughes, Allison Johnson, JasonM. Kowalski¤g, Donghui Li, Ruth C. Lovering, Tamara L. Mans¤h,Fiona McCarthy¤i, Sean D. Moore, Rebecca Murphy, Timothy D. Paustian,Sarah Perdue¤j, Celeste N. Peterson, Birgit M. Pru¨ß, Margaret S. Saha, RobertR. Sheehy, John T. Tansey, Louise Temple, Alexander William Thorman,Saul Trevino, Amy Cheng Vollmer, Virginia Walbo, Joanne Willey,Deborah A. Siegele*, James C. Hu,Experimental data about gene functions curated from the primary literature have enormous value for research scientists in understanding biology. Using the Gene Ontology (GO), manual curation by experts has provided an important resource for studying gene function, especially within model organisms. Unprecedented expansion of the scientific literature and validation of the predicted proteins have increased both data value and the challenges of keeping pace. Capturing literature-based functional annotations is limited by the ability of biocurators to handle the massive and rapidly growing scientific literature. Within the community-oriented wiki framework for GO annotation called the Gene Ontology Normal Usage Tracking System (GONUTS), we describe an approach to expand biocuration through crowdsourcing with undergraduates. This multiplies the number of high-quality annotations in international databases, enriches our coverage of the literature on normal gene function, and pushes the field in new directions. From an intercollegiate competition judged by experienced biocurators, Community Assessment of Community Annotation with Ontologies (CACAO), we have contributed nearly 5,000 literature-based annotations. Many of those annotations are to organisms not currently well-represented within GO. Over a 10-year history, our community contributors have spurred changes to the ontology not traditionally covered by professional biocurators. The CACAO principle of relying on community members to participate in and shape the future of biocuration in GO is a powerful and scalable model used to promote the scientific enterprise. It also provides undergraduate students with a unique and enriching introduction to critical reading of primary literature and acquisition of marketable skills.Support for teaching space was provided by the Department of Biochemistry & Biophysics at Texas A&M University. Annotators from across the globe have participated in CACAO competitions, including teams from University College London, University of North Texas, Miami University (Ohio), Penn State University, Michigan State University, North Dakota State University, Hofstra University, Swarthmore College, Houston Baptist University, Mississippi State University, University of Wisconsin-Madison, University of Wisconsin-Parkside, University of Central Florida, Otterbein University, Centenary College of Louisiana, Harvard University, John Brown University, Minnesota State-Morehead, Suffolk University, University of California-Davis, Stanford University, Doane University, Drexel University, James Madison University, Oakland University, Radford University, University of Cincinnati, University of Maryland, Baltimore County, and Virginia Commonwealth University. The contributions of hundreds of student users are proudly acknowledged. We are thankful to colleagues in the Gene Ontology Consortium for their active support and collaboration on this community annotation project. The authors extend an apology to any contributors not named here; however, their participation was foundational to the work and is deeply appreciated as well. This manuscript is dedicated to our beloved coauthor, the late Dr. James “Jim” C. Hu, a committed educator, microbial advocate, and invaluable scientific community member.https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.100946
Author correction: Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues
No full textIn the original version of this Article, the concentration of boric acid buffer for the SDS clearing solution was given incorrectly as '1 M sodium borate' and should have read '0.2 M boric acid'. Also, the composition of PBST incorrectly read '1% Triton X-100 (vol/vol) and 0.1% sodium azide (wt/vol)' and should have read '0.1% Triton X-100 (vol/vol) and 0.01% sodium azide (wt/vol)'. Further, the pH of the OPTIClear solution was not stated, and should have read 'with a pH between 7 to 8 adjusted with hydrochloric acid'. These errors have been corrected in both the PDF and HTML versions of the Article
AN N-TERMINAL THREONINE MUTATION PRODUCES AN EFFLUX FAVORABLE, SODIUM-PRIMED CONFORMATION OF THE HUMAN DOPAMINE TRANSPORTER MOL #91926 2 Running title: A Sodium-primed and Efflux-favorable Conformation of DAT Corresponding Author
No full textInteractions of dietary whole-grain intake with fasting glucose-and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies
No full textObjective: Whole grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. Research Design & Methods: Via meta-analysis of data from 14 cohorts comprising approximately 48,000 participants of European descent, we studied interactions of whole grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a p-value <0.0028 (0.05/18 tests) as statistically significant. Results: Greater whole grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (? [95% CI] per 1-serving greater whole grain intake: ?0.009 mmol/L glucose [?0.013, ?0.005], p <0.0001 and ?0.011 pmol/L (ln) insulin [?0.015, ?0.007], p =0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole grain intake was rs780094 (GCKR) for fasting insulin (p = 0.006), where greater whole grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele. Conclusions: Our results support the favorable association of whole grain intake with fasting glucose and insulin and suggest potential interaction between variation in GCKR and whole grain intake in influencing fasting insulin concentrations. <br/
