5,626 research outputs found
Syntéza inhibitorů proteinových kináz využitelných v terapii nádorových onemocnění
No full textCharles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry in collaboration with Biomedical Research Center UH HK Author: Sara Merdita Supervisor: Assoc. Prof. PharmD. Jaroslav Roh, PhD. Advisors: PharmD. Lukáš Górecki, PhD.; Assoc. Prof. PharmD. Jan Korábečný, PhD. Title of diploma thesis: Synthesis of protein-kinase inhibitors as a potential treatment for cancer Cancer is one of the leading causes of fatalities worldwide, which is attracting attention of many researchers with desire to develop treatments that selectively target cancerous cells while simultaneously sparing healthy cells. The main overall strategy is to exploit features specific to cancer - the cancer hallmarks. Those are represented, for instance, by genomic instability and aberrant DNA damage response (DDR) pathways. The DDR consists of cascades of kinases and other proteins and messengers, where we highlighted the synthetic lethal interaction between the kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related). The two are major driving forces in the DDR, where in cancer ATM tends to be mutated and therefore dysfunctional, making the cells' viability reliant on ATR. Thus, ATR inhibition makes a particularly attractive strategy for abrogating cancer survival without...Univerzita Karlova Farmaceutická fakulta v Hradci Králové Katedra organické a bioorganické chemie ve spolupráci s Centrem biomedicinského výzkumu FN HK Autorka: Sara Merdita Školitel: doc. PharmDr. Jaroslav Roh, PhD. Konzultanti: PharmDr. Lukáš Górecki, PhD.; doc. PharmDr. Jan Korábečný, PhD. Název diplomové práce: Syntéza inhibitorů proteinových kináz využitelných v terapii nádorových onemocnění Zhoubné nádory jsou jednou z hlavních příčin úmrtí po celém světě, což motivuje výzkumníky vyvinout léčbu, která selektivně cílí na nádorové buňky a zároveň ušetří zdravé buňky. Hlavní celkovou strategií je využít rysy specifické pro nádory. Ty jsou reprezentovány například nestabilitou genomové integrity a narušenou schopností opravy poškozené DNA (anglicky DDR). DDR se skládá z kaskád kináz a dalších proteinů a poslů, z nichž jsme se soustředili na syntetickou letální interakci mezi kinázami ATM (ataxia-telangiectasia mutated) a ATR (ATM and Rad3 related). Tyto dvě kinázy jsou předními hnacími silami v DDR, kde u nádorů má ATM tendenci být mutována, tedy dysfunkční, a tudíž životaschopnost buněk zbývá na ATR. Inhibice ATR je z toho důvodu zvláště atraktivní strategií pro eliminaci nádorových buněk, aniž by přitom byly zasaženy buňky zdravé. Čtyři inhibitory ATR již vstoupily do klinických studií jako...Department of Organic And Bioorganic ChemistryKatedra organické a bioorganické chemieFaculty of Pharmacy in Hradec KrálovéFarmaceutická fakulta v Hradci Králov
Synthesis of protein-kinase inhibitors as a potential treatment of cancer
No full textCharles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry in collaboration with Biomedical Research Center UH HK Author: Sara Merdita Supervisor: Assoc. Prof. PharmD. Jaroslav Roh, PhD. Advisors: PharmD. Lukáš Górecki, PhD.; Assoc. Prof. PharmD. Jan Korábečný, PhD. Title of diploma thesis: Synthesis of protein-kinase inhibitors as a potential treatment for cancer Cancer is one of the leading causes of fatalities worldwide, which is attracting attention of many researchers with desire to develop treatments that selectively target cancerous cells while simultaneously sparing healthy cells. The main overall strategy is to exploit features specific to cancer - the cancer hallmarks. Those are represented, for instance, by genomic instability and aberrant DNA damage response (DDR) pathways. The DDR consists of cascades of kinases and other proteins and messengers, where we highlighted the synthetic lethal interaction between the kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related). The two are major driving forces in the DDR, where in cancer ATM tends to be mutated and therefore dysfunctional, making the cells' viability reliant on ATR. Thus, ATR inhibition makes a particularly attractive strategy for abrogating cancer survival without..
