1,721,008 research outputs found
6-year outcomes of the United Kingdom Medisoft® audit study following treatment with the ILUVIEN® (fluocinolone acetonide) implant in patients with diabetic macular edema.
No full textPurpose: The Medisoft study was designed as a retrospective audit of eyes treated with the fluocinolone acetonide (FAc) implant and aimed to assess the long-term effectiveness and safety of FAc implant in patients with diabetic macular edema (DME) that persists or recurs despite treatment. Outcomes from this study have previously been reported in patients monitored for ≥3 years. We now report outcomes obtained in the last 3-years since the initial outcomes were reported. Methods. The Medisoft audit tool was used to extract pseudo-anonymised electronic medical records (EMR), identifying only patients with DME that had been treated with the FAc implant across 14 UK clinical sites between 2014 and 2022. Clinical effectiveness and safety were measured.Results. Data were available from 302 eyes (256 patients) with ≥3 years of follow-up. The mean follow-up period was 64.2±18.4 months [mean±SD]). Best-recorded visual acuity (BRVA) was 56.8±15.6 letters, 59.2±17.1 letters and 60.54±15.6 letters at baseline, 3 and 6 years respectively. At years 3 and 6, stable/improved BRVA was observed in 75.6% and 74.6% respectively. The proportion of eyes with 6/12 (20/40) or better BRVA rose from 22.5% at baseline to 35.2% and 39.7%, respectively. In terms of safety, mean IOP was 16.3±4.1 mmHg at baseline and remained below a mean value of 21 mmHg at years 3 and 6. Around one third (36.1%) of eyes required topical IOP-lowering drops to control elevations in pressure (versus 21.5% of eyes pre-FAc implant) and IOP was >30 mmHg at a single time point post-FAc implant in 25.5% of eyes (versus 10.6 pre-FAc implant).Conclusions. Over a 6-year follow-up period, UK EMR data obtained in real-world practice revealed that three-out-of-four patients with DME and treated with a FAc implant benefited from stable/improved BRVA and that one-in-three had visual acuity 6/12 or better. This data was obtained since the first eye was treated in the UK and is an ongoing study that will continue to monitor the outcomes and the management of DME patients in clinical practice.<br/
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Judgments of behavioral frequencies: An information processing perspective
No full textU of I OnlyIn marketing and consumer research, respondents are often asked questions about the frequency with which they engage in various behaviors (e.g., bank loans taken, purchases of durable goods, consumption of snack foods). The information processing demands that such questions placed on the respondent can be tremendous. For some behaviors, it may be easy to recall all specific instances of the target behavior and provide an exact count. For relatively frequent behaviors, however, this recall-and-count method may be difficult or impossible; instead consumers are likely to use heuristics to arrive at a behavioral frequency estimate.This research examines the process by which frequency judgments are generated for frequent behavior with the goals of (a) contributing to our knowledge of the cognitive processing of autobiographical information (organization and structure in memory, retrieval strategies), and (b) understanding how different questioning strategies may improve the accuracy of such behavioral frequency judgments.It is hypothesized that the regularity and the similarity of the target behavior determine the way the requisite information is stored in memory and therefore the process by which the judgment is generated. This, in turn, determines the effectiveness of alternative cuing strategies. These hypotheses are tested by obtaining judgments of the frequency of behaviors varying on regularity and similarity. The dependent measures are: (a) verbal protocols, concurrent and retrospective, (b) response time to generate a frequency judgment, and (c) the discrepancy between reported frequency and objective frequency (diary data).Data indicate that there is support for the model of autobiographical memory for frequent events tested in this research. However, the cuing strategies tested seem to interfere with the natural process of frequency judgment formulation in a way that they do not contribute to improving the accuracy of these reports.Theoretical implications of the results for autobiographical information processing and questionnaire and survey design are discussed, together with practical implications and proposed extensions for future research.Made available in DSpace on 2011-05-07T12:14:38Z (GMT). No. of bitstreams: 2
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Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
The Effect of Systemic Levels of TNF-alpha and Complement Pathway Activity on Outcomes of VEGF Inhibition in Neovascular AMD
No full textBackground/Objectives: Systemic levels of pro-inflammatory cytokines and activated complement components affect the risk and/or progression of neovascular age-related macular degeneration (AMD). This study investigated the effect of serum pro-inflammatory cytokine levels and complement pathway activity on the clinical response to vascular endothelial growth factor (VEGF) inhibition in neovascular AMD. Methods: Sixty-five patients with a new diagnosis of neovascular AMD were observed over a six-month period in a single-centre, longitudinal cohort study. At each visit, the visual acuity score (VAS), central macular thickness (CMT), serum levels of CRP, pro-inflammatory cytokines (TNF-α, IL-1β, IL-2, IL-6 and IL-8), and complement pathway activity were measured. Participant DNA samples were sequenced for six complement pathway single nucleotide polymorphisms (SNPs) associated with AMD. Results: A statistically significant difference in VAS was observed for serum levels of TNF-α only: there was a gain in VAS (from baseline) of 1.37 for participants below the 1st quartile of mean concentration compared to a reduction of 2.71 for those above the 3rd quartile. Statistical significance was maintained after Bonferroni correction (P value set at <0.006). No significant differences in CMT were observed. In addition, statistically significant differences, maintained after Bonferroni correction, were observed in serum complement activity for participants with the following SNPs: CFH region (rs1061170), SERPING1 (rs2511989) and CFB (rs641153). Serum complement pathway components did not significantly affect VAS. Conclusions: Lower serum TNF-α levels were associated with an increase in visual acuity after anti-VEGF therapy. This suggests that targeting pro-inflammatory cytokines may augment treatment for neovascular AMD.</p
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