1,274 research outputs found
MetNet: A two-level approach to reconstructing and comparing metabolic networks.
No full textMetabolic pathway comparison and interaction between different species can detect important information for drug engineering and medical science. In the literature, proposals for reconstructing and comparing metabolic networks present two main problems: network reconstruction requires usually human intervention to integrate information from different sources and, in metabolic comparison, the size of the networks leads to a challenging computational problem. We propose to automatically reconstruct a metabolic network on the basis of KEGG database information. Our proposal relies on a two-level representation of the huge metabolic network: the first level is graph-based and depicts pathways as nodes and relations between pathways as edges; the second level represents each metabolic pathway in terms of its reactions content. The two-level representation complies with the KEGG database, which decomposes the metabolism of all the different organisms into "reference" pathways in a standardised way. On the basis of this two-level representation, we introduce some similarity measures for both levels. They allow for both a local comparison, pathway by pathway, and a global comparison of the entire metabolism. We developed a tool, MetNet, that implements the proposed methodology. MetNet makes it possible to automatically reconstruct the metabolic network of two organisms selected in KEGG and to compare their two networks both quantitatively and visually. We validate our methodology by presenting some experiments performed with MetNet
Luis Prieto semiootiline teooria
No full textVäitekirja elektrooniline versioon ei sisalda publikatsiooneLuis Jorge Prieto (1926–1996) oli Argentina semiootik ja keeleteadlane, viimane Ferdinand de Saussure'i üldkeeleteaduse õppetooli hoidja Genfi Ülikoolis Šveitsis. Väljaspool prantsuse ja itaalia semiootikat (tema mõju on tunda näiteks Umberto Eco, Tullio de Mauro ja Paolo Fabbri töödes) on Prieto seni jäänud suhteliselt vähetuntud autoriks. Käesolev doktoritöö, esimene, mis on temast inglise keeles kirjutatud, sisaldab Prieto intellektuaalse biograafia ning tema teoste teoreetilise ja ajaloolise analüüsi, põhinedes bibliograafilistel allikatel ning Córdoba, Buenos Airese ja Genfi ülikoolides tehtud arhiiviuuringutel. Töö vaatleb ka Prieto teooria heuristilist rolli kaasaegse semiootika valguses. Sellega seoses analüüsitakse Prieto mõistetesüsteemi, mis sisaldab mitmeid algupäraseid mõisteid – nt sobivus, klassifikatsioonisüsteem, semiootiline struktuur – seoses teiste semiootikute mõistestikega, seejuures nii klassikalises semiootikas (Ferdinand de Saussure, Jakob von Uexküll, Louis Hjelmslev, Roman Jakobson) kui ka tänapäevaste autorite puhul (John Deely, Terrence Deacon). See võimaldab lähendada Prieto kontseptsioone praegusaegse üldsemiootika teooriaga. Sellise üldsemiootika puhul käsitletakse semiootikat kui distsipliini, mis uurib tähenduse arbitraarsust selle kõigis vormides ning tähenduse ja märkide arbitraarsusest tulenevaid tagajärgi. Lisaks on väitekirja osaks kommenteeritud tõlked Prieto kahest väga olulisest artiklist, mis pole varem inglise keeles ilmunud.Luis Jorge Prieto (1926–1996) was an Argentinian semiotician and linguist, the last holder of Ferdinand de Saussure’s chair in general linguistics in the University of Geneva, Switzerland. Yet, outside Italian semiotics, where his influence is felt in the works of scholars like Umberto Eco, Tullio de Mauro, and Paolo Fabbri, and the French-speaking milieu of the discipline, Prieto remains to be a little-known