A Floating Question Mark: An Interview with Sara Hawys Roberts, Author of Withdrawn Traces: Searching For The Truth About Richey Manic
No full textAn interview with Sara Hawys Roberts, co-author of 'Withdrawn Traces: Searching For The Truth About Richey Manic' about the researching and writing of this much-anticipated book about the missing Manic Street Preacher.</p
A Floating Question Mark: An Interview with Sara Hawys Roberts, Author of Withdrawn Traces: Searching For The Truth About Richey Manic
No full textAn interview with Sara Hawys Roberts, co-author of 'Withdrawn Traces: Searching For The Truth About Richey Manic' about the researching and writing of this much-anticipated book about the missing Manic Street Preacher.</p
Sara Gossett Crigler Collection - Accession 614
No full textThe Sara Gossett Crigler Collection consists of a microfiche copy of her book titled, Education For Girls And Women In Upper South Carolina Prior to 1890 with Related Miscellaneous Articles: A Compilation by Mrs. Henry Towles Crigler (Sara Gossett Crigler), self-published in Greenville, SC on April 15, 1956. This book also includes many anecdotes and reminiscences of Sara’ family including a section devoted to the slaves owned and later freed after the Civil War by her family. The book is dedicated by the author, Sara Gossett Crigler (1886-1966), to her mother Sallie Brown Gossett (1859-1942) and her aunt Mary Brown Mahon (1861-1948) who were both graduates of Williamston Female College in 1877 and 1879 respectively. The 170 page volume would be useful to anyone doing research on the education of women in South Carolina during the 19th century. The original copy is housed at the South Carolina Historical Society as SCHS 509 and was dedicated and signed by the author, “For the Charleston Library Society” on July 10, 1964.
*Please see attached Table of Contentshttps://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1527/thumbnail.jp
Materia-autore = Author-Matter
No full textThe etymology of the word author refers to an act of creation, an act of augmentation, from the Latin verb augere. Author instantiates creation, the expansion of the pre-existing. In 1967 Roland Barthes declared the death of the author in his famous essay to state once more that the crisis is that of the author as a single subjectivity and as a term that condenses prestige, undermined by the de-subjectivation strategies of automatism, fortuity and fragmentation of the historical avant-gardes, as well as by the machinic act and by the reproducibility of the second avant-gardes.
Fifty years after Barthes’ paradigmatic formula, this lack of authorship appears to be a successful brand. The ten- sions between the anomie of matter, the law that establishes authorship and the economy that makes the work pos- sible, invoke discordant perspectives. Artists make the self-destruction of their work the real work, and appeal is made for the demolition of architectures, whether by a recognised author or not, in order to re-design, or better still, re-claim the territory. Artificial intelligence consolidates its logics and its design by progressively shedding human ingenuity. The space of criticism becomes, finally, increasingly ephemeral. However, there is an acceptation of criti- cism that is, rather than an individual ‘signature’, an exploration and explanation of how design makes theory.
The binomial author-matter seeks to mark these tensions and contradictions: the featured term author is main- tained to underline the persistence of that prestigious subjectivity, at the very moment when the rhetoric of “mat- ter as an author” promises other forms of authorship
Sara Winthrop Smith letter to Frances Casement, August 14, 1887
No full textLetter written to Frances Casement from Sara Winthrop Smith of Cincinnati, Ohio, August 14, 1887. Winthrop expresses the challenges of generating support for the suffrage movement among the conservative residents of her city, and encourages the creation of clear materials that make the argument for women's suffrage to be more widely distributed.
This item comes from the Frances Jennings Casement Papers, a manuscript collection comprised of letters and association records related to the founding and leadership of the Ohio Woman Suffrage Association. Casement (1840-1928) was born in Painesville, Ohio, and graduated from Painesville Academy and Willoughby Female Seminary. Her father, Charles Casement, supported abolition and women's suffrage and encouraged Frances to be active in social causes. Frances Casement established the Painesville Equal Rights Association in 1883, and shortly after became involved in the Ohio Woman Suffrage Association, serving as its president from 1885 to 1888
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