author. This dissertation, the first one written about him in English, provides Prieto's intellectual biography and a theoretical and historical analysis of his works, based on bibliographical sources and on archival research carried out at the Universities of Córdoba, Buenos Aires and Geneva. It includes, as well, a study on the heuristic capacities of Prieto’s theory in the light of contemporary semiotics. In this regard, Prieto's conceptual system, which includes several original concepts –pertinence, classification system, semiotic structure, among others –, is analyzed in relation to other scholars of semiotics, both classical, like Ferdinand de Saussure, Jakob von Uexküll, Louis Hjelmslev, Roman Jakobson, and contemporaries, like John Deely and Terrence Deacon. This allows to approximate Prieto’s concepts as the building blocks of a general semiotic theory. The formulation of such a general semiotics is achieved by conceiving semiotics as a discipline which studies the arbitrariness of meaning in all its forms, and the consequences that follow from meaning and signs being arbitrary. In addition, the dissertation includes two annotated translations of two seminal articles of Prieto that have not appeared in English before.https://www.ester.ee/record=b550784
La cultura oratoria y la experiencia forense de Guillermo Prieto
No full text"El ejercicio de la palabra hablada" of Guillermo Prieto is a vein not yet explored by criticism, although the recovery of this part of his cultural inheritance is of great importance, as muchfor literary history as for biographical knowledge of the author. The author exhaustively studies and documents one of the most representative cases of the discursive skill of Prieto before the courts: the defense of Augustín Rosales."El ejercicio de la palabra hablada" de Guillermo Prieto es una veta inexplorada por la crítica, a pesar de que la recuperación de esta parte de su legado cultural es de suma imponancia, tanto para la historia literaria como para el conocimiento biográfico del autor. La autora estudia y documenta de manera exhaustiva uno de los casos más representativos de la destreza discursiva de Prieto ante los tribunales: la defensa de Agustín Rosales
"Secretum" de Antonio Prieto. La novela de una canción
No full textAntonio Prieto´s novel Secretum is seen in these lines as a poetic biography where the author rewrites Petrarch´s Canzoniere in a dialogue among many voices and within a science fiction novel pattern. The same way that Petrarch in his Canzoniere talks to Saint Augustine as he himself did with God in his Confessions. It is indeed the same dialogue that every reader holds with the books he reads. This novel is therefore analyzed as the mythical fusion between Antonio Prieto and Petrarch in an attempt to rescue and save the past (as the author himself states through one of his characters) and in so doing Antonio Prieto becomes a modern interlocutor laden with memory.La novela de Antonio Prieto, Secretum, se observa en estas líneas como una biografía poética en la que el autor reescribe el Cancionero de Petrarca en un diálogo cantado a varias voces y en un molde de novela de ciencia ficción. Del mismo modo que Petrarca en su Cancionero dialogó con San Agustín y éste último, en sus Confesiones, lo hizo con Dios. Es el diálogo que, en definitiva, mantiene cada lector con los libros que lee. Se analiza, pues, esta novela como la fusión mítica de Antonio Prieto con Petrarca en un intento de recuperar y salvar el pasado, (así lo dice el propio autor a través de uno de sus personajes), que convierte a Antonio Prieto en un moderno interlocutor cargado de memoria
PRIETO, Manuel G.
No full textEssay by Manuel G. Prieto, Mexican Consul in New York. This paper is entitled "El problema eclesiástico en México" [The ecclesiastic problem in Mexico], in which the author discusses the huge challenge for Mexico to separate the Church from the State. He supports his argument by stressing the economic power in assets that the Catholic sectors hold and their participation in the country’s education and politics. / Obra de Manuel G. Prieto, Cónsul General de México en Nueva York intitulada "El problema eclesiástico en México", en la que sustenta la tesis del enorme problema que ha representado para México llevar a cabo la separación entre la Iglesia y el Estado, apoya su argumento refiriéndose a los bienes económicos que detentan los sectores católicos y su participación en la educación y en la política del país
The road not yet taken: how law student information literacy standards address identified issues in legal research education and training
No full textLegal research education has been slow to adopt information literacy as a framework, despite the demonstrated utility of this framework when applied to library instruction and assessment. This article defines law student information literacy (LSIL), analyzes how LSIL standards address existing and identified deficits in the current state of legal research education, and offers a copy of the draft LSIL standards. The recently approved AALL Law Student Research Competencies and Information Literacy Principles are appended to the article.Peer reviewe
En busca del tiempo homérico con la mirada y la palabra de Antonio Prieto (lectura de "El ciego de Quíos")
No full textIn The blind person of Quíos, the novelist Antonio Prieto invents Homero's life feeding it with figures and facts from the Ilíada and, especially, from the Odyssey. The story is enriched by the historical knowledge about these great poems, and is framed in a rich mythological context. Beyond this, the novel reaches a transcendent meaning. We discover as narrative engine the Homeric effort to overcome the human fleetingness by means of the writing, thus creating a timeless link with the own longing of our author; this way, the novel offers us a maximum example of what Antonio Prieto termed as mythical fusion.En El ciego de Quíos, el novelista Antonio Prieto inventa la vida de Homero alimentándola con figuras y hechos procedentes de la Ilíada y, sobre todo, de la Odisea. El relato se enriquece con el conocimiento histórico en torno a los dos grandes poemas, y lo enmarca un amplio despliegue mitológico. Más allá, la novela alcanza un significado trascendente. Descubrimos como motor narrativo el esfuerzo homérico por vencer la fugacidad humana mediante la escritura, lo que crea un vínculo atemporal con el propio anhelo de nuestro autor; así, la novela nos ofrece un ejemplo máximo del fenómeno bautizado como fusión mítica por Antonio Prieto
Los ensayos político-culturales de Emilia Prieto Tugores (1932-1974)
No full textThe author of this article makes an approach to the political-cultural discussion held by Emilia Prieto Tugores in her essays, published during the decades from 1930 to 1970 in national journals and newspapers. The aim is to recognize both the critical point of view and the revolutionary political activity in her writings, begun before Costa Rican women get the right to vote. This article is part of a research in process about Prieto’s essay works.En este artículo se realiza un acercamiento al debate político-cultural sostenido por Emilia Prieto Tugores en ensayos publicados durante los decenios del treinta al setenta del siglo XX, en revistas y periódicos de circulación nacional. La finalidad es reconocer la visión crítica y el quehacer político contestatario que se plasman a través de su escritura, iniciada antes de que las mujeres costarricenses se ganaran el derecho al sufragio. El trabajo forma parte de una investigación en proceso, sobre la obra ensayística de Prieto
Los ensayos político-culturales de Emilia Prieto Tugores (1932-1974)
No full textThe author of this article makes an approach to the political-cultural discussion held by Emilia Prieto Tugores in her essays, published during the decades from 1930 to 1970 in national journals and newspapers. The aim is to recognize both the critical point of view and the revolutionary political activity in her writings, begun before Costa Rican women get the right to vote. This article is part of a research in process about Prieto’s essay works.En este artículo se realiza un acercamiento al debate político-cultural sostenido por Emilia Prieto Tugores en ensayos publicados durante los decenios del treinta al setenta del siglo XX, en revistas y periódicos de circulación nacional. La finalidad es reconocer la visión crítica y el quehacer político contestatario que se plasman a través de su escritura, iniciada antes de que las mujeres costarricenses se ganaran el derecho al sufragio. El trabajo forma parte de una investigación en proceso, sobre la obra ensayística de Prieto
L’entamu inéditu del poema «La ‘sfoyaza» de Francisco González Prieto
No full textEl hallazgo de un manuscrito autógrafo de Francisco González Prieto en el archivo de Enrique García Rendueles permite editar un texto conocido del autor, publicado en un periódico cubano en 1922, corrigiendo erratas y añadiendo cuarenta versos iniciales que faltaban.The discovery of an autograph manuscript by Francisco González Prieto in the archive of Enrique García Rendueles allows us to edit a known text of the author, published in a Cuban newspaper in 1922, correcting misprints and adding forty missing initial versesEl descubrimientu d’un manuscritu autógrafu de Francisco González Prieto nel archivu d’Enrique García Rendueles permítenos editar un testu yá conocíu del autor, asoleyáu nun periódicu cubanu en 1922, corrixendo errates y añadiendo los cuarenta versos iniciales que faltaben.peerReviewe
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